Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2OVDT)

Drug Name

TECFIDERA Drug Info

Synonyms

DIMETHYL FUMARATE

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Approved	[1]

Cross-matching ID

PubChem CID: 637568
ChEBI ID: CHEMBL2107333
CAS Number: CAS 624-49-7
TTD Drug ID: DM2OVDT
ACDINA Drug ID: D00202

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Selenium	DM25CGV	N. A.	N. A.	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[16]
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Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[22]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[23]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
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Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[31]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[32]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[30]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[37]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[42]
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Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[46]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NFE2-related factor 2 pathway (Nrf2 pathway)	TTK3Q4W	NOUNIPROTAC	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[3]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Gene/Protein Processing	[4]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Gene/Protein Processing	[4]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Gene/Protein Processing	[5]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)	OTRAFFX2	GPX4_HUMAN	Biochemical Pathways	[6]

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References

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