Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3INX7)

Drug Name

EPZ015666 Drug Info

Synonyms

EPZ-015666; EPZ 015666

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 90241673
TTD Drug ID: DM3INX7

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Protein arginine methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK3326595	DMJRD7A	Breast cancer	2C60-2C65	Phase 2	[5]
AMG 193	DMU9K8N	Aggressive cancer	2A00-2F9Z	Phase 2	[6]
PRT811	DMW3MCX	Glioma	2A00.0	Phase 1	[7]
PRT543	DMHNZ3U	Hematologic tumour	2B33.Y	Phase 1	[8]
JNJ-64619178	DMDBW2N	Myelodysplastic syndrome	2A37	Phase 1	[9]
PF-06939999	DM7BOFR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
DS-437	DME3WBQ	Discovery agent	N.A.	Investigative	[11]
cmp5	DMBT2ZW	Discovery agent	N.A.	Investigative	[12]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[19]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
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Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[25]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[31]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[35]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[36]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[39]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[50]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[52]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[57]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[19]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[60]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[19]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[66]
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Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[67]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[68]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[79]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[83]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[88]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[92]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[93]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein arginine methyltransferase 5 (PRMT5)	TTR1D7X	ANM5_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[3]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Gene/Protein Processing	[3]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Protein Interaction/Cellular Processes	[3]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Protein Interaction/Cellular Processes	[3]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[4]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[3]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Post-Translational Modifications	[3]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Post-Translational Modifications	[3]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Gene/Protein Processing	[3]

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References

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