Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM48K0X)

Drug Name
Carfilzomib Drug Info
Synonyms
Carfilzomib; 868540-17-4; Kyprolis; Carfilzomib (PR-171); PR-171; UNII-72X6E3J5AR; 72X6E3J5AR; CHEMBL451887; CHEBI:65347; NCGC00249613-01; DSSTox_RID_82886; DSSTox_CID_28616; DSSTox_GSID_48690; (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide; N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Approved [1]
Plasma cell myeloma 2A83.1 Approved [2]
Small-cell lung cancer 2C25.Y Phase 1/2 [3]
Cross-matching ID
PubChem CID
11556711
ChEBI ID
CHEBI:65347
CAS Number
CAS 868540-17-4
TTD Drug ID
DM48K0X
VARIDT Drug ID
DR01324
ACDINA Drug ID
D00915

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Proteasome (PS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bortezomib DMNO38U Leukemia Approved [11]
MLN9708 DMCMETN Amyloidosis 5D00 Approved [12]
Marizomib DME9QGW Glioblastoma of brain 2A00.00 Phase 3 [13]
Oprozomib DM16RIC Hodgkin lymphoma 2B30 Phase 2 [14]
Delanzomib DMX4DQH Multiple myeloma 2A83 Phase 2 [15]
GSK3494245 DMSMQGL Visceral leishmaniasis 1F54.0 Phase 1 [16]
PS-519 DMI0WHC Ischemia-reperfusion injury DB98.B Terminated [17]
MG-101 DM3RUT8 Discovery agent N.A. Investigative [18]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [31]
Prednisone DM2HG4X Acute asthma CA23 Approved [32]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [39]
Paclitaxel DMLB81S Breast carcinoma Approved [40]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
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Drug(s) Affected By Cytochrome c oxidase subunit 8A, mitochondrial (COX8A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Bortezomib DMNO38U Leukemia Approved [9]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [49]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [50]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [51]
Milchsaure DM462BT Pruritus EC90 Investigative [52]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [53]
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Drug(s) Affected By Basigin (BSG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
Benzatropine DMF7EXL Parkinsonian disorder Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [64]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [39]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [65]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [66]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [67]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [68]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [69]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [70]
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Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [78]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [79]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Verapamil DMA7PEW Angina pectoris BA40 Approved [81]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proteasome (PS) TTU7ZMG NOUNIPROTAC Modulator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
AN1-type zinc finger protein 2A OTTG7P8R ZFN2A_HUMAN Gene/Protein Processing [6]
Basigin (BSG) OTD0CVEC BASI_HUMAN Gene/Protein Processing [7]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Drug Response [8]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Gene/Protein Processing [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [9]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) OTU0NR39 COX8A_HUMAN Gene/Protein Processing [9]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Gene/Protein Processing [9]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [10]

References

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2 Carfilzomib FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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40 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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43 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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59 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
60 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
61 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
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64 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
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72 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
73 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
74 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
75 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
76 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
77 Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
78 Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
79 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
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