Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4PUDW)

Drug Name

L-Glutamic Acid Drug Info

Synonyms

Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Approved	[1]

Therapeutic Class

Dietary supplement

Cross-matching ID

PubChem CID: 33032
ChEBI ID: CHEBI:16015
CAS Number: CAS 56-86-0
TTD Drug ID: DM4PUDW
VARIDT Drug ID: DR00005

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting N-methyl-D-aspartate receptor (NMDAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[20]
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[21]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[22]
Felbamate	DM1V5ZS	Epilepsy	8A60-8A68	Approved	[23]
Memantine	DMD9WSC	Alzheimer disease	8A20	Approved	[24]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[25]
Levorphanol	DMGS80V	Pain	MG30-MG3Z	Approved	[26]
Magnesium Sulfate	DMVEK07	Acute pain	MG31	Approved	[27]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[28]
Orphenadrine	DMW542E	Parkinson disease	8A00.0	Approved	[29]
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Drug(s) Transported By Organic anion transporter 4 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[32]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[33]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[34]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[35]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[36]
Levocetirizine	DMQYLGP	Allergic rhinitis	CA08.0	Approved	[37]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[31]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[38]
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Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[39]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[40]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[41]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[42]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[43]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[44]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[45]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[46]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[47]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[48]
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Drug(s) Transported By Vesicular glutamate transporter 2 (SLC17A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[49]
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Drug(s) Transported By Vesicular glutamate transporter 1 (SLC17A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[50]
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Drug(s) Transported By Organic cation transporter-like 3 (SLC22A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspartic acid	DMK7EYA	N. A.	N. A.	Investigative	[3]
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Drug(s) Transported By Putative sodium-coupled neutral amino acid transporter 10 (SLC38A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspartic acid	DMK7EYA	N. A.	N. A.	Investigative	[9]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[51]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[54]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[57]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[58]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[59]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[60]
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Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[61]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[65]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[66]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[73]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[76]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[79]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[51]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[57]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[81]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
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Drug(s) Affected By Transient receptor potential cation channel subfamily M member 4 (TRPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[90]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[93]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-methyl-D-aspartate receptor (NMDAR)	TT9IK2Z	NOUNIPROTAC	Antagonist	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter-like 3 (SLC22A13)	DT38SZL	S22AD_HUMAN	Substrate	[3]
Cystine/glutamate transporter (SLC7A11)	DTKLMH6	XCT_HUMAN	Substrate	[4]
Calcium-binding mitochondrial carrier protein Aralar2 (SLC25A13)	DTDSYAQ	CMC2_HUMAN	Substrate	[5]
Sodium-independent aspartate/glutamate transporter 1 (SLC7A13)	DTMWE5P	S7A13_HUMAN	Substrate	[6]
Calcium-binding mitochondrial carrier protein Aralar1 (SLC25A12)	DT85HYR	CMC1_HUMAN	Substrate	[7]
Putative sodium-coupled neutral amino acid transporter 8 (SLC38A8)	DT0UQDA	S38A8_HUMAN	Substrate	[8]
Putative sodium-coupled neutral amino acid transporter 10 (SLC38A10)	DT2LGOY	S38AA_HUMAN	Substrate	[9]
Excitatory amino acid transporter 4 (SLC1A6)	DTV2AOB	EAA4_HUMAN	Substrate	[10]
Excitatory amino acid transporter 1 (SLC1A3)	DT9U216	EAA1_HUMAN	Substrate	[10]
Vesicular glutamate transporter 1 (SLC17A7)	DTNK0FR	VGLU1_HUMAN	Substrate	[11]
Vesicular glutamate transporter 2 (SLC17A6)	DT5LHCR	VGLU2_HUMAN	Substrate	[11]
Mitochondrial glutamate carrier 1 (SLC25A22)	DTJCWP8	GHC1_HUMAN	Substrate	[12]
Mitochondrial glutamate carrier 2 (SLC25A18)	DT3VZJO	GHC2_HUMAN	Substrate	[13]
Excitatory amino acid transporter 5 (SLC1A7)	DTBGZ8H	EAA5_HUMAN	Substrate	[10]
Vesicular glutamate transporter 3 (SLC17A8)	DTAGDH7	VGLU3_HUMAN	Substrate	[11]
Excitatory amino acid transporter 2 (SLC1A2)	DT0VAI5	EAA2_HUMAN	Substrate	[14]
Excitatory amino acid transporter 3 (SLC1A1)	DTJIRMD	EAA3_HUMAN	Substrate	[15]
Organic anion transporter 4 (SLC22A11)	DT06JWZ	S22AB_HUMAN	Substrate	[16]
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[17]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[18]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[18]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[18]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[18]
Transient receptor potential cation channel subfamily M member 4 (TRPM4)	OT354X8E	TRPM4_HUMAN	Gene/Protein Processing	[19]

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References

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