Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4RVGO)

Drug Name

H-89 Drug Info

Synonyms

H 89

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 449241
ChEBI ID: CHEMBL104264
CAS Number: CAS 127243-85-0
TTD Drug ID: DM4RVGO

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting PRKACA messenger RNA (PRKACA mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VFEDEOUBYBLDKN-AAFJCEBUSA-N	DMH9ION	N. A.	N. A.	Patented	[9]
XHPNYYOUZWOWNT-PYUWXLGESA-N	DM5Q93Y	N. A.	N. A.	Patented	[9]
AGGGWZCOULSEER-PYUWXLGESA-N	DM2L83Y	N. A.	N. A.	Patented	[9]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[10]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[11]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[12]
NM-PP1	DMS8H5Q	Discovery agent	N.A.	Investigative	[13]
ISIS 102633	DMWT7BK	Discovery agent	N.A.	Investigative	[14]
ISIS 102604	DMZ6X9B	Discovery agent	N.A.	Investigative	[14]
ISIS 102619	DMXH9IT	Discovery agent	N.A.	Investigative	[14]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[15]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[17]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[18]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[19]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[20]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[21]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[22]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[23]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[21]
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Drug(s) Affected By Secretin (SCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[30]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[31]
Pentagastrin	DMRCLZB	Diagnostic imaging	N.A.	Approved	[32]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[33]
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Drug(s) Affected By cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[30]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[42]
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Drug(s) Affected By E3 ubiquitin-protein ligase RNF187 (RNF187)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[4]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[4]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[50]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PRKACA messenger RNA (PRKACA mRNA)	TT5U49F	KAPCA_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[2]
cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)	OTZ7P17Z	KAP2_HUMAN	Post-Translational Modifications	[3]
E3 ubiquitin-protein ligase RNF187 (RNF187)	OTXTN1HP	RN187_HUMAN	Protein Interaction/Cellular Processes	[4]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[5]
Patatin-like phospholipase domain-containing protein 6 (PNPLA6)	OTT5T45Q	PLPL6_HUMAN	Gene/Protein Processing	[6]
Secretin (SCT)	OTV3MLOO	SECR_HUMAN	Gene/Protein Processing	[7]
Tyrosinase	OTX54MAA	TYRO_HUMAN	Gene/Protein Processing	[8]

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References

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