Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4UAPD)

Drug Name
Clemizole Drug Info
Synonyms
Clemizole; 442-52-4; Histacur; Clemizol; Histakool; Lergopenin; Clemizolum; Depocural; 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole; 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole; NSC 46261; UNII-T97CB3796L; CHEBI:52140; CJXAEXPPLWQRFR-UHFFFAOYSA-N; T97CB3796L; 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole; 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-; 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole
Indication
Disease Entry ICD 11 Status REF
Hepatitis C virus infection 1E51.1 Phase 1 [1]
Cross-matching ID
PubChem CID
2782
ChEBI ID
CHEMBL1407943
CAS Number
CAS 442-52-4
TTD Drug ID
DM4UAPD
INTEDE Drug ID
DR2274

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [4]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [5]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [6]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [8]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [9]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [10]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [11]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [5]
Verapamil DMA7PEW Angina pectoris BA40 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [13]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [14]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [17]
Fluoxetine DM3PD2C Bipolar depression Approved [14]
Fructose DM43AN2 Vomiting MD90 Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [14]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [20]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [23]
Etidronic acid DM1XHYJ Bone Paget disease Approved [20]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [20]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [25]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [31]
Leflunomide DMR8ONJ Arthritis FA20 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [29]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [31]
Leflunomide DMR8ONJ Arthritis FA20 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [35]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [35]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [37]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Artemether DM48QOT Malaria 1F40-1F45 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [42]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [43]
Estrone DM5T6US Acne vulgaris ED80 Approved [44]
Leflunomide DMR8ONJ Arthritis FA20 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
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Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [35]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [35]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [3]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [3]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatitis C virus Non-structural 4B (HCV NS4B) TTALKDS POLG_HCV1 Modulator [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Gene/Protein Processing [3]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [3]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Protein Interaction/Cellular Processes [3]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Gene/Protein Processing [3]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Gene/Protein Processing [3]
Thyroid hormone-inducible hepatic protein (THRSP) OTKYE01L THRSP_HUMAN Gene/Protein Processing [3]

References

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20 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
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27 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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30 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
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