General Information of Drug (ID: DM53ZGY)

Drug Name
citral Drug Info
Synonyms geranial; geranialdehyde; citral a; trans-citral
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
638011
ChEBI ID
CHEBI:16980
CAS Number
CAS 5392-40-5
TTD Drug ID
DM53ZGY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SAR292833 DM63QY0 Pain MG30-MG3Z Phase 2 [9]
2-APB DM9AKVR Discovery agent N.A. Investigative [10]
diphenylboronic anhydride DMRQZTS Discovery agent N.A. Investigative [11]
aspirin-triggered resolvin D1 DMOP941 Discovery agent N.A. Investigative [12]
carvacrol DMINM2D Discovery agent N.A. Investigative [13]
cinnamaldehyde DMZDUXG Discovery agent N.A. Investigative [14]
diphenyltetrahydrofuran DMK8T61 Discovery agent N.A. Investigative [11]
carveol DMGIZ5U Discovery agent N.A. Investigative [15]
dihydrocarveol DMS4U68 Discovery agent N.A. Investigative [15]
tetrahydrocannabivarin DMDY1MZ Discovery agent N.A. Investigative [16]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [17]
2-APB DM9AKVR Discovery agent N.A. Investigative [17]
lysophosphatidylcholine DMOGFVH Discovery agent N.A. Investigative [18]
diphenylboronic anhydride DMRQZTS Discovery agent N.A. Investigative [17]
lysophosphatidylinositol DMETM3R Discovery agent N.A. Investigative [18]
cannabinol DMM6A7P Discovery agent N.A. Investigative [19]
TRIM DMNHU4M Discovery agent N.A. Investigative [17]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [30]
Diazepam DM08E9O Alcohol withdrawal Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [30]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [43]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [44]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [49]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [48]
Estrone DM5T6US Acne vulgaris ED80 Approved [53]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [54]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [54]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [57]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [60]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [61]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [62]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [22]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [68]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [66]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [70]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [43]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [80]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [86]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [89]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [90]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Gefitinib DM15F0X Colon adenocarcinoma Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Estrone DM5T6US Acne vulgaris ED80 Approved [93]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Mestranol DMG3F94 Contraception QA21 Approved [98]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [102]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [4]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [21]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transient receptor potential cation channel V2 (TRPV2) TTBECWA TRPV2_HUMAN Blocker (channel blocker) [2]
Transient receptor potential cation channel V3 (TRPV3) TT946IA TRPV3_HUMAN Activator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [3]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Gene/Protein Processing [4]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Protein Interaction/Cellular Processes [5]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Protein Interaction/Cellular Processes [5]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Gene/Protein Processing [4]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [3]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [6]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Gene/Protein Processing [7]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [8]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [6]

References

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27 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
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29 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
30 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
31 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
32 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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36 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
37 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
38 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
39 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
40 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
41 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
42 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
43 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
44 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
45 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
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48 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
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50 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
51 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
52 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
53 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
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56 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
57 The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.
58 Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. doi: 10.1034/j.1398-9995.2000.00803.x.
59 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
60 Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy. Rom J Gastroenterol. 2003 Jun;12(2):91-5.
61 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
62 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
63 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
64 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
65 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
66 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
67 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
68 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
69 Responsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives. Toxicol Appl Pharmacol. 2010 Jul;246(1-2):66-73. doi: 10.1016/j.taap.2010.04.007. Epub 2010 Apr 22.
70 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
71 A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals. Toxicology. 2009 Oct 1;264(1-2):1-9. doi: 10.1016/j.tox.2009.07.021. Epub 2009 Aug 7.
72 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
73 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
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