Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM56YN7)

Drug Name
Desloratadine Drug Info
Synonyms
Aerius; Allex; Azomyr; Claramax; Clarinex; Denosin; Desalex; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratidine; Neoclarityn; Opulis; Clarinex RediTabs; Desloratadine [USAN]; Essex brand of desloratadine; Schering brand of desloratadine; Sch 34117; Aerius (TN); Claramax (TN); Clarinex (TN); NeoClarityn (TN); Sch-34117; Schering-Plough brand of desloratadine; Desloratadine (USAN/INN); 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Common cold CA00 Approved [2]
Seasonal allergic rhinitis CA08.01 Approved [2]
Vasomotor/allergic rhinitis CA08 Approved [2]
Allergic urticaria Investigative [2]
Therapeutic Class
Antiallergic Agents
Cross-matching ID
PubChem CID
124087
ChEBI ID
CHEMBL1172
CAS Number
CAS 100643-71-8
TTD Drug ID
DM56YN7
VARIDT Drug ID
DR00497
INTEDE Drug ID
DR1761
ACDINA Drug ID
D00180

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [7]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [8]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [9]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [10]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [11]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [9]
Doxepin DMPI98T Anxiety Approved [12]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [9]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [13]
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [14]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [15]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Folic Acid DMEMBJC Colorectal carcinoma Approved [18]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [19]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [26]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [27]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [23]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 2B10 (UGT2B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pizotyline DMV74ZH Headache 8A80-8A84 Approved [30]
Cotinine DMCEZ1B Insecticide N.A. Approved [31]
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [35]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [36]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [37]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [36]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
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Drug(s) Affected By Hippocalcin-like protein 1 (HPCAL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Selenium DM25CGV N. A. N. A. Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [59]
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Drug(s) Affected By Glycylpeptide N-tetradecanoyltransferase 1 (NMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [63]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [5]
UDP-glucuronosyltransferase 2B10 (UGT2B10) DEI8NGH UDB10_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glycylpeptide N-tetradecanoyltransferase 1 (NMT1) OT42GQ3D NMT1_HUMAN Drug Response [6]
Hippocalcin-like protein 1 (HPCAL1) OTOBBFRD HPCL1_HUMAN Gene/Protein Processing [6]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [6]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Post-Translational Modifications [6]

References

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2 Desloratadine FDA Label
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63 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
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