Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM69G8X)

Drug Name

L-glutamine Drug Info

Synonyms

NutreStore; AES-14; Aesgen-14; Glutamine (INN); L-glutamine (oral, short bowel syndrome), Emmaus; L-glutamine (topical, chemotherapy-induced mucositis), Aesgen; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus/University of California Los Angeles

Indication

Disease Entry	ICD 11	Status	REF
Short bowel syndrome	KB89.1	Approved	[1]

Cross-matching ID

PubChem CID: 5961
ChEBI ID: CHEMBL18050
CAS Number: CAS 56-85-9
TTD Drug ID: DM69G8X
VARIDT Drug ID: DR00024

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[6]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[6]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[7]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[8]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[9]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[10]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[11]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[12]
L-threonine	DMFHTBX	Discovery agent	N.A.	Investigative	[12]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 1 (SLC38A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 3 (SLC38A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[13]
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[14]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 4 (SLC38A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 5 (SLC38A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
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Drug(s) Transported By Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[15]
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Drug(s) Transported By L-type amino acid transporter 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[16]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[17]
Pregabalin	DMDVP3B	Chronic obstructive pulmonary disease	CA22	Approved	[18]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[27]
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Drug(s) Affected By Latent-transforming growth factor beta-binding protein 1 (LTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
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⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3)	DTKWJH3	S38A3_HUMAN	Substrate	[2]
Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7)	DT2EGUN	S38A7_HUMAN	Substrate	[2]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5)	DTLX28N	S38A5_HUMAN	Substrate	[2]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4)	DTPJBD5	S38A4_HUMAN	Substrate	[2]
Sodium-coupled neutral amino acid transporter 2 (SLC38A2)	DTTWL58	S38A2_HUMAN	Substrate	[2]
Sodium-coupled neutral amino acid transporter 1 (SLC38A1)	DTD815L	S38A1_HUMAN	Substrate	[2]
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)	DTW7AE3	AAAT_HUMAN	Substrate	[3]
L-type amino acid transporter 1 (SLC7A5)	DT48T0N	LAT1_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Calnexin homolog 1 (CNX1)	OTLOSIX2	CALX1_ARATH	Drug Response	[5]
Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)	OTQBDO45	GFPT1_HUMAN	Drug Response	[5]
Latent-transforming growth factor beta-binding protein 1 (LTBP1)	OTR7Q75L	LTBP1_HUMAN	Drug Response	[5]

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References

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19	Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
20	Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
21	Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
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27	Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
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29	Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
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33	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
34	Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
35	Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
36	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
37	Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.