Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8IC5H)

Drug Name

TRICIRIBINE Drug Info

Synonyms

NSC154020; Akt Inhibitor V, Triciribine; MLS002702033; Akt/PKB Signaling Inhibitor-2; NSC-154020; TCN; Akt inhibitor V; AC1Q7CGY; AC1L6DVE; tricyclic nucleoside (TCN); SCHEMBL61269; GTPL5920; CHEMBL1892348; CHEBI:91697; HMS3268N05; HMS3654C06; HMS3229A09; HSCI1_000386; CCG-206732; 5-methyl-1-pentofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine; SMR001565606; SC-89664; NCI60_001091; Akt/protein kinase B signaling inhibitor-2; BRD-A42649439-001-01-0; BRD-A42649439-001-02-8; 1,5,6,8-Pentaazaacennaphthylen-3-amine, 1,5-dih

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 65399
ChEBI ID: CHEBI:65310
CAS Number: CAS 35943-35-2
TTD Drug ID: DM8IC5H
INTEDE Drug ID: DR1821

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[7]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[8]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[9]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[7]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[10]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[11]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[10]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[10]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[12]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[13]
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Drug(s) Affected By Follitropin subunit beta (FSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[14]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[15]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[16]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[17]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[18]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[19]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[20]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[21]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[28]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[29]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[28]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
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Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[36]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[43]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[46]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[50]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[51]
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Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[57]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[58]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[59]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[62]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[63]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[64]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[68]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[69]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Adenosine kinase (ADK)^{Main DME}	DE7T5VX	ADK_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Gene/Protein Processing	[5]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[4]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Gene/Protein Processing	[4]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[6]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Post-Translational Modifications	[6]

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References

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