Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA4NI2)

Drug Name

Dimaprit Drug Info

Synonyms

Dimaprit; 65119-89-3; UNII-ZZQ699148P; BRN 2350552; CHEMBL12344; 3-(dimethylamino)propyl imidothiocarbamate; 3-(dimethylamino)propyl carbamimidothioate; CARBAMIMIDOTHIOIC ACID, 3-(DIMETHYLAMINO)PROPYL ESTER; CHEBI:81389; ZZQ699148P; Pseudourea, 2-(3-(dimethylamino)propyl)-2-thio-; [3-(carbamimidoylsulfanyl)propyl]dimethylamine; Carbamimidothioicacid, 3-(dimethylamino)propyl ester; C6H15N3S; AE-641/25069014; Tocris-0506; AC1Q1UAQ; Prestwick0_000983; Prestwick3_000983; Prestwick2_000983; Prestwick1_000983; AC1L1F4E; BSPBio_001045

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3077
ChEBI ID: CHEBI:81389
CAS Number: CAS 65119-89-3
TTD Drug ID: DMA4NI2

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Histamine H2 receptor (H2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[6]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[7]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[7]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[8]
Betazole	DMUFGAY	Gastric secretory disorder	DD90	Approved	[9]
Ebrotidine	DMV5KR3	Duodenal ulcer	DA63	Withdrawn from market	[10]
Pibutidine	DMXSTRM	Ulcerative colitis	DD71	Discontinued in Phase 3	[11]
Osutidine	DMN7TL8	Duodenal ulcer	DA63	Discontinued in Phase 3	[12]
KU-1257	DMZMFX6	Duodenal ulcer	DA63	Discontinued in Phase 3	[13]
Lavoltidine	DMTY5VE	Gastroesophageal reflux disease	DA22.Z	Discontinued in Phase 2	[14]
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Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[28]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
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Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[32]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[34]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[40]
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Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[41]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[42]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[49]
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Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Fructose	DM43AN2	Vomiting	MD90	Approved	[52]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
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Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[64]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[65]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H2 receptor (H2R)	TTQHJ1K	HRH2_HUMAN	Agonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Gene/Protein Processing	[3]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Gene/Protein Processing	[3]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[4]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Gene/Protein Processing	[5]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Gene/Protein Processing	[4]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Gene/Protein Processing	[4]

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References

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