Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ2Z9G)

Drug Name
2-Amino-1-(4-methylthiophenyl)propane Drug Info
Synonyms 1-(6-(methylthio)naphthalen-2-yl)propan-2-amine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
151900
CAS Number
CAS 14116-06-4
TTD Drug ID
DMJ2Z9G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Norepinephrine transporter (NET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [4]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [4]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [7]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [8]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [9]
Venlafaxine DMR6QH0 Anxiety disorder 6B00-6B0Z Approved [8]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [10]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [11]
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Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [4]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [5]
Fluoxetine DM3PD2C Bipolar depression Approved [12]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [13]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [7]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [8]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [12]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [12]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [12]
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Drug(s) Targeting Dopamine transporter (DAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [7]
Dasotraline DMLDQFV Attention deficit hyperactivity disorder 6A05.Z Approved [15]
Methylphenidate DM7SJD6 Attention deficit hyperactivity disorder 6A05.Z Approved [16]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [12]
Phenmetrazine DMXYTN9 Obesity 5B81 Approved [17]
Ioflupane i-123 DMNARJT Parkinson disease 8A00.0 Approved [18]
DEXMETHYLPHENIDATE HYDROCHLORIDE DM8WBAH Attention deficit hyperactivity disorder 6A05.Z Approved [19]
Altropane DMO9WDS Attention deficit hyperactivity disorder 6A05.Z Approved [20]
Amitifadine DMS1X67 Obesity 5B81 Phase 3 [21]
NAV5001 DMRSI1M Dementia 6D80-6D86 Phase 3 [20]
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Drug(s) Targeting Monoamine oxidase type A (MAO-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [22]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [23]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [24]
Isocarboxazid DMAF1NB Depression 6A70-6A7Z Approved [25]
TRYPTAMINE DMAFPHB N. A. N. A. Phase 3 [26]
Psoralen DMIZJ8M N. A. N. A. Phase 3 [27]
CHF-3381 DMQ2O8V Neuropathic pain 8E43.0 Phase 2 [28]
Ladostigil DMJSY3Q Alzheimer disease 8A20 Phase 2 [29]
CX157 DMS2WB5 Mood disorder 6A60-6E23 Phase 2 [30]
PIPERINE DMYEAB1 Vitiligo ED63.0 Phase 1/2 [31]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [36]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [40]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [42]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [42]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [63]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [64]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Meloxicam DM2AR7L Arthritis FA20 Approved [67]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [68]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [71]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [82]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [83]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [87]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [88]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [89]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [40]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Inhibitor [2]
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [2]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [3]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [3]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Gene/Protein Processing [3]

References

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70 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
71 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
72 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
73 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
74 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
75 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
76 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
77 Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
78 Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
79 Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
80 Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
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