Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJK5CT)

Drug Name

STX-140 Drug Info

Synonyms

(9beta,13alpha,14beta,17alpha)-2-Methoxyestra-1,3,5(10)-Triene-3,17-Diyl Disulfamate; STX140; CHEMBL218382; 2-MeOE2bisMATE; 2-methoxyestradiol-3,17-O,O-bis-sulfamate; STX 140; 2-MeOEbisMATE; 2gd8; 2-methoxyestradiol 3,17-O,O-bis-sulfamate; 2-MbM; 2-methoxyestradiol-3,17-O,O-bis(sulfamate); SCHEMBL446846; BDBM50200936; DB08416; (9beta,17beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate; Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, disulfamate, (17beta)-; 401600-86-0; Angiomates; Estrone sulphatase inhibitors, Ipsen; STX-213; STX-641; Steroid sulfatase inhibitors, Sterix Ltd; 2-MeOE2-bis MATE; 2-MeSEMATE; 2-ethyl-estradiol bis-sulfamate; 2-methoxyestradiol, Sterix; 2-methoxyestradiol-bis-sulfamate; 2-methoxyestradiol-bis-sulfamate, Sterix

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Phase 2	[1]

Cross-matching ID

PubChem CID: 9804302
ChEBI ID: CHEMBL218382
CAS Number: CAS 401600-86-0
TTD Drug ID: DMJK5CT

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[8]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[9]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[10]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[10]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[11]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[12]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
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Drug(s) Targeting Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tranilast	DME5Y64	Allergic rhinitis	CA08.0	Approved	[15]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[16]
PGL-2001	DMKA705	Endometriosis	GA10	Phase 2	[17]
PGL-2	DMJTYO4	Endometriosis	GA10	Phase 2	[17]
STX 64	DMJAPRK	Prostate cancer	2C82.0	Phase 1	[18]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[19]
EMATE	DMFQX1U	Discovery agent	N.A.	Investigative	[20]
Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester	DMM70K1	Discovery agent	N.A.	Investigative	[21]
Estradiol 17-O-sulfamate	DM7K14V	Discovery agent	N.A.	Investigative	[3]
4-Sulfamoyloxy-benzoic acid pentyl ester	DMZIFW7	Discovery agent	N.A.	Investigative	[22]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[26]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[36]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[36]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[47]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Steryl-sulfatase (STS)	TTHM0R1	STS_HUMAN	Inhibitor	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[4]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Protein Interaction/Cellular Processes	[5]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[4]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[5]

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References

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