Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJK5CT)

Drug Name
STX-140 Drug Info
Synonyms
(9beta,13alpha,14beta,17alpha)-2-Methoxyestra-1,3,5(10)-Triene-3,17-Diyl Disulfamate; STX140; CHEMBL218382; 2-MeOE2bisMATE; 2-methoxyestradiol-3,17-O,O-bis-sulfamate; STX 140; 2-MeOEbisMATE; 2gd8; 2-methoxyestradiol 3,17-O,O-bis-sulfamate; 2-MbM; 2-methoxyestradiol-3,17-O,O-bis(sulfamate); SCHEMBL446846; BDBM50200936; DB08416; (9beta,17beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate; Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, disulfamate, (17beta)-; 401600-86-0; Angiomates; Estrone sulphatase inhibitors, Ipsen; STX-213; STX-641; Steroid sulfatase inhibitors, Sterix Ltd; 2-MeOE2-bis MATE; 2-MeSEMATE; 2-ethyl-estradiol bis-sulfamate; 2-methoxyestradiol, Sterix; 2-methoxyestradiol-bis-sulfamate; 2-methoxyestradiol-bis-sulfamate, Sterix
Indication
Disease Entry ICD 11 Status REF
Osteoporosis FB83.0 Phase 2 [1]
Cross-matching ID
PubChem CID
9804302
CAS Number
CAS 401600-86-0
TTD Drug ID
DMJK5CT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [10]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [11]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [12]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [13]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [13]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [14]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [15]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [16]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [17]
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Drug(s) Targeting Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [18]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [19]
PGL-2001 DMKA705 Endometriosis GA10 Phase 2 [20]
PGL-2 DMJTYO4 Endometriosis GA10 Phase 2 [20]
STX 64 DMJAPRK Prostate cancer 2C82.0 Phase 1 [21]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [22]
EMATE DMFQX1U Discovery agent N.A. Investigative [23]
Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester DMM70K1 Discovery agent N.A. Investigative [24]
Estradiol 17-O-sulfamate DM7K14V Discovery agent N.A. Investigative [3]
4-Sulfamoyloxy-benzoic acid pentyl ester DMZIFW7 Discovery agent N.A. Investigative [25]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Gefitinib DM15F0X Colon adenocarcinoma Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [29]
Etretinate DM2CZFA Keratosis ED56 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [32]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [36]
Epinephrine DM3KJBC Acute asthma CA23 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [40]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [41]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [43]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [29]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [49]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [49]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [51]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Etretinate DM2CZFA Keratosis ED56 Approved [30]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
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Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [64]
Haloperidol DM96SE0 Delirium Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Clozapine DMFC71L Schizophrenia 6A20 Approved [65]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Orlistat DMRJSP8 Obesity 5B81 Approved [68]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [71]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [72]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [73]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [74]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [76]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [77]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [78]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [82]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [85]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [91]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [95]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [2]
Steryl-sulfatase (STS) TTHM0R1 STS_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Protein Interaction/Cellular Processes [5]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [4]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [4]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Gene/Protein Processing [7]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [5]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Gene/Protein Processing [8]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Gene/Protein Processing [8]

References

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51 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
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63 Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
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