Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLEDNK)

Drug Name
Carbenicillin Drug Info
Synonyms
CBPC; Carbenicilina; Carbenicillina; Carbenicilline; Carbenicillinum; Carboxybenzylpenicillin; Pyopen; Carbenicillina [DCIT]; Carboxybenzyl Penicillin; Carboxybenzylpenicillin acid; Alpha-Carboxybenzylpencillin; Alpha-Carboxybenzylpenicillin solution; Carbenicilina [INN-Spanish]; Carbenicillin (INN); Carbenicillin [INN:BAN]; Carbenicilline [INN-French]; Carbenicillinum [INN-Latin]; Alpha-Phenyl(carboxymethylpenicillin); N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid;N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid; (2S,5R,6R)-6-[(3-hydroxy-3-oxo-2-phenylpropanoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(alpha-Carboxyphenylacetamido)penicillanic acid; 6beta-(2-carboxy-2-phenylacetamido)-2,2-dimethylpenam-3alpha-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Infection of the upper and lower urinary tract GC08 Approved [1]
Prostatitis Approved [2]
Urinary tract infection GC08 Approved [2]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
20824
ChEBI ID
CHEBI:3393
CAS Number
CAS 4697-36-3
TTD Drug ID
DMLEDNK
VARIDT Drug ID
DR00995
INTEDE Drug ID
DR2390

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ampicillin DMHWE7P Acute epiglottitis Approved [9]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [10]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [11]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [12]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [13]
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [11]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [14]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [15]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [16]
Piperacillin DMTBKF3 Acute gonococcal cervicitis Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By N-acylhomoserine lactone acylase (lacA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [4]
Ampicillin DMHWE7P Acute epiglottitis Approved [4]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [4]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [4]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [4]
Drug(s) Metabolized By Beta-lactamase (blaB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ampicillin DMHWE7P Acute epiglottitis Approved [7]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [6]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [6]
Drug(s) Metabolized By PenA beta-lactamase (penA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxacillin DMTAFY4 Bacterial infection 1A00-1C4Z Approved [5]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
N-acylhomoserine lactone acylase (lacA) DEIU0XN A0A0A1VBK6_9BURK Substrate [4]
PenA beta-lactamase (penA1) DE2ARDZ O08350_BURCE Substrate [5]
Beta-lactamase (blaB) DEF01WC A0A3S4HKA9_CHRVL Substrate [6]
Beta-lactamase (blaB) DEXB2A9 A0A379CPC3_PLESH Substrate [7] , [8]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Carbenicillin FDA Label
3 Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.
4 A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17.
5 Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.
6 Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3.
7 Beta-lactamase expression in Plesiomonas shigelloides. J Antimicrob Chemother. 2000 Jun;45(6):877-80.
8 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
9 Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80.
10 Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9.
11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
12 Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus. Jpn J Antibiot. 1993 Jun;46(6):421-7.
13 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
14 Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32.
15 Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.
16 Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21.
17 In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enter... J Infect Dis. 2004 Dec 15;190(12):2162-6.