Details of the Drug-Related molecule(s) Interaction Atlas

Adefovir Drug Info

((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid; 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid; 9-(2-(Phosphonomethoxy)ethyl)adenine; 9-(2-Phosphonylmethoxyethyl)adenine; ADEFOVIR; GS 0393; GS 393; GS-0393; N-(2-Phophonomethoxyethyl-2,6-diaminopurine); N-(2-Phosphonylmethoxyethyl)adenine; PMEA; {[2-(6-Amino-9h-Purin-9-Yl)ethoxy]methyl}phosphonic Acid

Cross-matching ID

PubChem CID

60172

ChEBI ID

CHEBI:2469

CAS Number

CAS 106941-25-7

TTD Drug ID

DMM278X

VARIDT Drug ID

DR00015

General Information of Drug (ID: DMM278X)

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[3]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[13]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[14]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[15]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[16]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[26]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[29]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
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Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[3]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[40]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[41]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[43]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[3]
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Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[47]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[47]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[48]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[49]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[50]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[51]
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Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[53]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[54]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[55]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[56]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[57]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[58]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[59]
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Drug(s) Affected By Band 3 anion transport protein (SLC4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[64]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[65]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[67]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[68]
Selenious acid	DMB7GPA	N. A.	N. A.	Investigative	[69]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[1]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[2]
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[3]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[5]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[6]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Band 3 anion transport protein (SLC4A1)	OT3EFUK8	B3AT_HUMAN	Drug Response	[7]

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