Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNORK8)

Drug Name
Jakafi Drug Info
Synonyms
Ruxolitinib phosphate; 1092939-17-7; Ruxolitinib (phosphate); Jakavi; (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate; UNII-436LRU32H5; Ruxolitinib phosphate salt; Ruxolitinib phosphate(INCB018424); CHEBI:66917; 436LRU32H5; J-501793; (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate; (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate; Ruxolitinib phosphate [USAN]; Jaka
Indication
Disease Entry ICD 11 Status REF
Essential thrombocythemia 3B63.1Z Phase 3 [1]
Cross-matching ID
PubChem CID
25127112
ChEBI ID
CHEBI:66917
CAS Number
CAS 1092939-17-7
TTD Drug ID
DMNORK8
INTEDE Drug ID
DR1454

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [8]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [9]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [12]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [13]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [14]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [15]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
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Drug(s) Affected By C-X-C motif chemokine 11 (CXCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [20]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [24]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [30]
Estrone DM5T6US Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [33]
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Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
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Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [41]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Clozapine DMFC71L Schizophrenia 6A20 Approved [52]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [53]
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Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [41]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [62]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [63]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [66]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [67]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 7 (IRF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [19]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [69]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [41]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Gene/Protein Processing [3]
C-X-C motif chemokine 11 (CXCL11) OT353XE3 CXL11_HUMAN Gene/Protein Processing [3]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Gene/Protein Processing [3]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Gene/Protein Processing [3]
Mitochondrial brown fat uncoupling protein 1 OT0XMVWH UCP1_HUMAN Gene/Protein Processing [4]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Gene/Protein Processing [3]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Post-Translational Modifications [5]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Gene/Protein Processing [6]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Gene/Protein Processing [6]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [7]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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8 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
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