Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO1URE)

Drug Name
SC-236 Drug Info
Synonyms SC-791; SC-872; COX-2 inhibitors (anticancer), Pfizer; COX-2 inhibitors (anticancer), Pharmacia
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Terminated [1]
Cross-matching ID
PubChem CID
9865808
ChEBI ID
CHEMBL282093
CAS Number
CAS 170569-86-5
TTD Drug ID
DMO1URE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [7]
Naproxen DMZ5RGV Bursitis Approved [8]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [9]
Indomethacin DMSC4A7 Bursitis Approved [10]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [11]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [12]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [13]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [14]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [15]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [16]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [19]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [17]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [22]
Paclitaxel DMLB81S Breast carcinoma Approved [23]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [29]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [24]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [32]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [41]
Selenium DM25CGV N. A. N. A. Approved [42]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [43]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [49]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein epsilon OT3WQXNA 1433E_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [4]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Gene/Protein Processing [5]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Drug Response [6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Gene/Protein Processing [6]

References

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22 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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30 Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
31 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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33 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
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37 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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42 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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