Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP8RQ4)

Drug Name	PMID26394986-Compound-10 Drug Info
Cross-matching ID	PubChem CID 252682 ChEBI ID CHEBI:91224 CAS Number CAS 501919-59-1 TTD Drug ID DMP8RQ4

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Patented Agent(s)

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Signal transducer and activator of transcription 5 (STAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Platinum IV complexe 1	DM8OYI4	N. A.	N. A.	Patented	[1]
PMID26394986-Compound-56	DMPNJ4X	N. A.	N. A.	Patented	[1]
Indirubin derivative 1	DMB8673	N. A.	N. A.	Patented	[1]
PMID26394986-Compound-57	DMILUT8	N. A.	N. A.	Patented	[1]
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Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[5]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[6]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[7]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[8]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[6]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[9]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[10]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[6]
GLG-801	DMY1CP9	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[6]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
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Drug(s) Targeting Signal transducer and activator of transcription 1 (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Platinum IV complexe 1	DM8OYI4	N. A.	N. A.	Patented	[1]
Oxazole derivative 1	DM7Y2RL	N. A.	N. A.	Patented	[1]
Peptidomimetic analog 5	DMF0DE2	N. A.	N. A.	Patented	[1]
Peptide analog 8	DMFG7A8	N. A.	N. A.	Patented	[1]
AVT-02 UE	DM8NA4M	Skin infection	1F28-1G0Z	Discontinued in Phase 2	[12]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[18]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[19]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
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Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[25]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[26]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[30]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[31]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
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Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[56]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[59]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[63]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[64]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[70]
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Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[73]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Signal transducer and activator of transcription 1 (STAT1)	TTN7R6K	STAT1_HUMAN	Inhibitor	[1]
Signal transducer and activator of transcription 3 (STAT3)	TTH8FZW	STAT3_HUMAN	Inhibitor	[1]
Signal transducer and activator of transcription 5 (STAT5)	TTLRFIH	STA5A_HUMAN; STA5B_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[2]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[2]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[3]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[3]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[4]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Gene/Protein Processing	[2]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Gene/Protein Processing	[4]
Vimentin	OTGZLW4J	VIME_HUMAN	Gene/Protein Processing	[2]

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