Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQXTJS)

Drug Name
Eptifibatide Drug Info
Synonyms
Integrelin; Integrilin; Intrifiban; HS-2011; Integrilin (TN); SB-1; Sch-60936; N(6)-amidino-N(2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide; N(sup 6)-Amidino-N(sup 2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide; S(1),S(6)-cyclo[N(6)-carbamimidoyl-N(2)-(3-sulfanylpropanoyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide]; L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic (1-6)-disulfide; L-Cysteinamide,N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-propyl-,cyclic (1-6)-disulfide; [(3R,11S,17S,20S,25aS)-11-(4-carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid; 2-[(3S,6S,12S,20R,23S)-20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid; 2-[20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid
Indication
Disease Entry ICD 11 Status REF
Acute cardiac ischemic events BA40.Z Approved [1]
Acute coronary syndrome BA41 Approved [2]
Pneumonia CA40 Approved [2]
Therapeutic Class
Anticoagulants
Cross-matching ID
PubChem CID
448812
ChEBI ID
CHEBI:291902
CAS Number
CAS 188627-80-7
TTD Drug ID
DMQXTJS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [6]
Tirofiban DMQG17S Acute coronary syndrome BA41 Approved [7]
Abciximab DMJO6GV Acute disease Approved [7]
DMP-444 DMO7BQS Coronary artery disease BA80 Phase 3 [8]
99mTc-rBitistatin DMFAMNH Pulmonary embolism JB42 Phase 1/2 [9]
AjvW2 DM6PN4H Thrombosis DB61-GB90 Phase 1 [10]
SDZ-GPI-562 DMU9ZGN Thrombosis DB61-GB90 Phase 1 [11]
RGD-891 DMVJMF1 Thrombosis DB61-GB90 Phase 1 [12]
Lefradafiban DMKZVLH Angina pectoris BA40 Phase 1 [13]
XEMILOFIBAN DMBRYT8 Cardiovascular disease BA00-BE2Z Discontinued in Phase 3 [14]
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Drug(s) Affected By Prothrombin (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [19]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [20]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Testosterone enanthate DMB6871 N. A. N. A. Approved [23]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [24]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [5]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [28]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [29]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [30]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [31]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [34]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [37]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [41]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
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Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [44]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [45]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [46]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [47]
Menthol DMG2KW7 Back pain ME84.Z Approved [48]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [47]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [50]
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Drug(s) Affected By Integrin alpha-IIb (ITGA2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [46]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [55]
Abciximab DMJO6GV Acute disease Approved [5]
Tirofiban DMQG17S Acute coronary syndrome BA41 Approved [5]
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Drug(s) Affected By Integrin beta-3 (ITGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [53]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [63]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) TT38RM1 ITA2B_HUMAN; ITB3_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [4]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Gene/Protein Processing [4]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Drug Response [5]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Drug Response [5]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [4]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Gene/Protein Processing [4]

References

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2 Eptifibatide FDA Label
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