General Information of Drug (ID: DMRPZD4)

Drug Name
HPTE Drug Info
Synonyms
Hydroxychlor; HPTE; p,p'-Hydroxy-DDT; 2971-36-0; p,p'-HO-DDT; 2,2-Bis(4-hydroxyphenyl)-1,1,1-trichloroethane; 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane; 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol; 2,2-Bis(p-hydroxyphenyl)-1,1,1-trichloroethane; 4,4'-(2,2,2-Trichloroethylidene)diphenol; 1,1-Bis(4-hydroxyphenyl)-2,2,2-trichloroethane; 1,1-Bis(p-hydroxyphenyl)-2,2,2-trichloroethane; p,p'-(2,2,2-Trichloroethylidene)diphenol; NSC 7045; 1,1,1-Trichloro-2,2-bis(p-hydroxyphenyl)ethane; Phenol, 4,4'-(2,2,2-trichloroethylid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
76302
ChEBI ID
CHEBI:34025
CAS Number
CAS 2971-36-0
TTD Drug ID
DMRPZD4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [12]
Trilostane DMQZ9GF Cushing disease 5A70 Approved [13]
ARZOXIFENE DMOKCVI Breast cancer 2C60-2C65 Approved [14]
Estrogen DMGY0UT Menopause symptom GA30.0 Approved [15]
MF-101 DM8Z0I3 Hepatitis virus infection 1E50-1E51 Phase 3 [16]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [17]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [18]
ERB-041 DMCEPUA Inflammatory bowel disease DD72 Phase 2 [19]
Erteberel DMU1XZD Prostate hyperplasia GA90 Phase 2 [20]
VG-101 DMAN21O Menopause symptom GA30.0 Phase 1/2 [21]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [27]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [28]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [29]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [35]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Fluoxetine DM3PD2C Bipolar depression Approved [32]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [40]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [39]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [51]
Ethanol DMDRQZU Chronic pain MG30 Approved [52]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [53]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [54]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [57]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [58]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [59]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [59]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [60]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [63]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [64]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [65]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [77]
Gefitinib DM15F0X Colon adenocarcinoma Approved [78]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [81]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [82]
Paclitaxel DMLB81S Breast carcinoma Approved [83]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [84]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
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Drug(s) Affected By CCN family member 5 (CCN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [87]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [38]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [88]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [89]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [90]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [91]
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Drug(s) Affected By Serine protease 23 (PRSS23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Panobinostat DM58WKG Chronic graft versus host disease Approved [94]
Estrone DM5T6US Acne vulgaris ED80 Approved [95]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [98]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [64]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [102]
Estrone DM5T6US Acne vulgaris ED80 Approved [106]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Estrone DM5T6US Acne vulgaris ED80 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [112]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [109]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [114]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [115]
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Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Estrone DM5T6US Acne vulgaris ED80 Approved [119]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [120]
Testosterone DM7HUNW Hot flushes GA30 Approved [121]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [115]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [122]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [125]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [125]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [125]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [126]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [127]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [128]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [129]
Selenium DM25CGV N. A. N. A. Approved [130]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [94]
Estrone DM5T6US Acne vulgaris ED80 Approved [95]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [136]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Testosterone enanthate DMB6871 N. A. N. A. Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [39]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [142]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [143]
Arsenic DMTL2Y1 N. A. N. A. Approved [144]
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Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [146]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [145]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [109]
Mestranol DMG3F94 Contraception QA21 Approved [145]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [147]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [148]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [151]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor beta (ESR2) TTOM3J0 ESR2_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Gene/Protein Processing [3]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [3]
17-beta-hydroxysteroid dehydrogenase type 3 (HSD17B3) OT45D396 DHB3_HUMAN Gene/Protein Processing [4]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [5]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [6]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Drug Response [7]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Gene/Protein Processing [8]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Post-Translational Modifications [9]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [10]
Estrogen-related receptor gamma (ESRRG) OTC3A0KU ERR3_HUMAN Protein Interaction/Cellular Processes [11]

References

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3 Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11beta-hydroxysteroid dehydrogenase activities in vitro. Toxicol Lett. 2013 Mar 27;218(1):18-23.
4 Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase-3 activities in human and rat testes. Int J Androl. 2011 Apr;34(2):138-44.
5 Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening. Toxicol Sci. 2002 Mar;66(1):82-90. doi: 10.1093/toxsci/66.1.82.
6 A comparison of two human cell lines and two rat gonadal cell primary cultures as in vitro screening tools for aromatase modulation. Toxicol In Vitro. 2012 Feb;26(1):107-18.
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8 Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect. 2013 Apr;121(4):459-66. doi: 10.1289/ehp.1205951. Epub 2013 Feb 5.
9 Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis. 2017 Mar 1;38(3):252-260.
10 Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol. 2010 Mar 15;23(3):578-90. doi: 10.1021/tx900325g.
11 Structure-based Identification of Endocrine Disrupting Pesticides Targeting Breast Cancer Proteins. Toxicology. 2020 Jun;439:152459. doi: 10.1016/j.tox.2020.152459. Epub 2020 Apr 9.
12 Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85.
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14 Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11):2682-92.
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18 S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9.
19 Erb-041, an estrogen receptor-beta agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98.
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21 Update on alternative therapies for vulvovaginal atrophy. Patient Prefer Adherence. 2011; 5: 533-536.
22 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
23 Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7.
24 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
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26 17beta-hydroxysteroid dehydrogenase-3 deficiency: a rare endocrine cause of male-to-female sex reversal. Gynecol Endocrinol. 2006 Sep;22(9):488-94.
27 Androgen receptor modulation following combination exposure to brominated flame-retardants. Sci Rep. 2018 Mar 19;8(1):4843. doi: 10.1038/s41598-018-23181-0.
28 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
29 The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells. Environ Toxicol. 2021 Apr;36(4):665-674. doi: 10.1002/tox.23070. Epub 2020 Dec 1.
30 Aromatase inhibition: translation into a successful therapeutic approach. Clin Cancer Res. 2005 Apr 15;11(8):2809-21. doi: 10.1158/1078-0432.CCR-04-2187.
31 Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. Reprod Toxicol. 2020 Apr;93:75-82. doi: 10.1016/j.reprotox.2020.01.003. Epub 2020 Jan 14.
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33 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
34 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
35 Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 10;48(5):1563-75.
36 Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004 Aug;30(3):387-94.
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38 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
39 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
40 Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
41 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
42 Testosterone stimulates adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children. J Clin Endocrinol Metab. 2010 Jul;95(7):3300-8.
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