Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRPZD4)

Drug Name
HPTE Drug Info
Synonyms
Hydroxychlor; HPTE; p,p'-Hydroxy-DDT; 2971-36-0; p,p'-HO-DDT; 2,2-Bis(4-hydroxyphenyl)-1,1,1-trichloroethane; 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane; 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol; 2,2-Bis(p-hydroxyphenyl)-1,1,1-trichloroethane; 4,4'-(2,2,2-Trichloroethylidene)diphenol; 1,1-Bis(4-hydroxyphenyl)-2,2,2-trichloroethane; 1,1-Bis(p-hydroxyphenyl)-2,2,2-trichloroethane; p,p'-(2,2,2-Trichloroethylidene)diphenol; NSC 7045; 1,1,1-Trichloro-2,2-bis(p-hydroxyphenyl)ethane; Phenol, 4,4'-(2,2,2-trichloroethylid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
76302
ChEBI ID
CHEMBL196585
CAS Number
CAS 2971-36-0
TTD Drug ID
DMRPZD4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [6]
Trilostane DMQZ9GF Cushing disease 5A70 Approved [7]
ARZOXIFENE DMOKCVI Breast cancer 2C60-2C65 Approved [8]
Estrogen DMGY0UT Menopause symptom GA30.0 Approved [9]
MF-101 DM8Z0I3 Hepatitis virus infection 1E50-1E51 Phase 3 [10]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [11]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [12]
ERB-041 DMCEPUA Inflammatory bowel disease DD72 Phase 2 [13]
Erteberel DMU1XZD Prostate hyperplasia GA90 Phase 2 [14]
VG-101 DMAN21O Menopause symptom GA30.0 Phase 1/2 [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 3 (HSD17B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [17]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [20]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [22]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [23]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [30]
Gefitinib DM15F0X Colon adenocarcinoma Approved [31]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [34]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [35]
Paclitaxel DMLB81S Breast carcinoma Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 5 (CCN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [42]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [42]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [45]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine protease 23 (PRSS23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [51]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [55]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [59]
Mestranol DMG3F94 Contraception QA21 Approved [55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor beta (ESR2) TTOM3J0 ESR2_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 3 (HSD17B3) OT45D396 DHB3_HUMAN Gene/Protein Processing [3]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Gene/Protein Processing [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Gene/Protein Processing [4]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Gene/Protein Processing [4]

References

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