Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS7T13)

Drug Name

Meclizine Drug Info

Synonyms

Ancolan; Ancolon; Antivert; Bonadettes; Bonine; Calmonal; Chiclida; Diadril; Histamethine; Histamethizine; Histametizine; Histametizyn; Histametizyne; Itinerol; Marex; Meclicot; Meclozina; Meclozine; Meclozinum; Medivert; Monamine; Navicalm; Nevidoxine; Parachloramine; Peremesin; Postafene; Ravelon; Sabari; Siguran; Subari; Suprimal; Travelon; Veritab; Vomisseis; Vomissels; Dramamine II; Meclizine Hcl; UCB 170; UCB 5052; UCB 5062; Antivert (TN); Antivert/25; Antivert/50; Bonamine (TN); Bonine (TN); Meclizine [INN:BAN]; Meclozina [INN-Spanish]; Meclozine (BAN); Meclozinum [INN-Latin]; Neo-istafene; Neo-suprimal; Neo-suprimel; Nevidoxine (TN); Postafen (TN); Sea-Legs; Ru-Vert-M; U. C. B. 5062; U.C.B. 5062; (+-)-Meclizine; 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine

Indication

Disease Entry	ICD 11	Status	REF
Dizziness	MB48	Approved	[1]
Meniere disease	AB31.0	Approved	[2]

Therapeutic Class

Antiallergic Agents

Cross-matching ID

PubChem CID: 4034
ChEBI ID: CHEBI:6709
CAS Number: CAS 569-65-3
TTD Drug ID: DMS7T13
VARIDT Drug ID: DR00977
INTEDE Drug ID: DR1006
ACDINA Drug ID: D00387

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Orphan nuclear receptor NR1I3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(5BETA)-PREGNANE-3,20-DIONE	DMVQ6RN	Discovery agent	N.A.	Investigative	[8]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[9]
TCPOBOP	DMKVF5Q	Discovery agent	N.A.	Investigative	[10]
androstenol	DM7RXQ6	Discovery agent	N.A.	Investigative	[11]
androstanol	DMPXF5I	Discovery agent	N.A.	Investigative	[11]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[13]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[17]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[18]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[19]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[20]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[21]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[25]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[27]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[28]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[29]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[30]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[33]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
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Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[5]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[6]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[6]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[58]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[56]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[6]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
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Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[6]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[6]
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Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[6]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[6]
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Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Orphan nuclear receptor NR1I3 (NR1I3)	TTRANFM	NR1I3_HUMAN	Modulator	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)^{Main DME}	DECB0K3	CP2D6_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[5]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[7]
Galanin peptides (GAL)	OTB3VPTO	GALA_HUMAN	Gene/Protein Processing	[6]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Gene/Protein Processing	[6]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Gene/Protein Processing	[6]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Gene/Protein Processing	[6]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1)	OTERJ4VQ	SO2B1_HUMAN	Gene/Protein Processing	[5]

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