Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS7T13)

Drug Name
Meclizine Drug Info
Synonyms
Ancolan; Ancolon; Antivert; Bonadettes; Bonine; Calmonal; Chiclida; Diadril; Histamethine; Histamethizine; Histametizine; Histametizyn; Histametizyne; Itinerol; Marex; Meclicot; Meclozina; Meclozine; Meclozinum; Medivert; Monamine; Navicalm; Nevidoxine; Parachloramine; Peremesin; Postafene; Ravelon; Sabari; Siguran; Subari; Suprimal; Travelon; Veritab; Vomisseis; Vomissels; Dramamine II; Meclizine Hcl; UCB 170; UCB 5052; UCB 5062; Antivert (TN); Antivert/25; Antivert/50; Bonamine (TN); Bonine (TN); Meclizine [INN:BAN]; Meclozina [INN-Spanish]; Meclozine (BAN); Meclozinum [INN-Latin]; Neo-istafene; Neo-suprimal; Neo-suprimel; Nevidoxine (TN); Postafen (TN); Sea-Legs; Ru-Vert-M; U. C. B. 5062; U.C.B. 5062; (+-)-Meclizine; 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine
Indication
Disease Entry ICD 11 Status REF
Dizziness MB48 Approved [1]
Meniere disease AB31.0 Approved [2]
Therapeutic Class
Antiallergic Agents
Cross-matching ID
PubChem CID
4034
ChEBI ID
CHEMBL1623
CAS Number
CAS 569-65-3
TTD Drug ID
DMS7T13
VARIDT Drug ID
DR00977
INTEDE Drug ID
DR1006
ACDINA Drug ID
D00387

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Orphan nuclear receptor NR1I3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(5BETA)-PREGNANE-3,20-DIONE DMVQ6RN Discovery agent N.A. Investigative [7]
CITCO DM0N634 Discovery agent N.A. Investigative [8]
TCPOBOP DMKVF5Q Discovery agent N.A. Investigative [9]
androstenol DM7RXQ6 Discovery agent N.A. Investigative [10]
androstanol DMPXF5I Discovery agent N.A. Investigative [10]
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [13]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [14]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [15]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [16]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [17]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [18]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [19]
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Prednisone DM2HG4X Acute asthma CA23 Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [34]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [35]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Ethanol DMDRQZU Chronic pain MG30 Approved [5]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [6]
Selenium DM25CGV N. A. N. A. Approved [40]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Galanin peptides (GAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [47]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [48]
Testosterone DM7HUNW Hot flushes GA30 Approved [49]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Orphan nuclear receptor NR1I3 (NR1I3) TTRANFM NR1I3_HUMAN Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [5]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Gene/Protein Processing [6]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Gene/Protein Processing [6]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Gene/Protein Processing [5]

References

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2 Meclizine FDA Label
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33 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
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