Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSM2KE)

Drug Name
Nitrofurazone Drug Info
Synonyms
nitrofurazone; Nitrofural; Furacilin; 59-87-0; Furacin; Furacillin; Furacine; Aldomycin; Furaldon; Nifuzon; Actin-N; Furacycline; Furacoccid; Otofuran; Nitrofurazan; Monafuracin; Furaziline; Furacinetten; Babrocid; Nitrozone; Mastofuran; Furazone; Chemofuran; Mammex; Amifur; Alfucin; Furesol; Furazol W; 5-Nitro-2-furaldehyde semicarbazone; Monofuracin; Dermofural; Monafuracis; Furaseptyl; Furatsilin; Nitrofurol; Fuvacillin; Furametral; Biofuracina; Becafurazone; Nifucin; Ibiofural; Hemofuran; Furalone; Furacort; Eldezol; Vadrocid; Vabrocid; Furazyme
Indication
Disease Entry ICD 11 Status REF
Skin burns ME65.0 Approved [1]
Bacterial infection 1A00-1C4Z Discontinued in Phase 3 [2]
Cross-matching ID
PubChem CID
5447130
ChEBI ID
CHEBI:44368
CAS Number
CAS 59-87-0
TTD Drug ID
DMSM2KE
INTEDE Drug ID
DR1168

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [15]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [16]
TP-434 DM5A31S Intra-abdominal infection 1A40 Approved [17]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [15]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [18]
Sarecycline DMLZNIQ Acne vulgaris ED80 Approved [19]
ME1100 DM39PSZ Bacterial pneumonia CA40.0 Phase 1 [20]
TP-6076 DM5RIT8 Enterobacteriaceae infection MG50.C Phase 1 [21]
TP-271 DM3PJSE Pneumonia CA40 Phase 1 [22]
TP 6076 DMD0NA1 Multidrug resistant infection MG51 Phase 1 [21]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [30]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [31]
Propranolol DM79NTF Angina pectoris BA40 Approved [32]
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Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase B (nfsB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [7]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [33]
Clonazepam DMTO13J Absence epilepsy Approved [34]
CB1954 DMVP4YK Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [7]
Nitrobenzodiazepine DM254EW N. A. N. A. Investigative [33]
Misonidazole DMYB0HK N. A. N. A. Investigative [35]
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Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase A (nfsA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [8]
Loperamide DMOJZQ9 Diarrhea ME05.1 Approved [36]
HSDB-674 DMJG4WR N. A. N. A. Phase 1 [37]
CB1954 DMVP4YK Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [38]
Drug(s) Metabolized By NADPH-dependent oxidoreductase (nfrA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [5]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [5]
Drug(s) Metabolized By NADPH-dependent nitroreductase (nfrA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [9]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [9]
Drug(s) Metabolized By Nitroreductase (NTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metronidazole DMTIVEN Abscess Approved [11]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [11]
Metronidazole DMTIVEN Abscess Approved [11]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [11]
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [42]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [13]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [46]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [51]
Paclitaxel DMLB81S Breast carcinoma Approved [52]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [60]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [62]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [42]
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Drug(s) Affected By Transketolase (TKT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [63]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [67]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [71]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA) TTOVFH2 NOUNIPROTAC Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]
NADPH-dependent oxidoreductase (nfrA) DE82GV7 NRFA_STAA8 Substrate [5] , [6]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DE0QLUZ NFSB_ECOLI Substrate [7]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DEDPI65 NFSA_ECOLI Substrate [8]
NADPH-dependent nitroreductase (nfrA1) DE21PLI NFRA1_BACSU Substrate [9] , [10]
Nitroreductase (NTR) DEUW4J0 A0A376H6M5_ENTGA Substrate [11]
Nitroreductase (NTR) DE3U2Y6 A0A377KR04_ENTCA Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [12]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [13]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [13]
Transketolase (TKT) OTT5KPUB TKT_HUMAN Drug Response [14]

References

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