Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWMPRG)

Drug Name
Tetrodotoxin Drug Info
Synonyms
Maculotoxin; Spheroidine; TTX; Tarichatoxin; Tetradotoxin; Tetrodontoxin; Tetrodotoxine; Tetrodoxin; Fugu Toxin; Fugu poison; BJT 1; Babylonia japonica toxin 1; Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10adimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol; Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol; (1R,5R,6R,7R,9S,11R,12R,13S,14S)-14-(hydroxymethyl)-3-imino-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1(7,11).0(1,6)]tetradecane-5,9,12,13,14-pentol; (1r,5r,6r,9r,11s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-3-ene-5,9,12,13,14-pentol(non-preferred name); (4R-(4alpha,4aalpha,5alpha,7alpha,9alpha,10alpha,10abeta,11S*,12S*))-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d) pyrimidine-4,7,10,11,12-pentol
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
11174599
CAS Number
CAS 4368-28-9
TTD Drug ID
DMWMPRG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium channel unspecific (NaC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [8]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [9]
Zonisamide DM0DTF7 Alcohol dependence 6C40.2 Approved [10]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [11]
LIDOFLAZINE DMV23GL Angina pectoris BA40 Approved [12]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [13]
Levobupivacaine DM783CH Anaesthesia 9A78.6 Approved [14]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [15]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [16]
Butacaine DM584TM Pain MG30-MG3Z Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [8]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [18]
Fosphenytoin DMOX3LB Epilepsy 8A60-8A68 Approved [8]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [18]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [13]
Dyclonine DMU6OFP Pain MG30-MG3Z Approved [19]
Moricizine DMOMBJW Arrhythmia BC9Z Approved [20]
Ethotoin DMXWOCP Complex partial seizure 8A68.0 Approved [21]
Prilocaine DMI7DZ2 Pain MG30-MG3Z Approved [19]
Hexylcaine DMEADRK Anaesthesia 9A78.6 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Voltage-gated sodium channel (Nav)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lacosamide DMVM6QR Convulsion 8A68.Z Approved [3]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [3]
Cenobamate DM8KLU9 Complex partial seizure 8A68.0 Approved [22]
Evenamide DMWB94K Schizophrenia 6A20 Phase 2 [23]
Drug(s) Affected By Sodium channel protein type 9 subunit alpha (SCN9A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [32]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Corticoliberin (CRH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [34]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [34]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Haloperidol DM96SE0 Delirium Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Terbutaline DMD4381 Asthma CA23 Approved [37]
Clozapine DMFC71L Schizophrenia 6A20 Approved [34]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [50]
Paclitaxel DMLB81S Breast carcinoma Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [43]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Antagonist [2]
Voltage-gated sodium channel (Nav) TTIG65Q NOUNIPROTAC Inhibitor [3]
Voltage-gated sodium channel alpha Nav1.5 (SCN5A) TTZOVE0 SCN5A_HUMAN Blocker [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Corticoliberin (CRH) OT2MOC4T CRF_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]
Sodium channel protein type 9 subunit alpha (SCN9A) OTGSKLL8 SCN9A_HUMAN Gene/Protein Processing [7]

References

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2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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