Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYAMP5)

Drug Name

EHT-1864 Drug Info

Synonyms

EHT-0101; EHT-0206; EHT-101; EHT-206; Rac1 inhibitor (Alzheimer's disease/cancer),Exonhit

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Terminated	[1]

Cross-matching ID

PubChem CID: 9938202
ChEBI ID: CHEMBL3216441
CAS Number: CAS 754240-09-0
TTD Drug ID: DMYAMP5

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[3]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[11]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[12]
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Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[15]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[20]
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Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[28]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[33]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ras-related C3 botulinum toxin substrate 1 (RAC1)	TT2M9CG	RAC1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Gene/Protein Processing	[2]
kinase isozyme 1, mitochondrial (PDK1)	OTMABK9Z	PDK1_HUMAN	Gene/Protein Processing	[2]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Gene/Protein Processing	[2]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Post-Translational Modifications	[2]

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References

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