Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZK0FQ)

Drug Name

Oestradiol valerate and dienogest Drug Info

Synonyms

Dienogest; 65928-58-7; Dienogestrel; Dienogestum; Dienogestril; Dinagest; Natazia; Endometrion; Visanne; STS-557; STS 557; Dienogestum [Latin]; UNII-46M3EV8HHE; MJR-35; 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; BAY86-5258; BAY 86-5258; 46M3EV8HHE; CHEBI:70708; 17-alpha-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one; 2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile; 17-alpha-Cyanomethyl-17-beta-hydroxyestra-4,9(10)-diene-3-one; Natazia (TN)

Indication

Disease Entry	ICD 11	Status	REF
Contraception	QA21	Approved	[1]
Endometriosis	GA10	Approved	[2]

Cross-matching ID

PubChem CID: 68861
ChEBI ID: CHEBI:70708
CAS Number: CAS 65928-58-7
TTD Drug ID: DMZK0FQ
INTEDE Drug ID: DR0490

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[7]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[8]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[13]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[14]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[15]
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Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[21]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[18]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[25]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[38]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[39]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[43]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[48]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[52]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[4]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[52]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[61]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
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Drug(s) Affected By Follitropin subunit beta (FSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[64]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[66]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[67]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[68]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[69]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
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Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[72]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[75]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[62]
Alprazolam	DMC7XDN	Anxiety		Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[73]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[75]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[4]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[5]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Gene/Protein Processing	[6]
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Gene/Protein Processing	[6]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Protein Interaction/Cellular Processes	[5]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Gene/Protein Processing	[5]

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