Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZWQH3)

• Drug Name: [125I]epibatidine Drug Info
• Synonyms: CHEMBL6623; NLPRAJRHRHZCQQ-UHFFFAOYSA-N; 140111-52-0; [3H]EPIBATIDINE; SR-01000597620; [125I]EPIBATIDINE; AC1Q3PYA; AC1L1AYB; 208/210 Epibatidine; KBioSS_000603; KBioGR_000603; BSPBio_001263; (R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[221]heptane; [3H]epibatidine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1204
  ChEBI ID: CHEBI:91678
  TTD Drug ID: DMZWQH3

Molecule-Related Drug Atlas

Drug(s) Targeting Neuronal acetylcholine receptor alpha-7 (CHRNA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[6]
ALCURONIUM	DM2U4XQ	Anaesthesia	9A78.6	Approved	[7]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[8]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[9]
EVP-6124	DMLQO7F	Alzheimer disease	8A20	Phase 3	[10]
GTS-21	DMEN5KA	Parkinson disease	8A00.0	Phase 2	[11]
JNJ-39393406	DMUOEKM	Depression	6A70-6A7Z	Phase 2	[12]
ABT-126	DM2OS51	Alzheimer disease	8A20	Phase 2	[13]
TC-6987	DMNFP21	Asthma	CA23	Phase 2	[14]
AQW-051	DMD2RFO	Alzheimer disease	8A20	Phase 2	[15]

Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[16]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[16]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[16]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[16]
Levallorphan	DMCOLUP	Narcotic depression	6A7Z	Approved	[17]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[16]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[17]
Pipecuronium	DM5F84A	Spasm	MB47.3	Approved	[17]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[18]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[19]

Drug(s) Targeting Muscarinic acetylcholine receptor M5 (CHRM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Promazine	DMZAL7W	Acute intermittent hepatic porphyria	5C58.11	Approved	[20]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[21]
Pilocarpine	DMV9ADG	Glaucoma/ocular hypertension	9C61	Approved	[22]
Anisodine	DMNOSWU	Central and peripheral nervous disease	8A04-8E7Z	Approved	[23]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[24]
Propiverine	DMUWBIJ	Urinary incontinence	MF50.2	Approved	[25]
Umeclidinium	DM4E8O9	Chronic obstructive pulmonary disease	CA22	Approved	[26]
Cimetropium bromide	DMZHPNE	Gastric motility disorder	DA21	Approved	[27]
Butylscopolamine	DMZKXB7	Dysmenorrhea	GA34.3	Approved	[28]
Trospium	DMX6RTG	Overactive bladder	GC50.0	Approved	[29]

Drug(s) Targeting Neuronal acetylcholine receptor beta-2 (CHRNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[30]
TC-5214	DM8AM60	Palmar hyperhidrosis	EE00.00	Phase 2	[31]
SUVN-911	DMLPBVF	Major depressive disorder	6A70.3	Phase 1	[32]
AZD-9684	DMHA5ME	Thrombosis	DB61-GB90	Discontinued in Phase 2	[33]
ABT-594	DMGMBCW	N. A.	N. A.	Discontinued in Phase 2	[34]
ABT-418	DMNP72I	Alzheimer disease	8A20	Discontinued in Phase 2	[35]
HOMOEPIBATIDINE	DMHP9WV	N. A.	N. A.	Terminated	[30]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[36]
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol	DMDUGZS	Discovery agent	N.A.	Investigative	[37]
(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol	DMDUI8R	Discovery agent	N.A.	Investigative	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Agonist	[2]
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Agonist	[3]
Neuronal acetylcholine receptor alpha-7 (CHRNA7)	TTLA931	ACHA7_HUMAN	Agonist	[4]
Neuronal acetylcholine receptor beta-2 (CHRNB2)	TT5KPZR	ACHB2_HUMAN	Agonist	[5]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 463).
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• [32] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [33] Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51.
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• [35] Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44.
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