Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2YGNW)

• Drug Name: Dactinomycin Drug Info
• Synonyms: Cosmegen; Dactinomicina; Dactinomycine; Dactinomycinum; Meractinomycin; ACT D; ACTINOMYCIN D AMP; Actactinomycin A IV; Actinomycin A IV; Actinomycin Aiv; Actinomycin I; Actinomycin IV; Actinomycin cl; Actinomycin x i; Antibiotic from Streptomyces parvullus; Chounghwamycin B; D Actinomycin; Dactinomycin D; Dactinomyein d; Dilactone actin omycindioic D acid; Dilactone actinomycin D acid; Dilactone actinomycindioic D acid; Lyovac cosmegen; Oncostatin K; Actinomycin 11 cosmegen; Actinomycin 7; Actinomycin C1; Actinomycin I1; Actinomycin X 1; Actinomycin X1; HBF 386; HBF 386 meractinomycin; X 97; AD (VAN); Actinomycin C (sub1); Actinomycin C(sub1); Actinomycin D (JP15); Actinomycin D, sodium deoxyribonucleic acid complex; Actinomycin I (sub1); Actinomycin I(sub 1); Actinomycin I(sub1); Actinomycin-IV; Actinomycindioic D acid, dilactone; Acto-D; COSMEGEN (TN); Dactinomicina [INN-Spanish]; Dactinomycin (USP); Dactinomycin [USAN:BAN]; Dactinomycine [INN-French]; Dactinomycinum [INN-Latin]; NP-005932; Actinomycin D deriv. of 3H-phenoxaocardazine; GNF-PF-1977; Actinomycin-[threo-val-pro-sar-meval]; Actinomyein-theo-val-pro-sar-meval; Actinomycin-(threo-val-pro-sar-meval); O)-(1-oxo-1,2-ethanediyl)]bis(N-methyl)L-valine; PXZ-THR-DVA-PRO-SAR-MVA-THR-DVA-PRO-SAR-MVA; DVA-DPR-SAR-MVA-(c1)DTH-PXZ-(c11)DTH-DVA-DPR-SAR-MVA; 1H-Pyrrolo(2,1-1)-(1,4,7,10,13)oxatetraazacyclohexadecine; 4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

Indication

Disease Entry	ICD 11	Status	REF
Adult kidney Wilms tumor		Approved	[1]
Advanced cancer	2A00-2F9Z	Approved	[1]
Beckwith-Wiedemann syndrome		Approved	[1]
Childhood kidney Wilms tumor		Approved	[1]
Gestational trophoblastic neoplasia	2F33-2F76	Approved	[1]
Hamartoma		Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Wilms tumor		Approved	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 457193
  ChEBI ID: CHEMBL1554
  CAS Number: CAS 50-76-0
  TTD Drug ID: DM2YGNW
  VARIDT Drug ID: DR01203
  ACDINA Drug ID: D00983

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[15]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[16]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[17]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[18]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[19]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[20]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[21]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[22]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[23]

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[30]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[31]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[32]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[33]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[37]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[45]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[47]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[48]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[49]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[50]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[51]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[52]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[53]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[54]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[55]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[56]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[57]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[55]

Drug(s) Affected By Dihydropyrimidinase-related protein 4 (DPYSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Integral membrane protein GPR137B (GPR137B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[71]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[72]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[75]
Abciximab	DMJO6GV	Acute disease		Approved	[76]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[76]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[76]

Drug(s) Affected By Ras-related protein R-Ras (RRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[91]

Drug(s) Affected By Stomatin (STOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[101]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[110]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[111]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[105]

Drug(s) Affected By Galectin-7 (LGALS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[119]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Large ribosomal subunit protein eL34 (RPL34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[128]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]

Drug(s) Affected By Epithelial membrane protein 3 (EMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[137]

Drug(s) Affected By Protein ripply3 (RIPPLY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Endonuclease III-like protein 1 (NTHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By Kinesin-like protein KIF1A (KIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[148]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[150]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[97]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[151]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Bortezomib	DMNO38U	Leukemia		Approved	[154]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]

Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]

Drug(s) Affected By Filamin-C (FLNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]

Drug(s) Affected By Immediate early response gene 5 protein (IER5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[71]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[101]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]

Drug(s) Affected By All-trans-retinol 13,14-reductase (RETSAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]

Drug(s) Affected By Interleukin-27 receptor subunit alpha (IL27RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]

Drug(s) Affected By Neuropilin and tolloid-like protein 2 (NETO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Bortezomib	DMNO38U	Leukemia		Approved	[154]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]

Drug(s) Affected By Mitochondria-eating protein (SPATA18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Indomethacin	DMSC4A7	Bursitis		Approved	[168]

Drug(s) Affected By Phospholipase ABHD3 (ABHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Homer protein homolog 3 (HOMER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[173]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By BSD domain-containing protein 1 (BSDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Bortezomib	DMNO38U	Leukemia		Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[145]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[145]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Stathmin-3 (STMN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]

Drug(s) Affected By Endothelial protein C receptor (PROCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[140]

Drug(s) Affected By Fatty acid desaturase 3 (FADS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[154]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Protein O-mannosyl-transferase 1 (POMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By Tumor protein p53-inducible protein 11 (TP53I11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[182]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[153]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[183]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[198]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[201]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[203]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[204]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[204]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[205]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[209]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[210]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[214]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[110]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase ROS (ROS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[221]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[222]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[224]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[225]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[229]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[227]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[232]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[235]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[238]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[239]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[110]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[245]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[248]

Drug(s) Affected By rRNA 2'-O-methyltransferase fibrillarin (FBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[249]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[144]

Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB1 (POLR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Deferasirox	DM6ETS0	Beta thalassemia	3A50.2	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[154]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[257]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[258]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[259]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[113]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[137]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[261]
Indomethacin	DMSC4A7	Bursitis		Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[264]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[267]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[272]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[273]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[204]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Selenium	DM25CGV	N. A.	N. A.	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[281]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[282]

Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[283]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[284]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[286]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[287]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[288]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[289]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[286]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[290]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[267]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[102]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[91]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[293]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[295]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[295]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[295]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[295]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[297]

Drug(s) Affected By Hyaluronidase-1 (HYAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[298]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[298]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[147]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[288]

Drug(s) Affected By Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[300]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[301]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[4]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[5]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[7]
All-trans-retinol 13,14-reductase (RETSAT)	OTC3AOPX	RETST_HUMAN	Gene/Protein Processing	[7]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Drug Response	[8]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[9]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[10]
BSD domain-containing protein 1 (BSDC1)	OT853CP9	BSDC1_HUMAN	Gene/Protein Processing	[7]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Gene/Protein Processing	[11]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Gene/Protein Processing	[7]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[12]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	OTPYQX3K	C1QBP_HUMAN	Drug Response	[13]

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