Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEDJN4)

DTT Name	Low-affinity nerve growth factor receptor (NGFR) DTT Info
Gene Name	NGFR

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cenegermin	DM8Y2RU	Neurotrophic keratitis	9A74	Approved	[1]
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3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulranumab	DMK38MV	Arthralgia	ME82	Phase 3	[2]
SPI-205	DMHC2AW	Parkinson disease	8A00.0	Phase 2	[3]
LM11A-31	DM095HQ	Alzheimer disease	8A20	Phase 1/2	[4]
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4 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Org-2766	DMVRA8N	Cognitive impairment	6D71	Discontinued in Phase 3	[5]
BU-4514N	DMJDMTK	Alzheimer disease	8A20	Terminated	[6]
CEP-427	DMTI10C	Alzheimer disease	8A20	Terminated	[2]
ReN-1820	DMWIAUK	Cystitis	GC00	Terminated	[7]
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6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALD-901	DMAYGK9	Pain	MG30-MG3Z	Investigative	[2]
Axogenesis Factor-1	DMT5P8O	Cerebrovascular ischaemia	8B1Z	Investigative	[2]
CRB-0022	DMPWZOK	Pain	MG30-MG3Z	Investigative	[2]
Nerve growth factor conjugated RAP peptide	DM3AW8X	Neurodegenerative disorder	8A20-8A23	Investigative	[2]
TDI-0033	DMQ7VDM	Motor neurone disease	8B60	Investigative	[2]
TDI-0059	DMSI9QM	Motor neurone disease	8B60	Investigative	[2]
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⏷ Show the Full List of 6 Investigative Drug(s)

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888).
3	AIT-082 NeoTherapeutics Inc. IDrugs. 1998 Oct;1(6):694-9.
4	Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.Neurobiol Aging.2013 Aug;34(8):2052-63.
5	Effects of the ACTH4-9 analog Org2766 on brain plasticity: modulation of excitatory neurotransmission. Psychoneuroendocrinology. 1992 Aug;17(4):315-25.
6	A new neuritogenetic compound BU-4514N produced by Microtetraspora sp. J Antibiot (Tokyo). 1993 Jun;46(6):875-83.
7	Phosphorylation of Extracellular Signal-Regulated Kinases (pERK1/2) in Bladder Afferent Pathways with Cyclophosphamide (CYP)-Induced Cystitis. Neuroscience. 2009 November 10; 163(4): 1353-1362.