Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTS6RZT)

• DTT Name: Histone-lysine N-methyltransferase EHMT2 (EHMT2) DTT Info
• Gene Name: EHMT2

Molecule-Related Drug & Molecule List

3 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A-366	DM1H45U	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
BIX-01294	DM5CBNY	Breast cancer	2C60-2C65	Preclinical	[2]
MS012	DM5AMFV	Inflammation	1A00-CA43.1	Preclinical	[3]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BRD9539	DMFAVB5	Discovery agent	N.A.	Investigative	[4]
UNC0321	DMCVU1T	Discovery agent	N.A.	Investigative	[5]
UNC0638	DM4A1KJ	Discovery agent	N.A.	Investigative	[6]
UNC0642	DM7Y1SO	Discovery agent	N.A.	Investigative	[7]

References

• [1] Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9.
• [2] Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81.
• [3] Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
• [4] A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
• [5] Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.
• [6] A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74.
• [7] Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42.