Details of Disease

General Information of Disease (ID: DIS08UKE)

• Disease Name: Postpartum depression
• Synonyms: post Natal depression; depression, post-partum; post-partum depression; depression, post-Natal; post-Natal depression; post partum depression; depression, postnatal; postpartum depression; depressive episode with postpartum onset; maternity blues; major depressive episode with peripartum onset; postnatal depression
• Disease Class: 6E20-6E8Z: Mental/behavioural/neurodevelopmental disorder
• Definition: A type of clinical depression that occurs after childbirth.
• Disease Hierarchy:
  DIS3XJ69: Depression
  DIS08UKE: Postpartum depression
• ICD Code:
  ICD-11: ICD-11: 6E20.0
  Expand ICD-11: '6E20.0
• Disease Identifiers:
  MONDO ID: MONDO_0005929
  MESH ID: D019052
  UMLS CUI: C0221074
  MedGen ID: 66359
  SNOMED CT ID: 58703003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Allopregnanolone	DMNLHAC	approved	Small molecular drug	[1]
Ganaxolone	DMXJMKF	Approved	Small molecular drug	[2]
Zuranolone	DMGR98T	Approved	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
OPRM1	TTKWM86	Limited	Biomarker	[4]
SLC6A4	TT3ROYC	Limited	Biomarker	[5]
GALR1	TTX3HNZ	Strong	Biomarker	[6]
HPD	TT8DSFC	Strong	Biomarker	[7]
HTR1A	TTSQIFT	Strong	Biomarker	[8]
SERPINA6	TTJL8VG	Strong	Genetic Variation	[9]
TPO	TT52XDZ	Strong	Biomarker	[10]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PER2	OTU2B1DJ	Limited	Biomarker	[11]
ARID4B	OTYLPILE	Strong	Biomarker	[12]
ATP5F1A	OT3FZDLX	Strong	Biomarker	[13]
CREB3L1	OT2JHIHM	Strong	Biomarker	[14]
EGR3	OTGPJIRA	Strong	Biomarker	[15]
HP1BP3	OTTJ5LX2	Strong	Posttranslational Modification	[16]
MARCHF11	OTODNSYN	Strong	Biomarker	[17]
MPI	OTBH6ZK1	Strong	Biomarker	[18]
SAGE1	OT4H6FFA	Strong	Biomarker	[19]
TTC9B	OTHBKTIU	Strong	Posttranslational Modification	[16]

References

• [1] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217369
• [4] OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.Psychoneuroendocrinology. 2011 Oct;36(9):1303-11. doi: 10.1016/j.psyneuen.2011.03.002. Epub 2011 Apr 3.
• [5] Gene-environment interaction in postpartum depression: a Chinese clinical study.J Affect Disord. 2014 Aug;165:208-12. doi: 10.1016/j.jad.2014.04.049. Epub 2014 Apr 30.
• [6] Inhibition of GALR1 in PFC Alleviates Depressive-Like Behaviors in Postpartum Depression Rat Model by Upregulating CREB-BNDF and 5-HT Levels.Front Psychiatry. 2018 Nov 14;9:588. doi: 10.3389/fpsyt.2018.00588. eCollection 2018.
• [7] Prevalence, symptomatology, risk factors and healthcare services utilization regarding paternal depression in Germany: study protocol of a controlled cross-sectional epidemiological study.BMC Psychiatry. 2019 Sep 18;19(1):289. doi: 10.1186/s12888-019-2280-7.
• [8] Role of maternal 5-HT(1A) receptor in programming offspring emotional and physical development.Genes Brain Behav. 2010 Nov;9(8):877-85. doi: 10.1111/j.1601-183X.2010.00625.x.
• [9] Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study.Psychoneuroendocrinology. 2019 May;103:296-305. doi: 10.1016/j.psyneuen.2019.02.002. Epub 2019 Feb 7.
• [10] Thyroid peroxidase antibodies during early gestation and the subsequent risk of first-onset postpartum depression: A prospective cohort study.J Affect Disord. 2018 Jan 1;225:399-403. doi: 10.1016/j.jad.2017.08.058. Epub 2017 Aug 23.
• [11] The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptoms.J Affect Disord. 2012 Feb;136(3):1192-7. doi: 10.1016/j.jad.2011.11.042. Epub 2011 Dec 29.
• [12] Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.Brain Behav. 2017 Sep 14;7(10):e00828. doi: 10.1002/brb3.828. eCollection 2017 Oct.
• [13] Rationale, design, and baseline data for the Healthy Mom II Trial: A randomized trial examining the efficacy of exercise and wellness interventions for the prevention of postpartum depression.Contemp Clin Trials. 2018 Jul;70:15-23. doi: 10.1016/j.cct.2018.05.002. Epub 2018 May 7.
• [14] Poor sleep quality increases symptoms of depression and anxiety in postpartum women.J Behav Med. 2018 Oct;41(5):703-710. doi: 10.1007/s10865-018-9950-7. Epub 2018 Jul 20.
• [15] A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression.J Affect Disord. 2019 Jun 15;253:51-62. doi: 10.1016/j.jad.2019.04.059. Epub 2019 Apr 9.
• [16] DNA methylation biomarkers prospectively predict both antenatal and postpartum depression.Psychiatry Res. 2020 Mar;285:112711. doi: 10.1016/j.psychres.2019.112711. Epub 2019 Nov 27.
• [17] Postpartum depression among women in Nagoya indirectly exposed to the Great East Japan Earthquake.Sci Rep. 2018 Aug 2;8(1):11624. doi: 10.1038/s41598-018-30065-w.
• [18] Promoting the well-being of mothers with multidisciplinary psychosocial interventions in the perinatal period.J Affect Disord. 2019 Mar 1;246:148-156. doi: 10.1016/j.jad.2018.12.028. Epub 2018 Dec 18.
• [19] SAGE-217, A Novel GABA(A) Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.Clin Pharmacokinet. 2020 Jan;59(1):111-120. doi: 10.1007/s40262-019-00801-0.