Details of Disease

General Information of Disease (ID: DIS1UU1B)

• Disease Name: Methamphetamine dependence
• Disease Class: 6C46: Stimulants use disorder
• Definition: A drug dependence that is a psychological dependency on the regular use of methamphetamine.
• Disease Hierarchy:
  DIS9IXRC: Drug dependence
  DIS1UU1B: Methamphetamine dependence
• ICD Code:
  ICD-11: ICD-11: 6C46.2
  ICD-10: ICD-10: F15.2
• Disease Identifiers:
  MONDO ID: MONDO_0005419
  UMLS CUI: C1533217
  MedGen ID: 735816
  HPO ID: HP:0033519
  SNOMED CT ID: 426873000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Armodafinil	DMGB035	Approved	Small molecular drug	[1]
Atomoxetine	DM5L6HI	Approved	Small molecular drug	[2]
Ibudilast	DM4LSPN	Approved	Small molecular drug	[3]
Methamphetamine	DMPM4SK	Approved	Small molecular drug	[4]
Modafinil	DMYILBE	Approved	Small molecular drug	[5]
Quetiapine	DM1N62C	Approved	Small molecular drug	[6]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
METH-mab	DMJHOKN	Phase 1	Monoclonal antibody	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CSNK1E	TTA8PLI	Strong	Genetic Variation	[8]
GRIA3	TT82EZV	Strong	Genetic Variation	[9]
MGAT1	TTYJRN5	Strong	Genetic Variation	[10]
NPY1R	TTRK9JT	Strong	Genetic Variation	[11]
PROKR2	TTM67AX	Strong	Biomarker	[12]
SLC6A9	TTHJTF7	Strong	Genetic Variation	[10]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
FAAH	DEUM1EX	Limited	Genetic Variation	[13]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GABBR1	OTU5A52J	Strong	Biomarker	[14]
NAT8L	OTA96AVN	Strong	Genetic Variation	[15]
PROK2	OT70IFEZ	Strong	Biomarker	[16]
TSNAX	OTZ9SGWB	Strong	Biomarker	[16]

References

• [1] Armodafinil FDA Label
• [2] Atomoxetine FDA Label
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Methamphetamine FDA Label
• [5] Modafinil FDA Label
• [6] Quetiapine FDA Label
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036212)
• [8] Association study between casein kinase 1 epsilon gene and methamphetamine dependence.Ann N Y Acad Sci. 2008 Oct;1139:43-8. doi: 10.1196/annals.1432.025.
• [9] Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis.J Psychopharmacol. 2018 Mar;32(3):309-315. doi: 10.1177/0269881117750153. Epub 2018 Jan 17.
• [10] The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):54-8. doi: 10.1002/ajmg.b.30565.
• [11] Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Psychiatry Clin Neurosci. 2009 Jun;63(3):417-22. doi: 10.1111/j.1440-1819.2009.01961.x.
• [12] PROKR2 is associated with methamphetamine dependence in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1033-6. doi: 10.1016/j.pnpbp.2010.05.018. Epub 2010 May 24.
• [13] FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence.Ann Hum Genet. 2020 May;84(3):259-270. doi: 10.1111/ahg.12368. Epub 2019 Dec 2.
• [14] Variants in GABBR1 Gene Are Associated with Methamphetamine Dependence and Two Years' Relapse after Drug Rehabilitation.J Neuroimmune Pharmacol. 2018 Dec;13(4):523-531. doi: 10.1007/s11481-018-9802-9. Epub 2018 Aug 24.
• [15] Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate.Behav Brain Res. 2018 Feb 26;339:207-214. doi: 10.1016/j.bbr.2017.11.040. Epub 2017 Dec 2.
• [16] Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population.Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1618-22. doi: 10.1016/j.pnpbp.2011.06.001. Epub 2011 Jun 13.