Details of Disease

Disease Name

Urinary system neoplasm

urinary tract tumour; tumour of the urinary system; tumor of renal system; tumour of urinary tract; neoplasm of the urinary system; neoplasm of the urinary tract; urinary system tumor; renal system tumour; renal system neoplasm (disease); renal system neoplasm; tumour of urinary system; urinary tract tumor; tumour of the urinary tract; urinary system neoplasm; tumor of the urinary tract; tumour of renal system; tumor of the urinary system; urinary system tumour; renal system tumor; neoplasm of renal system; tumor of urinary system; urinary tract neoplasm; neoplasm of urinary system; neoplasm of urinary tract; tumor of urinary tract

Definition

A benign or malignant, primary or metastatic neoplasm involving the urinary system. --2003|Editor note: note the ONCOTREE class is more general than just bladder

Disease Hierarchy

DISTBY9Z: Tumour

DIS0HU8N: Urinary tract disease

DIS1VI2T: Urinary system neoplasm

Disease Identifiers

MONDO ID

MONDO_0021066

MESH ID

D014571

UMLS CUI

C0042076

MedGen ID

52949

HPO ID

HP:0010786

SNOMED CT ID

126879004

General Information of Disease (ID: DIS1VI2T)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Docetaxel	DMDI269	Approved	Small molecular drug	[1]
Mitomycin	DMH0ZJE	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATR	TT8ZYBQ	Strong	Biomarker	[3]
CCND1	TTFCJ7S	Strong	Biomarker	[4]
FHIT	TTMS54D	Strong	Biomarker	[3]
OGG1	TTRU01G	Strong	Biomarker	[5]
REG4	TTVZEHU	Strong	Altered Expression	[6]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SULT1A1	DEYWLRK	Strong	Biomarker	[7]
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References

1	Docetaxel FDA Label
2	Mitomycin FDA Label
3	Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells.Toxicol Lett. 2013 Jul 4;220(2):118-25. doi: 10.1016/j.toxlet.2013.04.007. Epub 2013 Apr 22.
4	Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16.Toxicol Lett. 2011 Jan 15;200(1-2):59-66. doi: 10.1016/j.toxlet.2010.10.015. Epub 2010 Oct 30.
5	Polymorphisms of human 8-oxoguanine DNA glycosylase 1 and 8-hydroxydeoxyguanosine increase susceptibility to arsenic methylation capacity-related urothelial carcinoma.Arch Toxicol. 2016 Aug;90(8):1917-27. doi: 10.1007/s00204-015-1590-x. Epub 2015 Sep 10.
6	Immunohistochemical analysis of Reg IV in urogenital organs: Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker.Oncol Rep. 2009 Jan;21(1):95-100.
7	Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma.Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2500-3. doi: 10.1158/1055-9965.EPI-07-0361.