Details of Disease

General Information of Disease (ID: DIS51FA4)

• Disease Name: Cough
• Disease Class: MD12: Cough
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DIS51FA4: Cough
• ICD Code:
  ICD-11: ICD-11: MD12
  ICD-10: ICD-10: R05
  Expand ICD-10: G89,R05,R52
  Expand ICD-9: 338,786.2,780
• Disease Identifiers:
  MedGen ID: 41325
  HPO ID: HP:0012735
  SNOMED CT ID: 263731006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 29 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ammonium chloride	DMPJCXG	Approved	Small molecular drug	[1]
Benzocaine	DMI18HW	Approved	Small molecular drug	[2]
Benzonatate	DM9U4FO	Approved	Small molecular drug	[3]
Bromodiphenhydramine	DMNDJT5	Approved	Small molecular drug	[4]
Carbetapentane	DMJBZ8N	Approved	Small molecular drug	[5]
Chlophedianol	DMXGJEI	Approved	Small molecular drug	[6]
Cloperastine	DMBKJL1	Approved	Small molecular drug	[5]
Codeine	DMJX6ZG	Approved	Small molecular drug	[7]
Cyclizine	DM9G7BS	Approved	Small molecular drug	[8]
Dextromethorphan	DMUDJZM	Approved	Small molecular drug	[9]
Epoprostenol	DMUTYR2	Approved	Small molecular drug	[10]
Flutropium bromide	DMU54C3	Approved	Small molecular drug	[5]
Glycine	DMIOZ29	Approved	Small molecular drug	[11]
Homatropine Methylbromide	DMGBPSH	Approved	Small molecular drug	[12]
Hydrocodone	DMQ2JO5	Approved	Small molecular drug	[13]
Hydromorphone	DMHP21E	Approved	Small molecular drug	[14]
Levodropropizine	DMJP5YF	Approved	Small molecular drug	[5]
Levopropoxyphene Napsylate Anhydrous	DMECB4H	Approved	Small molecular drug	[5]
Noscapine (narcotine)	DMCJLPB	Approved	Small molecular drug	[5]
Oxtriphylline	DMLHSE3	Approved	Small molecular drug	[15]
Pheniramine	DMCH7RU	Approved	Small molecular drug	[16]
Phenylephrine	DMZHUO5	Approved	Small molecular drug	[17]
Potassium iodide	DMPO7S1	Approved	Small molecular drug	[18]
Rorifone	DMHF1ID	Approved	Small molecular drug	[5]
Scopolamine	DMOM8AL	Approved	Small molecular drug	[19]
Terpin hydrate	DME0E5T	Approved	Small molecular drug	[5]
TRN-124	DMVAPTC	Approved	NA	[20]
Zipeprol	DM87ZCN	Approved	Small molecular drug	[5]
Dihydrocodeine	DMB0FWL	Phase 4	Small molecular drug	[21]

This Disease is Treated as An Indication in 9 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Gefapixant	DM4GWL7	Phase 3	NA	[22]
BAY-1902607	DMYSQMW	Phase 2	NA	[22]
GSK2339345	DMRA3T2	Phase 2	NA	[23]
PDC-748	DMW02ZH	Phase 2	NA	[24]
RG6341	DMPVJD1	Phase 2	NA	[25]
SCH-900978	DMPBKUZ	Phase 2	NA	[26]
BAY 1902607	DMFA4CK	Phase 1/2	Small molecular drug	[27]
BAY 1817080	DMF9ALP	Phase 1	Small molecular drug	[28]
Chlorcyclizine	DM3L52Q	Phase 1	Small molecular drug	[29]

This Disease is Treated as An Indication in 5 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clobutinol	DMJAJSJ	Withdrawn from market	Small molecular drug	[5]
Phenylpropanolamine	DMTFK3O	Withdrawn from market	Small molecular drug	[30]
MOGUISTEINE	DMR22NI	Discontinued in Preregistration	Small molecular drug	[31]
DF-1012	DMPUUJ8	Discontinued in Phase 2	NA	[32]
TRK-851	DMZ5RA7	Discontinued in Phase 1	NA	[33]

This Disease is Treated as An Indication in 10 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AG-NDT802	DMW17KP	Investigative	NA	[34]
CP1	DMGGENG	Investigative	NA	[34]
CRTX-067	DMT9WQU	Investigative	NA	[34]
CRTX-072	DMVM2D4	Investigative	NA	[34]
CRTX-074	DMEWN0B	Investigative	NA	[34]
JNJ-17203212	DMDUWBF	Investigative	Small molecular drug	[35]
LPCN-1087	DM5DIME	Investigative	NA	[34]
LPCN-1090	DMSE1ZZ	Investigative	NA	[34]
SODIUM CITRATE	DMHPD2Y	Investigative	Small molecular drug	[36]
ZP-004	DMN3UZF	Investigative	NA	[34]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Ammonium chloride FDA Label
• [2] Benzocaine. 2021 Oct 18. Drugs and Lactation Database (LactMed?) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006C.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7611).
• [4] Bromodiphenhydramine FDA Label
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [6] Chlophedianol FDA Label
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1673).
• [8] Cyclizine FDA Label
• [9] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6953).
• [10] Epoprostenol FDA Label
• [11] Glycine FDA Label
• [12] Homatropine Methylbromide FDA Label
• [13] Hydrocodone FDA Label
• [14] Hydromorphone FDA Label
• [15] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 086742.
• [16] Pheniramine FDA Label
• [17] Isoproterenol FDA Label
• [18] Potassium iodide FDA Label
• [19] Scopolamine FDA Label
• [20] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [21] Caffeine FDA Label
• [22] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [23] ClinicalTrials.gov (NCT01899768) GSK2339345 Hypertussive Challenge Study. U.S. National Institutes of Health.
• [24] ClinicalTrials.gov (NCT00547846) A Phase II Clinical Study of PDC-748 in Patients With Acute Cough. U.S. National Institutes of Health.
• [25] Clinical pipeline report, company report or official report of Roche
• [26] Clinical pipeline report, company report or official report of OPKO Health Inc.
• [27] ClinicalTrials.gov (NCT03535168) Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients. U.S. National Institutes of Health.
• [28] ClinicalTrials.gov (NCT04471337) Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function. U.S. National Institutes of Health.
• [29] Experimental and clinical evaluation of chlorcyclizine as an antitussive. Arzneimittelforschung. 1957 May;7(5):301-4.
• [30] Phenylpropanolamine FDA Label
• [31] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003316)
• [32] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005665)
• [33] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015232)
• [34] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [35] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4228).
• [36] SODIUM CITRATE FDA Label