Details of Disease

General Information of Disease (ID: DISAVKAH)

Disease Name	Oral candidiasis
Synonyms	thrush; thrush, oral; mouth candidiasis; oral moniliasis; candidiasis of mouth
Disease Class	1F23: Candidosis
Definition	Infection of the mucosal lining of the mouth with the fungus Candida albicans.
Disease Hierarchy	DISX82BI: Mouth disorder DISIRYMU: Candidiasis DISAVKAH: Oral candidiasis
ICD Code	ICD-11 ICD-11: 1F23.0 ICD-10 ICD-10: B37.0 Expand ICD-11 '1F23.0 Expand ICD-10 'B37.0
Disease Identifiers	MONDO ID MONDO_0005886 MESH ID D002180 UMLS CUI C0006849 MedGen ID 14300 SNOMED CT ID 79740000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Clotrimazole	DMMFCIH	Approved	Small molecular drug	[2]
Fluconazole	DMOWZ6B	Approved	Small molecular drug	[3]
Ketoconazole	DMPZI3Q	Approved	Small molecular drug	[4]
Nystatin	DM63QS9	Approved	Small molecular drug	[5]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PAC-113	DM0SCDF	Phase 2	NA	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APCS	TTB7VAT	moderate	Biomarker	[7]
LTF	TTSZDQU	moderate	Therapeutic	[8]
ADH1A	TT5AHZ0	Strong	Altered Expression	[9]
DEFB4A	TTIVY12	Strong	Biomarker	[10]
ELK3	TT5OJMV	Strong	Altered Expression	[11]
PLD1	TT3T17P	Strong	Biomarker	[12]
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⏷ Show the Full List of 6 DTT(s)

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PSAP	OTUOEKY7	Limited	Altered Expression	[11]
TRAF3IP2	OTLLZERL	Limited	Genetic Variation	[13]
SH2D1A	OTLU49I5	moderate	Biomarker	[7]
CDR2	OTD3ZJST	Strong	Biomarker	[9]
ELK4	OTVSSEOE	Strong	Biomarker	[14]
HTN3	OTEUXA81	Strong	Altered Expression	[15]
IGFALS	OTTWCZYM	Strong	Altered Expression	[16]
IL12RB1	OTM1IJO2	Strong	Genetic Variation	[17]
LRRCC1	OTVEBJ1V	Strong	Altered Expression	[11]
PTPRH	OTDUHQGF	Strong	Biomarker	[14]
SCLT1	OT2ZSSP4	Strong	Biomarker	[14]
SEPTIN7	OTJI08YX	Strong	Biomarker	[18]
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⏷ Show the Full List of 12 DOT(s)

References

1	Amphotericin B FDA Label
2	Clotrimazole FDA Label
3	Fluconazole FDA Label
4	Ketoconazole FDA Label
5	Nystatin FDA Label
6	ClinicalTrials.gov (NCT00659971) Phase 2B Dose-Ranging Study of PAC113 Mouthrinse in HIV Seropositive Individuals With Oral Candidiasis. U.S. National Institutes of Health.
7	Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis.J Invest Dermatol. 2000 Apr;114(4):712-7. doi: 10.1046/j.1523-1747.2000.00935.x.
8	Therapeutic potential of iron chelators in diseases associated with iron mismanagement.J Pharm Pharmacol. 2006 May;58(5):575-84. doi: 10.1211/jpp.58.5.0001.
9	ADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS-I) patients.FEMS Yeast Res. 2011 Sep;11(6):494-8. doi: 10.1111/j.1567-1364.2011.00739.x. Epub 2011 Jun 16.
10	Dynamic changes of Th1/Th2/Th17 cytokines and human beta defensin 2 in HIV-infected patients with oral candidiasis during the first year of highly active anti-retroviral therapy.Arch Oral Biol. 2018 Aug;92:62-67. doi: 10.1016/j.archoralbio.2018.05.003. Epub 2018 May 3.
11	Genotyping of Candidaalbicans isolates from oropharyngeal candidiasis in head and neck cancer patients in Iran: Molecular epidemiology and SAP2 gene expression.J Mycol Med. 2019 Dec;29(4):310-316. doi: 10.1016/j.mycmed.2019.100896. Epub 2019 Sep 11.
12	Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium.APMIS. 2006 Dec;114(12):857-66. doi: 10.1111/j.1600-0463.2006.apm_479.x.
13	Chronic Mucocutaneous Candidiasis in an Adolescent Boy Due to a Novel Mutation in TRAF3IP2.J Clin Immunol. 2019 Aug;39(6):596-599. doi: 10.1007/s10875-019-00664-x. Epub 2019 Jul 10.
14	In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.Infect Immun. 1999 May;67(5):2482-90. doi: 10.1128/IAI.67.5.2482-2490.1999.
15	Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis.Protein Sci. 2020 Feb;29(2):480-493. doi: 10.1002/pro.3767. Epub 2019 Nov 20.
16	RT-PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients.Med Mycol. 2006 Mar;44(2):103-11. doi: 10.1080/13693780500086527.
17	Inherited IL-12R1 Deficiency in a Child With BCG Adenitis and Oral Candidiasis: A Case Report.Pediatrics. 2017 Nov;140(5):e20161668. doi: 10.1542/peds.2016-1668. Epub 2017 Oct 12.
18	Genotypes of Candida albicans isolated from healthy individuals and their distribution in patients with oral candidiasis.J Infect Chemother. 2013 Dec;19(6):1072-9. doi: 10.1007/s10156-013-0626-5. Epub 2013 Jun 12.