Details of Disease

General Information of Disease (ID: DISDYCHC)

Disease Name	Optic neuritis
Disease Class	9C40: Optic nerve disorder
Definition	Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.
Disease Hierarchy	DISB3X5A: Nervous system inflammation DISB52BH: Eye disorder DISWD40R: Disease DISSOQM8: Optic nerve disorder DISDYCHC: Optic neuritis
ICD Code	ICD-11 ICD-11: 9C40.1 ICD-10 ICD-10: H46 Expand ICD-11 '9C40.1 Expand ICD-10 'H46
Disease Identifiers	MONDO ID MONDO_0005885 MESH ID D009902 UMLS CUI C0029134 MedGen ID 18181 HPO ID HP:0100653 SNOMED CT ID 66760008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
RTL-342m	DM0PCVY	Investigative	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TPX2	TT0PHL4	Limited	Biomarker	[2]
NFKB2	TTKLNRV	Disputed	Biomarker	[2]
PMEL	TT8MK59	Disputed	Biomarker	[2]
AVPR2	TTK8R02	Strong	Biomarker	[3]
CAPN1	TT1WBIJ	Strong	Biomarker	[4]
HCRT	TTU5HJP	Strong	Altered Expression	[5]
LINGO1	TTZYQ80	Strong	Biomarker	[6]
MAG	TT9XFON	Strong	Biomarker	[7]
MBP	TT2RY5P	Strong	Biomarker	[8]
RTN4R	TTVRZUO	Strong	Biomarker	[6]
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⏷ Show the Full List of 10 DTT(s)

This Disease Is Related to 16 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CUX1	OTU1LCNJ	Limited	Biomarker	[2]
OAS3	OT6E5FYS	Limited	Biomarker	[2]
SND1	OTT734JN	Limited	Biomarker	[2]
ASCC2	OT3B204T	Disputed	Biomarker	[2]
SART3	OTC1AM7S	Disputed	Biomarker	[2]
CLDN11	OTNN6UTL	Strong	Biomarker	[9]
DPYSL5	OT6F9T6F	Strong	Biomarker	[10]
HLA-DRB5	OTUX5TWM	Strong	Biomarker	[11]
MARCHF11	OTODNSYN	Strong	Biomarker	[12]
MLC1	OTCNZLSP	Strong	Biomarker	[13]
NEFH	OTMSCW5I	Strong	Biomarker	[14]
PHLDA2	OTMV9DPP	Strong	Biomarker	[15]
PLXNA2	OTNNBJMQ	Strong	Biomarker	[16]
POU2F3	OTIOOJWD	Strong	Genetic Variation	[17]
RASD1	OT2BAJHK	Strong	Genetic Variation	[18]
RASL12	OTNAK9X4	Strong	Genetic Variation	[19]
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⏷ Show the Full List of 16 DOT(s)

References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders.Neurology. 2020 Jan 28;94(4):e407-e418. doi: 10.1212/WNL.0000000000008684. Epub 2019 Dec 3.
3	Detecting optic nerve lesions in clinically isolated syndrome and multiple sclerosis: double-inversion recovery magnetic resonance imaging in comparison with visually evoked potentials.J Neurol. 2019 Jan;266(1):148-156. doi: 10.1007/s00415-018-9114-2. Epub 2018 Nov 16.
4	Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis.J Neuropathol Exp Neurol. 2013 Aug;72(8):745-57. doi: 10.1097/NEN.0b013e31829c7370.
5	Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event.Int Ophthalmol. 2020 Jan;40(1):151-158. doi: 10.1007/s10792-019-01157-x. Epub 2019 Aug 20.
6	Nogo-A Antibodies for Progressive Multiple Sclerosis.CNS Drugs. 2017 Mar;31(3):187-198. doi: 10.1007/s40263-017-0407-2.
7	Clues to the immunopathogenesis of multiple sclerosis by investigating untreated patients during the very early stage of disease.Neurol Sci. 2001 Apr;22(2):145-9. doi: 10.1007/s100720170013.
8	PCR typing of two short tandem repeat (STR) structures upstreams of the human myelin basic protein (MBP) gene; the genetic susceptibility in multiple sclerosis and monosymptomatic idiopathic optic neuritis in Danes.Mult Scler. 1995 Nov;1(3):186-9. doi: 10.1177/135245859500100310.
9	Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve.Eur J Immunol. 2008 May;38(5):1452-64. doi: 10.1002/eji.200737164.
10	Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG.Ann Neurol. 2003 Jul;54(1):38-50. doi: 10.1002/ana.10587.
11	Distribution of HLA-Dw2 in optic neuritis and multiple sclerosis indicates heterogeneity.Acta Neurol Scand. 1996 Sep;94(3):161-6. doi: 10.1111/j.1600-0404.1996.tb07047.x.
12	Anatomical Wiring and Functional Networking Changes in the Visual System Following Optic Neuritis.JAMA Neurol. 2018 Mar 1;75(3):287-295. doi: 10.1001/jamaneurol.2017.3880.
13	Relation between Genetic markers and oligoclonal IgG in CSF in optic neuritis.J Neurol Sci. 1976 Jan;27(1):93-8. doi: 10.1016/0022-510x(76)90237-9.
14	Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis.Dis Markers. 2017;2017:5434310. doi: 10.1155/2017/5434310. Epub 2017 Sep 11.
15	Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode.Acta Ophthalmol. 2017 Sep;95(6):583-590. doi: 10.1111/aos.13257. Epub 2016 Oct 24.
16	Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis: Results from a clinical trial cohort.Mult Scler. 2019 Jan;25(1):55-62. doi: 10.1177/1352458517739136. Epub 2017 Nov 7.
17	PlA1/A2 polymorphism of the platelet glycoprotein receptor IIIA and risk of cranial ischemic complications in giant cell arteritis.Arthritis Rheum. 2007 Oct;56(10):3502-8. doi: 10.1002/art.22922.
18	Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.Sci Rep. 2019 Aug 12;9(1):11664. doi: 10.1038/s41598-019-48087-3.
19	The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review.J Autoimmun. 2014 Feb-Mar;48-49:134-42. doi: 10.1016/j.jaut.2014.01.022. Epub 2014 Feb 10.