Details of Disease

General Information of Disease (ID: DISKMQBM)

• Disease Name: Listeriosis
• Synonyms: Listeria monocytogenes infection; Listeria monocytogenes caused disease or disorder; infection by Listeria monocytogenes; Listeria infection; Listeria monocytogenes infectious disease; Listeria monocytogenes disease or disorder
• Definition: A bacterial infection caused by Listeria monocytogenes. It occurs in newborns, elderly, and immunocompromised patients. The bacteria are transmitted through ingestion of contaminated food. Clinical manifestations include fever, muscle pain, respiratory distress, nausea, diarrhea, neck stiffness, irritability, seizures, and lethargy.
• Disease Hierarchy:
  DISGFCIX: Vector-borne disease
  DIS8ZVFW: Primary bacterial infectious disease
  DISEM33Q: Infectious disease
  DISKMQBM: Listeriosis
• Disease Identifiers:
  MONDO ID: MONDO_0005828
  MESH ID: D008088
  UMLS CUI: C0023860
  MedGen ID: 9788
  Orphanet ID: 533
  SNOMED CT ID: 4241002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Doxycycline	DM7ICNU	Approved	Small molecular drug	[1]
Erythromycin	DM4K7GQ	Approved	Small molecular drug	[2]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[3]
Minocycline	DMVN5OH	Approved	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FAF1	TTSKL3G	Limited	Biomarker	[5]
SLC5A1	TT2UE56	moderate	Biomarker	[6]
EIF2AK1	TTRUJBV	Strong	Genetic Variation	[7]
GRIN1	TTLD29N	Strong	Biomarker	[8]
HSP90B1	TTFPKXQ	Strong	Biomarker	[9]
IL15	TTJFA35	Strong	Biomarker	[10]
ISG15	TTVOH3T	Strong	Biomarker	[11]
LIPE	TTLUQ8E	Strong	Genetic Variation	[12]
NOD2	TTYPUHA	Strong	Biomarker	[13]
PTP4A2	TT1MHKD	Strong	Biomarker	[14]
SENP1	TTW9HY5	Strong	Biomarker	[15]

This Disease Is Related to 14 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CYLD	OT37FKH0	moderate	Biomarker	[16]
ACTA1	OTOVGLPG	Strong	Biomarker	[17]
BAHD1	OT9YGK94	Strong	Biomarker	[18]
CARD8	OTXXZYWU	Strong	Biomarker	[19]
CASD1	OT1YB54Z	Strong	Biomarker	[20]
CLEC5A	OT19WV30	Strong	Biomarker	[21]
IFIT3	OTPGHZB9	Strong	Biomarker	[22]
LGI1	OTPS77HO	Strong	Biomarker	[23]
LGI2	OTFJ2ZSG	Strong	Biomarker	[24]
LXN	OTZQ2M6Y	Strong	Biomarker	[25]
NOP53	OTA2YKO6	Strong	Biomarker	[22]
OCRL	OTQ3L42N	Strong	Biomarker	[26]
SUMF2	OT37I8JL	Strong	Biomarker	[27]
TNIP3	OTSAE5UE	Strong	Biomarker	[28]

References

• [1] Doxycycline FDA Label
• [2] Erythromycin FDA Label
• [3] Antimicrobial Resistance of Listeria monocytogenes from Animal Foods to First- and Second-Line Drugs in the Treatment of Listeriosis from 2008 to 2021: A Systematic Review and Meta-Analysis. Can J Infect Dis Med Microbiol. 2022 Oct 7;2022:1351983.
• [4] Minocycline FDA Label
• [5] Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection.PLoS Pathog. 2019 Aug 14;15(8):e1008004. doi: 10.1371/journal.ppat.1008004. eCollection 2019 Aug.
• [6] SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice.Cell Physiol Biochem. 2017;42(4):1358-1365. doi: 10.1159/000479197. Epub 2017 Jul 14.
• [7] The eIF2 Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking.Infect Immun. 2018 Feb 20;86(3):e00707-17. doi: 10.1128/IAI.00707-17. Print 2018 Mar.
• [8] Immunohistochemical evaluation of natural cases of encephalitic listeriosis in sheep.Biotech Histochem. 2019 Jul;94(5):341-347. doi: 10.1080/10520295.2019.1571225. Epub 2019 Feb 7.
• [9] Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins.EMBO Rep. 2017 Feb;18(2):303-318. doi: 10.15252/embr.201642833. Epub 2016 Dec 30.
• [10] Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats.Infect Immun. 1998 Dec;66(12):5677-83. doi: 10.1128/IAI.66.12.5677-5683.1998.
• [11] The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection.Nat Commun. 2019 Nov 26;10(1):5383. doi: 10.1038/s41467-019-13393-x.
• [12] A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates.Nat Commun. 2019 Sep 30;10(1):4283. doi: 10.1038/s41467-019-12072-1.
• [13] E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.Nat Commun. 2017 Jun 28;8:15865. doi: 10.1038/ncomms15865.
• [14] PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.Front Immunol. 2018 Nov 13;9:2609. doi: 10.3389/fimmu.2018.02609. eCollection 2018.
• [15] SENP1 regulates IFN--STAT1 signaling through STAT3-SOCS3 negative feedback loop.J Mol Cell Biol. 2017 Apr 1;9(2):144-153. doi: 10.1093/jmcb/mjw042.
• [16] CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production.PLoS Pathog. 2013;9(6):e1003455. doi: 10.1371/journal.ppat.1003455. Epub 2013 Jun 27.
• [17] RAPD- and actA gene-typing of Listeria monocytogenes isolates of human listeriosis, the intestinal contents of cows and beef.Microbiol Immunol. 2001;45(2):127-33. doi: 10.1111/j.1348-0421.2001.tb01280.x.
• [18] A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.Science. 2011 Mar 11;331(6022):1319-21. doi: 10.1126/science.1200120. Epub 2011 Jan 20.
• [19] Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.J Biol Chem. 2010 Jun 25;285(26):19921-6. doi: 10.1074/jbc.M110.127480. Epub 2010 Apr 12.
• [20] The intrinsic cephalosporin resistome of Listeria monocytogenes in the context of stress response, gene regulation, pathogenesis and therapeutics.J Appl Microbiol. 2016 Feb;120(2):251-65. doi: 10.1111/jam.12989. Epub 2015 Dec 28.
• [21] CLEC5A is a critical receptor in innate immunity against Listeria infection.Nat Commun. 2017 Aug 21;8(1):299. doi: 10.1038/s41467-017-00356-3.
• [22] A combined use of autolysin p60 and listeriolysin O antigens induces high protective immune responses against Listeria monocytogenes infection.Curr Microbiol. 2012 Dec;65(6):813-8. doi: 10.1007/s00284-012-0238-9. Epub 2012 Sep 23.
• [23] Tolerance of Listeria monocytogenes to Quaternary Ammonium Sanitizers Is Mediated by a Novel Efflux Pump Encoded by emrE.Appl Environ Microbiol. 2015 Nov 20;82(3):939-53. doi: 10.1128/AEM.03741-15. Print 2016 Feb 1.
• [24] The Arsenic Resistance-Associated Listeria Genomic Island LGI2 Exhibits Sequence and Integration Site Diversity and a Propensity for Three Listeria monocytogenes Clones with Enhanced Virulence.Appl Environ Microbiol. 2017 Oct 17;83(21):e01189-17. doi: 10.1128/AEM.01189-17. Print 2017 Nov 1.
• [25] Multilocus sequence typing of outbreak-associated Listeria monocytogenes isolates to identify epidemic clones.Foodborne Pathog Dis. 2010 Mar;7(3):257-65. doi: 10.1089/fpd.2009.0342.
• [26] Phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.J Biol Chem. 2012 Apr 13;287(16):13128-36. doi: 10.1074/jbc.M111.315788. Epub 2012 Feb 18.
• [27] Genomic characterization of Listeria monocytogenes strains involved in a multistate listeriosis outbreak associated with cantaloupe in US.PLoS One. 2012;7(7):e42448. doi: 10.1371/journal.pone.0042448. Epub 2012 Jul 31.
• [28] Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages.Immunogenetics. 2001 Mar;53(2):105-13. doi: 10.1007/s002510100306.