General Information of Disease (ID: DISOF3TK)

Disease Name Germ cell tumour
Synonyms
pediatric germ cell cancer; paediatric germ cell cancer; germ cell tumour; germ cell tumor; pediatric germ cell tumor; pediatric germ cell neoplasm; paediatric germ cell tumour; paediatric germ cell neoplasm; childhood germ cell tumor; childhood germ cell neoplasm
Disease Class 2C80: Testicular cancer
Definition A germ cell tumor that occurs during childhood.
Disease Hierarchy
DIS62070: Germ cell tumor
DIS3CD3W: Childhood neoplasm
DISOF3TK: Germ cell tumour
ICD Code
ICD-11
ICD-11: 2C80.2
Expand ICD-9
1.83E+11
Disease Identifiers
MONDO ID
MONDO_0003751
UMLS CUI
C0279014
MedGen ID
75907

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
EGFR806-specific CAR T cell DM3AD65 Phase 1 CAR T Cell Therapy [1]
HER2-specific CAR T cell DMJKBWO Phase 1 CAR T Cell Therapy [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AFP TTCFEA1 Strong Altered Expression [3]
DFFA TTYVQ9C Strong Biomarker [4]
JUP TTREN0G Strong Biomarker [5]
SLAMF7 TT7ILZ1 Strong Biomarker [6]
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This Disease Is Related to 15 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DND1 OTHLC8TA Limited Biomarker [7]
GDF3 OTD3KGJK Limited Genetic Variation [8]
AKR1E2 OT7GBQEB Strong Altered Expression [9]
ALPG OTCIM29R Strong Biomarker [10]
CLSTN1 OTQN35G2 Strong Biomarker [6]
DHDH OTKA2AL6 Strong Altered Expression [11]
DMRT3 OTNV7F7Q Strong Altered Expression [9]
ITPRID2 OTO3JDX5 Strong Biomarker [6]
MYOZ2 OTMEIQJA Strong Biomarker [6]
PAGE1 OT7SQGM8 Strong Biomarker [12]
PAGE4 OT2VLWT0 Strong Biomarker [12]
PRSS21 OT8ZYC7G Strong Biomarker [13]
SNAI3 OTG9DI66 Strong Altered Expression [14]
TSPY1 OTPY57X4 Strong Biomarker [15]
TSPY3 OTQK3AKI Strong Biomarker [15]
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⏷ Show the Full List of 15 DOT(s)

References

1 ClinicalTrials.gov (NCT03638167) EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors
2 ClinicalTrials.gov (NCT03500991) HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors
3 Epidemiologic study of 230 cases of testicular/paratesticular tumors or masses: 15-year experience of a single center.J Pediatr Surg. 2017 Dec;52(12):2056-2060. doi: 10.1016/j.jpedsurg.2017.08.027. Epub 2017 Sep 4.
4 Mutations in the N-terminal domain of DFF45 in a primary germ cell tumor and in neuroblastoma tumors.Int J Oncol. 2004 Nov;25(5):1297-302.
5 Identification of testicular cancer driver genes by a cross-species comparative oncology approach.Andrology. 2019 Jul;7(4):545-554. doi: 10.1111/andr.12644. Epub 2019 May 13.
6 Economy of Standards: European Association of Urology Guideline Changes Influence Treatment Costs in Stage I Testicular Cancer Patients.Urol Int. 2018;100(3):279-287. doi: 10.1159/000486343. Epub 2018 Mar 7.
7 The role of dead-end in germ-cell tumor development.Ann N Y Acad Sci. 2007 Dec;1120:181-6. doi: 10.1196/annals.1411.006. Epub 2007 Sep 28.
8 Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma.Stem Cells. 2004;22(2):169-79. doi: 10.1634/stemcells.22-2-169.
9 Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers.J Genet Genomics. 2016 Oct 20;43(10):577-585. doi: 10.1016/j.jgg.2016.09.003. Epub 2016 Sep 17.
10 The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors.Hum Pathol. 2007 Oct;38(10):1470-81. doi: 10.1016/j.humpath.2007.03.011. Epub 2007 May 22.
11 Dihydrodiol dehydrogenases regulate the generation of reactive oxygen species and the development of cisplatin resistance in human ovarian carcinoma cells.Cancer Chemother Pharmacol. 2008 May;61(6):979-87. doi: 10.1007/s00280-007-0554-0. Epub 2007 Jul 28.
12 PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10757-62. doi: 10.1073/pnas.95.18.10757.
13 Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors.J Cancer Res Clin Oncol. 2006 Dec;132(12):765-70. doi: 10.1007/s00432-006-0124-6. Epub 2006 Jun 21.
14 Identification and characterization of human SNAIL3 (SNAI3) gene in silico.Int J Mol Med. 2003 Mar;11(3):383-8.
15 Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ.Urol Oncol. 2007 Mar-Apr;25(2):141-6. doi: 10.1016/j.urolonc.2006.08.002.