Details of Disease

General Information of Disease (ID: DISQGE8F)

Disease Name Oligoastrocytoma
Synonyms
WHO grade II mixed glioma; MOA; mixed oligodendroglioma-astrocytoma; mixed astrocytic-oligodendroglial tumor; mixed astrocytic-oligodendroglial tumour; oligoastrocytoma; mixed astrocytoma-oligodendroglioma; mixed astrocytic-oligodendroglial neoplasm; mixed oligo-astrocytoma; glioma, mixed, benign; mixed oligoastrocytoma
Definition A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)
Disease Hierarchy
DIS64UY3: Mixed glioma
DIS9NNT0: Grade II glioma
DISQGE8F: Oligoastrocytoma
Disease Identifiers
MONDO ID
MONDO_0016702
UMLS CUI
C0547065
MedGen ID
154285
Orphanet ID
251656
SNOMED CT ID
253071005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 16 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACVR1 TTJNBQA moderate Biomarker [1]
AR TTKPW01 moderate Biomarker [2]
ESR1 TTZAYWL moderate Biomarker [2]
ESR2 TTOM3J0 moderate Biomarker [2]
FGFR1 TTRLW2X moderate Biomarker [3]
HIF1A TTSN6QU moderate Biomarker [4]
NCOA3 TT124R0 moderate Biomarker [2]
NTRK2 TTKN7QR moderate Biomarker [3]
PTPN11 TT7WUAV moderate Biomarker [3]
DLL3 TT1C9K6 Strong Biomarker [5]
HGF TT4V2JM Strong Biomarker [6]
LATS2 TTML7FG Strong Biomarker [7]
MET TTNDSF4 Strong Biomarker [6]
MMP3 TTUZ2L5 Strong Biomarker [8]
NOTCH1 TTB1STW Strong Biomarker [5]
NOTCH2 TT82FVD Strong Biomarker [5]
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⏷ Show the Full List of 16 DTT(s)
This Disease Is Related to 6 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
KIAA1549 OTA5B18F moderate Biomarker [3]
NDRG1 OTVO66BO moderate Biomarker [4]
NF1 OTC29NHH moderate Biomarker [3]
HEY1 OTJQL0I3 Strong Biomarker [5]
HEY2 OTU4J3ZI Strong Biomarker [5]
LATS1 OTOOCG4R Strong Biomarker [7]
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⏷ Show the Full List of 6 DOT(s)

References

1 Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.Nat Genet. 2014 May;46(5):462-6. doi: 10.1038/ng.2950. Epub 2014 Apr 6.
2 Expression of estrogen receptors, androgen receptor and steroid receptor coactivator-3 is negatively correlated to the differentiation of astrocytic tumors.Cancer Epidemiol. 2014 Jun;38(3):291-7. doi: 10.1016/j.canep.2014.03.001. Epub 2014 Mar 27.
3 Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30.
4 Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers.BMC Genet. 2004 Sep 2;5:27. doi: 10.1186/1471-2156-5-27.
5 Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.Genes Cancer. 2010 Aug;1(8):822-35. doi: 10.1177/1947601910383564.
6 Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. Brain Res Mol Brain Res. 2001 Feb 19;87(1):100-8. doi: 10.1016/s0165-3806(00)00154-1.
7 Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res. 2006 Dec;56(4):450-8. doi: 10.1016/j.neures.2006.09.006. Epub 2006 Oct 17.
8 Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.Chem Biol Interact. 2010 Apr 15;185(1):18-24. doi: 10.1016/j.cbi.2010.02.037. Epub 2010 Feb 25.