General Information of Disease (ID: DIS64UY3)

Disease Name Mixed glioma
Synonyms
mixed neuroglial tumour; mixed neuroglial tumor; mixed neuroglial neoplasm; mixed gliomas; mixed glioma (morphologic abnormality); mixed glioma; mixed glial tumour; mixed glial tumor; mixed glial neoplasm; glioma, mixed, malignant; glioma, mixed
Definition A tumor composed of two or more glial cell types (astrocytes, ependymal cells, and oligodendrocytes).
Disease Hierarchy
DIS5RPEH: Glioma
:
DIS64UY3: Mixed glioma
Disease Identifiers
MONDO ID
MONDO_0003268
UMLS CUI
C0259783
MedGen ID
75477
SNOMED CT ID
22217002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 39 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACVR1 TTJNBQA Limited Biomarker [1]
BMI1 TTIPNSR Limited Biomarker [2]
BRAF TT0EOB8 Limited Biomarker [3]
CAT TTPS279 Limited Biomarker [4]
CCR4 TT7HQD0 Limited Biomarker [5]
CDKN2A TTFTWQ8 Limited Biomarker [6]
CLCN2 TT30NW6 Limited Biomarker [7]
CLCN3 TT8XNZ7 Limited Biomarker [7]
FBXW7 TT29KY7 Limited Biomarker [8]
FGF2 TTGKIED Limited Therapeutic [9]
FGFR1 TTRLW2X Limited Biomarker [3]
FTH1 TT975ZT Limited Biomarker [10]
HLA-A TTHONFT Limited Biomarker [11]
HLA-B TTGS10J Limited Biomarker [11]
IL12A TTRTK6Y Limited Therapeutic [12]
IL12B TTGW72V Limited Therapeutic [12]
MGMT TTJ8DV7 Limited Biomarker [13]
MYB TT8V13P Limited Biomarker [14]
MYLK TT18ETS Limited Biomarker [15]
NTRK1 TTTDVOJ Limited Biomarker [16]
NTRK2 TTKN7QR Limited Biomarker [16]
NTRK3 TTXABCW Limited Biomarker [16]
PLK1 TTH4IP0 Limited Biomarker [17]
RAF1 TTAN5W2 Limited Biomarker [3]
SLC5A5 TTW7HI9 Limited Therapeutic [18]
SOD1 TTP9K3Q Limited Therapeutic [19]
SPP1 TT8ME6I Limited Biomarker [20]
TERT TTQY2EJ Limited Biomarker [6]
TFRC TT8MG4S Limited Biomarker [21]
TNFSF10 TTA5MS9 Limited Therapeutic [22]
TOP2A TTCGY2K Limited Biomarker [23]
GDNF TTF23ML Strong Biomarker [24]
GSTP1 TT40K12 Strong Biomarker [25]
IDH1 TTV2A1R Strong Biomarker [26]
MDK TTV8UE7 Strong Biomarker [27]
ROS1 TTSZ6Y3 Strong Biomarker [28]
STMN1 TT7W5OT Strong Biomarker [29]
TP53 TT12KOD Strong Biomarker [16]
PPM1D TTENJAB Definitive Biomarker [30]
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⏷ Show the Full List of 39 DTT(s)
This Disease Is Related to 18 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
APOD OTT77XW8 Limited Biomarker [31]
ATP1B2 OTYTBYVU Limited Biomarker [31]
ATRX OT77RSQW Limited Biomarker [16]
CDKN2B OTAG24N1 Limited Biomarker [32]
CLCN5 OT9YXZSO Limited Biomarker [7]
DMXL1 OTWVL31L Limited Biomarker [31]
FAM107A OTBG61YZ Limited Biomarker [31]
HLA-C OTV38BUJ Limited Biomarker [11]
HMGN5 OTUUAHVQ Limited Biomarker [33]
MYBL1 OTBJMC2P Limited Biomarker [3]
PHLDB1 OTIRCB6I Limited Biomarker [6]
PSD3 OTTN9B9O Limited Biomarker [31]
QKI OTTAUGLB Limited Biomarker [14]
RTEL1 OTI3PJCT Limited Biomarker [6]
TRIM29 OT2DNESG Limited Biomarker [34]
SUZ12 OT655XF8 Disputed Biomarker [35]
CHI3L1 OT2Z7VJH Strong Biomarker [36]
NF1 OTC29NHH Definitive Biomarker [35]
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⏷ Show the Full List of 18 DOT(s)

References

1 Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.Nat Genet. 2014 May;46(5):451-6. doi: 10.1038/ng.2936. Epub 2014 Apr 6.
2 Bmi-1 promotes glioma angiogenesis by activating NF-B signaling.PLoS One. 2013;8(1):e55527. doi: 10.1371/journal.pone.0055527. Epub 2013 Jan 31.
3 Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.Nat Genet. 2013 Jun;45(6):602-12. doi: 10.1038/ng.2611. Epub 2013 Apr 14.
4 Targeting X box-binding protein-1 (XBP1) enhances sensitivity of glioma cells to oxidative stress.Neuropathol Appl Neurobiol. 2011 Jun;37(4):395-405. doi: 10.1111/j.1365-2990.2010.01155.x.
5 Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy.Cancer Immunol Immunother. 2008 Jan;57(1):123-31. doi: 10.1007/s00262-007-0336-x. Epub 2007 May 24.
6 Genome-wide association study identifies five susceptibility loci for glioma.Nat Genet. 2009 Aug;41(8):899-904. doi: 10.1038/ng.407. Epub 2009 Jul 5.
7 Expression of voltage-gated chloride channels in human glioma cells.J Neurosci. 2003 Jul 2;23(13):5572-82. doi: 10.1523/JNEUROSCI.23-13-05572.2003.
8 Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas.Genes Genet Syst. 2008 Aug;83(4):347-52. doi: 10.1266/ggs.83.347.
9 Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas.J Clin Oncol. 2000 Feb;18(4):708-15. doi: 10.1200/JCO.2000.18.4.708.
10 Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents.Cancer Res. 2011 Mar 15;71(6):2240-9. doi: 10.1158/0008-5472.CAN-10-1375. Epub 2011 Mar 8.
11 Human alloreactive CTL interactions with gliomas and with those having upregulated HLA expression from exogenous IFN-gamma or IFN-gamma gene modification.J Interferon Cytokine Res. 2003 Jul;23(7):379-93. doi: 10.1089/107999003322226032.
12 A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma.Anticancer Drugs. 2008 Feb;19(2):133-42. doi: 10.1097/CAD.0b013e3282f24017.
13 NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.J Clin Oncol. 2009 Dec 10;27(35):5874-80. doi: 10.1200/JCO.2009.23.6497. Epub 2009 Nov 9.
14 MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Nat Genet. 2016 Mar;48(3):273-82. doi: 10.1038/ng.3500. Epub 2016 Feb 1.
15 Glioma migration can be blocked by nontoxic inhibitors of myosin II.Cancer Res. 1999 May 1;59(9):2076-82.
16 The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.Nat Genet. 2014 May;46(5):444-450. doi: 10.1038/ng.2938. Epub 2014 Apr 6.
17 Clinicopathological significance of Polo-like kinase 1 (PLK1) expression in human malignant glioma.Acta Histochem. 2012 Sep;114(5):503-9. doi: 10.1016/j.acthis.2011.09.004. Epub 2011 Oct 13.
18 The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.Cancer Gene Ther. 2003 Jan;10(1):14-22. doi: 10.1038/sj.cgt.7700525.
19 Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.Cancer Res. 2002 Feb 15;62(4):1205-12.
20 Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.Am J Pathol. 2006 May;168(5):1676-85. doi: 10.2353/ajpath.2006.050400.
21 The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer.Clin Immunol. 2006 Nov;121(2):144-58. doi: 10.1016/j.clim.2006.06.010. Epub 2006 Aug 10.
22 Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.PLoS One. 2009;4(2):e4545. doi: 10.1371/journal.pone.0004545. Epub 2009 Feb 20.
23 DNA topoisomerase II-alpha as a proliferation marker in human gliomas: correlation with PCNA expression and patient survival.Clin Neuropathol. 2008 Mar-Apr;27(2):83-90. doi: 10.5414/npp27083.
24 Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci. 2009 Mar;16(3):427-36. doi: 10.1016/j.jocn.2008.06.002. Epub 2009 Jan 12.
25 In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. Clin Cancer Res. 2006 Aug 1;12(15):4523-32. doi: 10.1158/1078-0432.CCR-05-1830.
26 Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.Oncotarget. 2017 Feb 28;8(9):15071-15084. doi: 10.18632/oncotarget.14748.
27 Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ. 2011 Jun;18(6):959-73. doi: 10.1038/cdd.2010.170. Epub 2011 Jan 14.
28 Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas. Cancer Res. 2009 Mar 15;69(6):2180-4. doi: 10.1158/0008-5472.CAN-08-3351. Epub 2009 Mar 10.
29 The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18;99(8):639-52. doi: 10.1093/jnci/djk135.
30 Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.Nat Genet. 2014 Jul;46(7):726-30. doi: 10.1038/ng.2995. Epub 2014 Jun 1.
31 Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction.Int J Cancer. 2006 Nov 15;119(10):2330-8. doi: 10.1002/ijc.22108.
32 Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.Nat Genet. 2009 Aug;41(8):905-8. doi: 10.1038/ng.408. Epub 2009 Jul 5.
33 Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life.Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.
34 ATDC contributes to sustaining the growth and invasion of glioma cells through regulating Wnt/-catenin signaling.Chem Biol Interact. 2019 May 25;305:148-155. doi: 10.1016/j.cbi.2019.03.033. Epub 2019 Mar 29.
35 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
36 CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. Int J Cancer. 2011 Mar 15;128(6):1316-26. doi: 10.1002/ijc.25466.