Details of Disease | DrugMAP

General Information of Disease (ID: DISRXONX)

Disease Name	Scrub typhus
Synonyms	Mite-borne rickettsiosis; Mite-borne typhus; scrub (mite-borne) typhus; chigger-borne typhus; tropical typhus; chigger-borne rickettsiosis; typhus fever due to Rickettsia tsutsugamushi; tsutsugamushi; scrub mite-borne typhus; tsutsugamushi fever; tsutsugamushi disease; Kedani fever; Japanese river fever
Definition	Scrub typhus is a rare dust mite-borne infectious disease caused by the Orientia tsutsugamushi bacterium and characterized clinically by an eruptive fever which is potentially serious.
Disease Hierarchy	DISSOMG4: Bacterial hemorrhagic fever DISJ5JX1: Typhus DISRXONX: Scrub typhus
Disease Identifiers	MONDO ID MONDO_0019365 MESH ID D012612 UMLS CUI C0036472 MedGen ID 48591 Orphanet ID 83317 SNOMED CT ID 271425001

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NLRC5	TTWZC78	Strong	Biomarker	[1]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A10	DTJYKDQ	Strong	Biomarker	[2]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ATG3	OT28VBVK	Strong	Genetic Variation	[3]
COPB2	OT82JIGC	Strong	Biomarker	[4]
GNLY	OTZJKA8C	Strong	Biomarker	[2]
LRSAM1	OTOKWR6C	Strong	Genetic Variation	[5]
PPP1R42	OTN1HRBN	Strong	Biomarker	[6]
PRDX2	OTLWCY9T	Strong	Biomarker	[7]
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⏷ Show the Full List of 6 DOT(s)

References

1	The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway.Infect Immun. 2019 Feb 21;87(3):e00876-18. doi: 10.1128/IAI.00876-18. Print 2019 Mar.
2	A Case Report and Literature Review of Scrub Typhus With Acute Abdomen and Septic Shock in a Child-The Role of Leukocytoclastic Vasculitis and Granulysin.Am J Dermatopathol. 2018 Oct;40(10):767-771. doi: 10.1097/DAD.0000000000001167.
3	Active escape of Orientia tsutsugamushi from cellular autophagy.Infect Immun. 2013 Feb;81(2):552-9. doi: 10.1128/IAI.00861-12. Epub 2012 Dec 10.
4	Orientia tsutsugamushi Ank9 is a multifunctional effector that utilizes a novel GRIP-like Golgi localization domain for Golgi-to-endoplasmic reticulum trafficking and interacts with host COPB2.Cell Microbiol. 2017 Jul;19(7):10.1111/cmi.12727. doi: 10.1111/cmi.12727. Epub 2017 Feb 3.
5	Incidence, risk factors and clinical outcomes of acute kidney injury associated with scrub typhus: a retrospective study of 510 consecutive patients in South Korea (2001-2013).BMJ Open. 2017 Mar 15;7(3):e013882. doi: 10.1136/bmjopen-2016-013882.
6	Climate variability, animal reservoir and transmission of scrub typhus in Southern China.PLoS Negl Trop Dis. 2017 Mar 8;11(3):e0005447. doi: 10.1371/journal.pntd.0005447. eCollection 2017 Mar.
7	Analysis of the 56-kDa type specific antigen gene of Orientia tsutsugamushi from northern Vietnam.PLoS One. 2019 Aug 30;14(8):e0221588. doi: 10.1371/journal.pone.0221588. eCollection 2019.