Details of Disease

General Information of Disease (ID: DISS8O8V)

Disease Name	Chronic bronchitis
Synonyms	bronchitis, chronic
Disease Class	CA20: Bronchitis
Definition	A type of chronic obstructive pulmonary disease characterized by chronic inflammation in the bronchial tree that results in edema, mucus production, obstruction, and reduced airflow to and from the lung alveoli. The most common cause is tobacco smoking. Signs and symptoms include coughing with excessive mucus production, and shortness of breath.
Disease Hierarchy	DISQCIRF: Chronic obstructive pulmonary disease DISBM6EQ: Bronchitis DISS8O8V: Chronic bronchitis
ICD Code	ICD-11 ICD-11: CA20.1 ICD-10 ICD-10: J41, J42 Expand ICD-11 'CA20.1 Expand ICD-10 'J41; 'J42
Disease Identifiers	MONDO ID MONDO_0005607 MESH ID D029481 UMLS CUI C0008677 MedGen ID 3084 HPO ID HP:0004469 SNOMED CT ID 63480004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ceftibuten	DMWV2AG	Approved	Small molecular drug	[1]
Grepafloxacin	DMGLX0T	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 12 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CFTR	TTRLZHP	Limited	Biomarker	[2]
HDAC2	TTSHTOI	moderate	Therapeutic	[3]
CCL11	TTCF05Y	Strong	Altered Expression	[4]
CRAT	TTC8M31	Strong	Biomarker	[5]
HPD	TT8DSFC	Strong	Genetic Variation	[6]
ICAM1	TTA1L39	Strong	Biomarker	[7]
IL5	TTPREZD	Strong	Biomarker	[8]
MPO	TTVCZPI	Strong	Biomarker	[9]
NPY	TT64REZ	Strong	Biomarker	[10]
PDE4A	TTZ97H5	Strong	Genetic Variation	[11]
SLC7A1	TT4S150	Strong	Biomarker	[5]
TRPV6	TTBK14N	Strong	Biomarker	[5]
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⏷ Show the Full List of 12 DTT(s)

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CRACR2B	OT8L843R	Limited	Biomarker	[12]
FAM13A	OTZ6GN0Q	Limited	Biomarker	[12]
AP2A2	OTD1UGUN	moderate	Genetic Variation	[12]
CHID1	OT4DIUKC	moderate	Biomarker	[12]
CFAP221	OTUVNCVZ	Strong	Genetic Variation	[12]
CHRNA3	OTCZQY1U	Strong	Genetic Variation	[12]
CSMD1	OTIVDSC4	Strong	Genetic Variation	[12]
CYS1	OTUXN7CO	Strong	Genetic Variation	[12]
FEV	OTYEC4IR	Strong	Genetic Variation	[13]
FZD8	OTZ9IRFL	Strong	Biomarker	[14]
GIT1	OTHO92S5	Strong	Biomarker	[5]
IL9R	OTILCLXA	Strong	Biomarker	[15]
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⏷ Show the Full List of 12 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.Respir Res. 2019 Sep 2;20(1):200. doi: 10.1186/s12931-019-1170-3.
3	Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation.Can J Physiol Pharmacol. 2012 Jul;90(7):895-902. doi: 10.1139/y2012-079. Epub 2012 Jun 18.
4	Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis.Allergy. 2002 Jan;57(1):17-22.
5	Alternative definitions of chronic bronchitis and their correlation with CT parameters.Int J Chron Obstruct Pulmon Dis. 2018 Jun 13;13:1893-1899. doi: 10.2147/COPD.S164055. eCollection 2018.
6	Sequence variation in the hpd gene of nonencapsulated Haemophilus influenzae isolated from patients with chronic bronchitis.Gene. 1997 May 20;191(1):57-60. doi: 10.1016/s0378-1119(97)00030-9.
7	Anti-inflammatory effect of triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on rat model of chronic bronchitis.Am J Chin Med. 2009;37(2):309-21. doi: 10.1142/S0192415X09006862.
8	Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease.Am J Respir Crit Care Med. 2007 Jun 1;175(11):1125-33. doi: 10.1164/rccm.200602-161OC. Epub 2007 Feb 22.
9	[A study on tumor necrosis factor alpha, macrophage inflammatory protein-2 and myeloperoxidase in blood, broncho-alveolar fluid and lung tissues of rat chronic bronchitis model].Zhonghua Nei Ke Za Zhi. 1999 Aug;38(8):523-6.
10	Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway diseases.Am J Respir Crit Care Med. 1998 Sep;158(3):985-90. doi: 10.1164/ajrccm.158.3.9608104.
11	Cigarette smoke exposure alters phosphodiesterases in human structural lung cells.Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L59-L64. doi: 10.1152/ajplung.00319.2019. Epub 2019 Oct 30.
12	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.Respir Res. 2014 Sep 21;15(1):113. doi: 10.1186/s12931-014-0113-2.
13	Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.Am J Respir Crit Care Med. 2010 Nov 1;182(9):1098-104. doi: 10.1164/rccm.201002-0222OC. Epub 2010 Jul 1.
14	A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.Thorax. 2016 Apr;71(4):312-22. doi: 10.1136/thoraxjnl-2015-206958. Epub 2016 Jan 21.
15	IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma.J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):108-15. doi: 10.1016/s0091-6749(00)90185-4.