Details of Disease

General Information of Disease (ID: DISUBO83)

• Disease Name: Trypanosomiasis
• Synonyms: Trypanosomiases; Trypanosoma infectious disease; Trypanosoma disease or disorder; Trypanosoma caused disease or disorder
• Disease Class: 1D51-1F53: Trypanosomiasis
• Definition: Infection with protozoa of the genus trypanosoma.
• Disease Hierarchy:
  DIS57EB5: Protozoa infectious disease
  DISEM33Q: Infectious disease
  DISUBO83: Trypanosomiasis
• ICD Code: ICD-11: ICD-11: 1D51-1F53
• Disease Identifiers:
  MONDO ID: MONDO_0000940
  MESH ID: D014352
  UMLS CUI: C0041227
  MedGen ID: 52872
  SNOMED CT ID: 78940002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benznidazole	DMC83EU	Approved	Small molecular drug	[1]
Eflornithine	DMJOQM3	Approved	Small molecular drug	[2]
Fexinidazole	DMOYE70	Approved	Small molecular drug	[3]
MELARSOPROL	DMGUZ0W	Approved	Small molecular drug	[1]
Nifurtimox	DMSQLZJ	Approved	Small molecular drug	[4]
Triclosan	DMZUR4N	Approved	Small molecular drug	[5]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SCYX-7158	DM72YIS	Phase 1	Small molecular drug	[6]

This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Azoles	DMBAPZ4	Investigative	NA	[7]
CPD-0905	DMZS4UV	Investigative	NA	[7]
DDD-64558	DM4MNRL	Investigative	NA	[7]
Nitroimidazole	DMMY2S5	Investigative	Small molecular drug	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APOL1	TTDB8PW	Limited	Genetic Variation	[8]
TMPRSS11D	TTWHYC8	Limited	Biomarker	[9]
ADA	TTLP57V	Strong	Biomarker	[10]
BCHE	TT3MSAO	Strong	Biomarker	[11]
IL4	TTLGTKB	Strong	Therapeutic	[12]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
A2M	OTFTX90K	Strong	Biomarker	[13]
APBB3	OTNUTR0N	Strong	Genetic Variation	[14]
PEX14	OT98BZHE	Strong	Biomarker	[15]
PEX3	OTGZ7ME2	Strong	Biomarker	[16]
TBR1	OT14JQT8	Strong	Biomarker	[17]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] ClinicalTrials.gov (NCT01636128) Urinary Biomarker Study With Sulindac and Difluoromethylornithine. U.S. National Institutes of Health.
• [3] ClinicalTrials.gov (NCT02169557) Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study. U.S. National Institutes of Health.
• [4] ClinicalTrials.gov (NCT00906880) Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense HumanAfrican Trypanosomiasis (HAT) in the Meningo-encephalitic Phase. U.S. National Institutes of Health.
• [5] Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
• [6] ClinicalTrials.gov (NCT01533961) Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158. U.S. National Institutes of Health.
• [7] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [8] APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy.PLoS One. 2019 Oct 29;14(10):e0224408. doi: 10.1371/journal.pone.0224408. eCollection 2019.
• [9] The composition and abundance of bacterial communities residing in the gut of Glossina palpalis palpalis captured in two sites of southern Cameroon.Parasit Vectors. 2019 Apr 2;12(1):151. doi: 10.1186/s13071-019-3402-2.
• [10] Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi.Parasitology. 2011 Feb;138(2):201-8. doi: 10.1017/S003118201000123X.
• [11] Trypanosoma evansi: cholinesterase activity in acutely infected Wistar rats.Exp Parasitol. 2010 Jul;125(3):251-5. doi: 10.1016/j.exppara.2010.01.024. Epub 2010 Feb 6.
• [12] Effect of tea tree oil (Melaleuca alternifolia) on the longevity and immune response of rats infected by Trypanosoma evansi.Res Vet Sci. 2014 Jun;96(3):501-6. doi: 10.1016/j.rvsc.2014.03.013. Epub 2014 Mar 31.
• [13] Alpha 2 macroglobulin activity in rats infected with Typanosoma lewisi and treated with cyclophosphamide and its effect on the malignancy of the disease.J Vector Borne Dis. 2007 Jun;44(2):128-36.
• [14] Detection of Trypanosoma brucei rhodesiense in animals from sleeping sickness foci in East Africa using the serum resistance associated (SRA) gene.Acta Trop. 2004 May;90(3):249-54. doi: 10.1016/j.actatropica.2004.01.001.
• [15] Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807.
• [16] Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118520. doi: 10.1016/j.bbamcr.2019.07.015. Epub 2019 Jul 29.
• [17] Unraveling cryptic epizootiology of equid trypanosomosis in Punjab state of India by parasitological and sero-molecular techniques.Acta Trop. 2018 Sep;185:18-26. doi: 10.1016/j.actatropica.2018.04.018. Epub 2018 Apr 23.