Details of Disease

General Information of Disease (ID: DISVCUCR)

• Disease Name: Signet ring cell carcinoma
• Synonyms: signet ring carcinoma; signet ring carcinoma NOS (morphologic abnormality); signet ring cell carcinoma (morphologic abnormality); signet ring cell carcinoma; signet ring cell adenocarcinoma
• Definition: A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland.
• Disease Hierarchy:
  DIS3IHTY: Adenocarcinoma
  DISVCUCR: Signet ring cell carcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0005092
  MESH ID: D018279
  UMLS CUI: C0206696
  MedGen ID: 61663
  SNOMED CT ID: 87737001

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CLDN18	TT6PKBX	Strong	Biomarker	[1]
CTSE	TTLXC4Q	Strong	Biomarker	[2]
EML4	TT92GY4	Strong	Genetic Variation	[3]
REG4	TTVZEHU	Strong	Biomarker	[4]

This Disease Is Related to 11 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NOXO1	OTW29FB4	moderate	Altered Expression	[5]
ARHGAP26	OTNGQU7A	Strong	Biomarker	[1]
ATOH1	OTBZYG2R	Strong	Biomarker	[6]
CADM4	OT0TFMFE	Strong	Genetic Variation	[7]
CCS	OTXHT3QO	Strong	Genetic Variation	[8]
CTNNA1	OTFC725Z	Strong	Genetic Variation	[9]
DOCK11	OTFSTN6A	Strong	Genetic Variation	[10]
GALNT14	OT9BSDDQ	Strong	Genetic Variation	[11]
MUC3A	OTI4XUDY	Strong	Genetic Variation	[12]
RAB33A	OTHHU6WA	Strong	Biomarker	[13]
STARD3	OTSTC5B5	Strong	Genetic Variation	[14]

References

• [1] Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer.Nat Commun. 2018 Jun 30;9(1):2447. doi: 10.1038/s41467-018-04907-0.
• [2] Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.PLoS One. 2013;8(2):e56766. doi: 10.1371/journal.pone.0056766. Epub 2013 Feb 22.
• [3] Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report.Lung Cancer. 2011 Sep;73(3):375-8. doi: 10.1016/j.lungcan.2011.05.016. Epub 2011 Jun 29.
• [4] The role of Reg IV gene and its encoding product in gastric carcinogenesis.Hum Pathol. 2010 Jan;41(1):59-69. doi: 10.1016/j.humpath.2009.06.013. Epub 2009 Sep 8.
• [5] Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach.Free Radic Biol Med. 2007 Dec 15;43(12):1627-38. doi: 10.1016/j.freeradbiomed.2007.08.029. Epub 2007 Sep 14.
• [6] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.Biochem Biophys Res Commun. 2013 Mar 1;432(1):175-81. doi: 10.1016/j.bbrc.2013.01.034. Epub 2013 Jan 16.
• [7] Loss of CADM4 expression is associated with poor prognosis in small intestinal adenocarcinomas.APMIS. 2017 May;125(5):437-443. doi: 10.1111/apm.12684.
• [8] Prognoses of different pathological subtypes of colorectal cancer at different stages: A population-based retrospective cohort study.BMC Gastroenterol. 2019 Oct 10;19(1):164. doi: 10.1186/s12876-019-1083-0.
• [9] Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteria.Gastrointest Endosc. 2018 Feb;87(2):397-404.e2. doi: 10.1016/j.gie.2017.04.016. Epub 2017 Apr 25.
• [10] FHIT mutations in human primary gastric cancer.Cancer Res. 1997 Apr 15;57(8):1435-7.
• [11] Prognostic Stratification of Advanced Gastric Signet Ring Cell Carcinoma by Clinicopathological Factors and GALNT14 Genotype.J Cancer. 2018 Sep 8;9(19):3540-3547. doi: 10.7150/jca.26293. eCollection 2018.
• [12] Mucin phenotypic expression in early signet ring cell carcinoma of the stomach: its relationship with the clinicopathologic factors.Dig Dis Sci. 2004 Mar;49(3):417-24. doi: 10.1023/b:ddas.0000020496.98711.14.
• [13] Expression of DNMTs and genomic DNA methylation in gastric signet ring cell carcinoma.Mol Med Rep. 2013 Sep;8(3):942-8. doi: 10.3892/mmr.2013.1566. Epub 2013 Jul 2.
• [14] Association analysis of ERBB2 amplicon genetic polymorphisms and STARD3 expression with risk of gastric cancer in the Chinese population.Gene. 2014 Feb 10;535(2):225-32. doi: 10.1016/j.gene.2013.11.030. Epub 2013 Nov 28.