Details of Disease

General Information of Disease (ID: DISVQ6I2)

• Disease Name: Spastic paralysis
• Synonyms: ham; HTLV-1 associated myelopathy/tropical spastic paraparesis; Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis; Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis; familial spastic paraparesis, HTLV-1-associated; tropical spastic paraparesis (formerly); myelopathy, HTLV-1-associated; ham/TSP; Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis; HTLV-1-associated myelopathy/tropical spastic paraparesis; tropical spastic paralysis; HTLV-associated myelopathy; tropical spastic paraplegia; TSP; Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis
• Disease Class: MB5Y: Paralytic symptom
• Definition: Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.
• Disease Hierarchy:
  DISN5C4M: Human T-lymphotropic virus 1 infectious disease
  DISOE8QI: Infectious disorder of the nervous system
  DISVQ6I2: Spastic paralysis
• ICD Code:
  ICD-11: ICD-11: MB5Y
  Expand ICD-11: 'MB5Y
• Disease Identifiers:
  MONDO ID: MONDO_0008039
  MESH ID: D015493
  UMLS CUI: C0030481
  OMIM ID: 159580
  MedGen ID: 18298
  Orphanet ID: 289326
  SNOMED CT ID: 714279000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MRX-4TZT	DMG12XA	Phase 1	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CNTN2	TT2Z1WB	Strong	Biomarker	[2]
IFNL3	TTRF4Q2	Strong	Genetic Variation	[3]
KLRC1	TTC4IMS	Strong	Biomarker	[4]

This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HBZ	OTMHGFSS	Limited	Biomarker	[5]
NCKIPSD	OT24UORN	Disputed	Genetic Variation	[6]
KLRD1	OTMYLOV4	Strong	Biomarker	[4]
NRSN1	OT1KKXC8	Strong	Biomarker	[7]
PPP2R2C	OTXK0SDM	Strong	Biomarker	[8]
RAB4A	OT7BL9WW	Strong	Biomarker	[9]
TMED2	OTBLO7RW	Strong	Biomarker	[7]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina.J Med Virol. 2010 Aug;82(8):1438-41. doi: 10.1002/jmv.21833.
• [3] HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene.Mediators Inflamm. 2015;2015:804167. doi: 10.1155/2015/804167. Epub 2015 Nov 1.
• [4] Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers.Blood. 2003 Jul 15;102(2):577-84. doi: 10.1182/blood-2002-09-2855. Epub 2003 Jan 30.
• [5] The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis.Virus Res. 2017 Jan 15;228:1-6. doi: 10.1016/j.virusres.2016.11.009. Epub 2016 Nov 12.
• [6] Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.Infect Genet Evol. 2016 Nov;45:420-425. doi: 10.1016/j.meegid.2016.08.020. Epub 2016 Aug 21.
• [7] Linear antigenic regions of the structural proteins of human T-cell lymphotropic virus type I detected by enzyme-linked immunosorbent assays using synthetic peptides as antigens.J Clin Microbiol. 1992 Feb;30(2):287-90. doi: 10.1128/jcm.30.2.287-290.1992.
• [8] Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis.AIDS Res Hum Retroviruses. 1992 Jul;8(7):1209-13. doi: 10.1089/aid.1992.8.1209.
• [9] Increased seroreactivity to human T cell lymphoma/leukemia virus-related endogenous sequence-1 Gag peptides in patients with human T cell lymphoma/leukemia virus myelopathy.AIDS Res Hum Retroviruses. 2015 Feb;31(2):242-9. doi: 10.1089/AID.2014.0171. Epub 2014 Nov 19.