Details of Disease

General Information of Disease (ID: DISN5C4M)

• Disease Name: Human T-lymphotropic virus 1 infectious disease
• Synonyms: Human T lymphotropic virus type 1; HTLV-1; human T-lymphotropic virus 1 infectious disease; Human T-lymphotropic virus 1 disease or disorder; Human T-lymphotropic virus 1 caused disease or disorder; Human T-lymphotropic virus 1 infectious disease
• Definition: A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder.
• Disease Hierarchy:
  DISFYSIV: Virus infection
  DISEM33Q: Infectious disease
  DISN5C4M: Human T-lymphotropic virus 1 infectious disease
• Disease Identifiers:
  MONDO ID: MONDO_0005801
  MESH ID: D015490
  UMLS CUI: C0020097
  MedGen ID: 6919
  SNOMED CT ID: 429659006

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD3G	TTV3XPL	Disputed	Posttranslational Modification	[1]
MASP2	TTR01E9	Disputed	Genetic Variation	[2]
CNTN2	TT2Z1WB	moderate	Altered Expression	[3]
SERPINH1	TTPSWQG	moderate	Biomarker	[4]
TNFSF4	TTBW580	moderate	Biomarker	[5]
CCR4	TT7HQD0	Strong	Biomarker	[6]
XPO1	TTCJUR4	Strong	Biomarker	[7]

This Disease Is Related to 18 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CENPV	OTPQ0KT9	Disputed	Biomarker	[8]
CNKSR3	OTXP4QH8	Disputed	Altered Expression	[3]
HBZ	OTMHGFSS	Disputed	Biomarker	[9]
IFI16	OT4SPU0U	Disputed	Biomarker	[10]
KIR3DS1	OTJWIO4T	Disputed	Altered Expression	[11]
MAGI1	OTMV4ASV	Disputed	Altered Expression	[3]
POLD4	OTG578YH	Disputed	Biomarker	[12]
POLE4	OTCMWUT6	Disputed	Biomarker	[12]
TAX1BP1	OTGJMGJ9	Disputed	Biomarker	[13]
AHI1	OT8K2YWY	moderate	Genetic Variation	[14]
NCKIPSD	OT24UORN	moderate	Genetic Variation	[14]
AKAP13	OTOZAR14	Strong	Biomarker	[15]
CLEC11A	OT9KBH7C	Strong	Biomarker	[15]
HLA-DMB	OT17HGXJ	Strong	Altered Expression	[16]
NDRG2	OT5L6KD7	Strong	Altered Expression	[17]
NSFL1C	OTIKQF3U	Strong	Biomarker	[15]
PDLIM2	OTEURRPD	Strong	Genetic Variation	[18]
PLEK	OTB73XXA	Strong	Biomarker	[15]

References

• [1] Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing.Virol J. 2007 Sep 6;4:85. doi: 10.1186/1743-422X-4-85.
• [2] Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.J Med Virol. 2013 Oct;85(10):1829-35. doi: 10.1002/jmv.23656. Epub 2013 Jul 16.
• [3] Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1.Cancer Sci. 2013 Mar;104(3):313-20. doi: 10.1111/cas.12087. Epub 2013 Jan 30.
• [4] A novel mother-to-child human T-cell leukaemia virus type 1 (HTLV-1) transmission model for investigating the role of maternal anti-HTLV-1 antibodies using orally infected mother rats.J Gen Virol. 2017 Apr;98(4):835-846. doi: 10.1099/jgv.0.000733. Epub 2017 May 5.
• [5] Human T cell leukemia virus type I (HTLV-I) and human diseases.Annu Rev Immunol. 1997;15:15-37. doi: 10.1146/annurev.immunol.15.1.15.
• [6] Switching and loss of cellular cytokine producing capacity characterize in vivo viral infection and malignant transformation in human T- lymphotropic virus type 1 infection.PLoS Pathog. 2018 Feb 14;14(2):e1006861. doi: 10.1371/journal.ppat.1006861. eCollection 2018 Feb.
• [7] Enhanced replication of human T-cell leukemia virus type 1 in T cells from transgenic rats expressing human CRM1 that is regulated in a natural manner.J Virol. 2007 Jun;81(11):5908-18. doi: 10.1128/JVI.02811-06. Epub 2007 Mar 14.
• [8] Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.Viruses. 2011 Jun;3(6):861-85. doi: 10.3390/v3060861. Epub 2011 Jun 17.
• [9] HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia.JCI Insight. 2019 Oct 3;4(19):e128713. doi: 10.1172/jci.insight.128713.
• [10] IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.FEBS Lett. 2018 May;592(10):1693-1704. doi: 10.1002/1873-3468.13077. Epub 2018 May 14.
• [11] In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection.Hum Immunol. 2012 Aug;73(8):783-7. doi: 10.1016/j.humimm.2012.05.006. Epub 2012 May 17.
• [12] Human T cell lymphotropic virus type I (HTLV-I) p12I is dispensable for HTLV-I transmission and maintenance of infection in vivo.AIDS Res Hum Retroviruses. 2004 Oct;20(10):1092-9. doi: 10.1089/aid.2004.20.1092.
• [13] Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.Autoimmunity. 2015;48(7):453-9. doi: 10.3109/08916934.2015.1070836. Epub 2015 Aug 14.
• [14] Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.Infect Genet Evol. 2016 Nov;45:420-425. doi: 10.1016/j.meegid.2016.08.020. Epub 2016 Aug 21.
• [15] Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-B.Sci Rep. 2019 Mar 5;9(1):3491. doi: 10.1038/s41598-019-39424-7.
• [16] HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation.Sci Rep. 2017 Oct 31;7(1):14416. doi: 10.1038/s41598-017-14882-z.
• [17] The regulation of NDRG2 expression during ATLL development after HTLV-1 infection.Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2633-2646. doi: 10.1016/j.bbadis.2019.07.001. Epub 2019 Jul 8.
• [18] PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation.Blood. 2009 Apr 30;113(18):4370-80. doi: 10.1182/blood-2008-10-185660. Epub 2009 Jan 8.