Details of the Drug Combination

General Information of Drug Combination (ID: DCEOXNJ)

• Drug Combination Name: Sirolimus + Melphalan
• Indication: Graft Versus Host Disease; Status: Phase 2 [1]
• Component Drugs:
  Sirolimus (DMGW1ID): Small molecular drug
  Melphalan (DMOLNHF): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Sirolimus

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[2]
Brainstem neoplasm	N.A.	Approved	[2]
Graft-versus-host disease	4B24	Approved	[2]
Intracranial meningioma	N.A.	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Lung lymphangioleiomyomatosis	N.A.	Approved	[2]
Lymphangioleiomyomatosis	CB07	Approved	[3]
Mucosal melanoma	N.A.	Approved	[2]
Multiple myeloma	2A83	Approved	[4]
Multiple sclerosis	8A40	Approved	[2]
Non-small-cell lung cancer	2C25.Y	Approved	[2]
Organ transplant rejection	NE84	Approved	[5]
Plasma cell myeloma	2A83.1	Approved	[2]
Prostate cancer	2C82.0	Approved	[2]
Salivary gland squamous cell carcinoma	N.A.	Approved	[2]
Uveitis	9A96.Z	Phase 3	[6]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[7]
Dutch elm disease	8D64	Phase 1/2	[5]
Castration-resistant prostate carcinoma	N.A.	Investigative	[2]
Neuroblastoma	2D11.2	Investigative	[2]
Pancreatic acinar cell carcinoma	N.A.	Investigative	[2]
Polycystic kidney disease	GB8Y	Investigative	[2]
Rheumatoid arthritis	FA20	Investigative	[2]

Sirolimus Interacts with 3 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Serine/threonine-protein kinase mTOR (mTOR)	TTCJG29	MTOR_HUMAN	Inhibitor	[13]
PI3K/AKT/mTOR pathway (PAm pathway)	TTGQUFK	NOUNIPROTAC	Inhibitor	[14]
HUMAN mammalian target of rapamycin (mTOR)	TT7HQAF	MTOR_HUMAN	Inhibitor	[15]

Sirolimus Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[16]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[17]

Sirolimus Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[18]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[19]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[19]

Sirolimus Interacts with 3 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Increases ADR	[20]
Calcineurin subunit B type 1 (PPP3R1)	OTGQNFJQ	CANB1_HUMAN	Increases ADR	[20]
Nuclear receptor ROR-gamma (RORC)	OTUBFRPC	RORG_HUMAN	Increases ADR	[20]

Indication(s) of Melphalan

Disease Entry	ICD 11	Status	REF
Hematologic disease	3C0Z	Approved	[8]
Leukemia	N.A.	Approved	[8]
Multiple myeloma	2A83	Approved	[9]
Myeloproliferative neoplasm	2A20	Approved	[8]
Ovarian cancer	2C73	Approved	[10]
Plasma cell myeloma	2A83.1	Approved	[8]
Refractory plasma cell neoplasm	N.A.	Approved	[8]
Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[11]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[12]
Classic Hodgkin lymphoma	N.A.	Investigative	[8]
Neuroblastoma	2D11.2	Investigative	[8]
Retinoblastoma	2D02.2	Investigative	[8]

Melphalan Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[22]

Melphalan Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[23]

Melphalan Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Glutathione S-transferase alpha-1 (GSTA1)	DE4ZHS1	GSTA1_HUMAN	Metabolism	[24]

Melphalan Interacts with 237 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Decreases Activity	[25]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Decreases Activity	[25]
BICD family-like cargo adapter 2 (BICDL2)	OTK1LAIB	BICL2_HUMAN	Increases Expression	[21]
RNA-binding protein MEX3A (MEX3A)	OTB0OEQN	MEX3A_HUMAN	Increases Expression	[21]
Transmembrane protein 131-like (TMEM131L)	OT7MO7XU	T131L_HUMAN	Decreases Expression	[21]
Rho GTPase-activating protein 42 (ARHGAP42)	OTIDSJMK	RHG42_HUMAN	Decreases Expression	[21]
Aryl hydrocarbon receptor repressor (AHRR)	OTSJ12W6	AHRR_HUMAN	Decreases Expression	[21]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[21]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Decreases Expression	[21]
Nucleolar protein 56 (NOP56)	OTT67SRZ	NOP56_HUMAN	Increases Expression	[21]
Pro-neuregulin-2, membrane-bound isoform (NRG2)	OTMDE844	NRG2_HUMAN	Decreases Expression	[21]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Increases Phosphorylation	[26]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Expression	[21]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)	OTRBREQ9	ANR28_HUMAN	Decreases Expression	[21]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Affects Phosphorylation	[27]
NF-kappa-B-repressing factor (NKRF)	OTUVY0P6	NKRF_HUMAN	Increases Expression	[21]
Forkhead box protein P2 (FOXP2)	OTVX6A59	FOXP2_HUMAN	Decreases Expression	[21]
Regulator of G-protein signaling 16 (RGS16)	OTBKZASI	RGS16_HUMAN	Increases Expression	[21]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Increases Expression	[21]
Unconventional myosin-Ib (MYO1B)	OTGZUJ0I	MYO1B_HUMAN	Decreases Expression	[21]
Ephrin-A2 (EFNA2)	OTEAUKRX	EFNA2_HUMAN	Increases Expression	[21]
Kalirin (KALRN)	OT8WRCBH	KALRN_HUMAN	Decreases Expression	[21]
NUAK family SNF1-like kinase 1 (NUAK1)	OTLLHJJQ	NUAK1_HUMAN	Decreases Expression	[21]
TBC1 domain family member 12 (TBC1D12)	OTG0R7NT	TBC12_HUMAN	Decreases Expression	[21]
DNA polymerase zeta catalytic subunit (REV3L)	OT0OP8EJ	REV3L_HUMAN	Decreases Expression	[21]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Decreases Expression	[21]
Dual specificity protein phosphatase CDC14B (CDC14B)	OTAESVOZ	CC14B_HUMAN	Decreases Expression	[21]
Thiamine transporter 1 (SLC19A2)	OTH5SB0M	S19A2_HUMAN	Increases Expression	[21]
Microphthalmia-associated transcription factor (MITF)	OT6XJCZH	MITF_HUMAN	Decreases Expression	[21]
SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2)	OTUWFMCQ	SRGP2_HUMAN	Decreases Expression	[21]
Suppressor of cytokine signaling 5 (SOCS5)	OTN1ABYR	SOCS5_HUMAN	Decreases Expression	[21]
Nebulette (NEBL)	OT2WH1NC	NEBL_HUMAN	Increases Expression	[21]
Thymocyte selection-associated high mobility group box protein TOX (TOX)	OTE8BL5Z	TOX_HUMAN	Decreases Expression	[21]
Fibrinogen silencer-binding protein (RAD54B)	OTMWB2P2	FSBP_HUMAN	Decreases Expression	[21]
Transforming acidic coiled-coil-containing protein 2 (TACC2)	OTW4M7HI	TACC2_HUMAN	Decreases Expression	[21]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[26]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[28]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[21]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Affects Activity	[29]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Increases Expression	[21]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[30]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Increases Expression	[28]
Transcriptional activator GLI3 (GLI3)	OTKDOE94	GLI3_HUMAN	Decreases Expression	[21]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[21]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[31]
Retinoic acid receptor beta (RARB)	OT367U3E	RARB_HUMAN	Decreases Expression	[21]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Decreases Expression	[21]
Interleukin-7 (IL7)	OTT6YSKM	IL7_HUMAN	Decreases Expression	[21]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Decreases Expression	[21]
Interferon regulatory factor 2 (IRF2)	OTAZRUW3	IRF2_HUMAN	Decreases Expression	[21]
Beta-galactosidase (GLB1)	OTB0TKAG	BGAL_HUMAN	Increases Expression	[32]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Increases Expression	[30]
Troponin I, cardiac muscle (TNNI3)	OT65E12V	TNNI3_HUMAN	Increases Expression	[30]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1)	OT5MXG9W	AT2B1_HUMAN	Decreases Expression	[21]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Decreases Expression	[21]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Decreases Expression	[21]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Increases Expression	[21]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Decreases Expression	[21]
Interleukin-12 subunit alpha (IL12A)	OTDQT8GI	IL12A_HUMAN	Increases Expression	[21]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)	OTRA8ZVE	PPIF_HUMAN	Increases Expression	[21]
MHC class II transactivator (CIITA)	OTRJNZFO	C2TA_HUMAN	Decreases Expression	[21]
G protein-coupled receptor kinase 5 (GRK5)	OTJK79EK	GRK5_HUMAN	Decreases Expression	[21]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[21]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Increases Expression	[21]
Protein AF-9 (MLLT3)	OTXH4DDG	AF9_HUMAN	Decreases Expression	[21]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[33]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[21]
Large ribosomal subunit protein uL15 (RPL27A)	OTQQHPL0	RL27A_HUMAN	Increases Expression	[21]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[21]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Increases Expression	[21]
Homeobox protein MOX-2 (MEOX2)	OTKZCJCB	MEOX2_HUMAN	Decreases Expression	[21]
Ephrin-A5 (EFNA5)	OTOH4DRR	EFNA5_HUMAN	Decreases Expression	[21]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Decreases Expression	[21]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[21]
Ephrin type-A receptor 5 (EPHA5)	OTAM0CVX	EPHA5_HUMAN	Decreases Expression	[21]
Growth arrest-specific protein 1 (GAS1)	OTKJXG52	GAS1_HUMAN	Decreases Expression	[21]
GTP-binding protein RAD (RRAD)	OTW2O4GD	RAD_HUMAN	Increases Expression	[21]
Serine/threonine-protein kinase SIK1 (SIK1)	OT6FCHME	SIK1_HUMAN	Increases Expression	[21]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[21]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Increases Expression	[21]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Expression	[21]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B)	OTSFVC82	2ABB_HUMAN	Decreases Expression	[21]
Fatty acid-binding protein 5 (FABP5)	OTNM186C	FABP5_HUMAN	Increases Expression	[21]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Decreases Expression	[21]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)	OTF6OC66	GCNT1_HUMAN	Decreases Expression	[21]
Cyclic AMP-responsive element-binding protein 5 (CREB5)	OTJDUJPI	CREB5_HUMAN	Decreases Expression	[21]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Decreases Expression	[21]
AT-rich interactive domain-containing protein 5A (ARID5A)	OTQT7CG9	ARI5A_HUMAN	Increases Expression	[21]
Homeobox protein EMX2 (EMX2)	OT0V8OYK	EMX2_HUMAN	Decreases Expression	[21]
Dual specificity protein phosphatase 2 (DUSP2)	OTH54FMR	DUS2_HUMAN	Increases Expression	[21]
Protein CBFA2T1 (RUNX1T1)	OT30DED5	MTG8_HUMAN	Decreases Expression	[21]
Nuclear factor 1 A-type (NFIA)	OTDHQ9CG	NFIA_HUMAN	Decreases Expression	[21]
Urea transporter 1 (SLC14A1)	OTH7UUV0	UT1_HUMAN	Decreases Expression	[21]
GRB2-associated-binding protein 1 (GAB1)	OTQKE6V4	GAB1_HUMAN	Decreases Expression	[21]
Cullin-3 (CUL3)	OTDNOAPM	CUL3_HUMAN	Increases Expression	[21]
Beta-1-syntrophin (SNTB1)	OTSRBECI	SNTB1_HUMAN	Decreases Expression	[21]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Decreases Expression	[21]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)	OT5VYOSM	IKKE_HUMAN	Decreases Expression	[21]
Glutamate receptor ionotropic, NMDA 2C (GRIN2C)	OTV7ZA9O	NMDE3_HUMAN	Increases Expression	[21]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A)	OTZBCRGI	2A5A_HUMAN	Decreases Expression	[21]
Mothers against decapentaplegic homolog 2 (SMAD2)	OTC6VB4K	SMAD2_HUMAN	Increases Phosphorylation	[21]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Increases Expression	[21]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[31]
Tigger transposable element-derived protein 2 (TIGD2)	OTRXGZ1X	TIGD2_HUMAN	Decreases Expression	[21]
Fidgetin (FIGN)	OTJF6EZR	FIGN_HUMAN	Decreases Expression	[21]
Testis-expressed protein 30 (TEX30)	OT87WEPQ	TEX30_HUMAN	Increases Expression	[21]
Cyclin-J (CCNJ)	OTCR4WVV	CCNJ_HUMAN	Increases Expression	[21]
Protein furry homolog (FRY)	OT74IAG2	FRY_HUMAN	Decreases Expression	[21]
Janus kinase and microtubule-interacting protein 3 (JAKMIP3)	OT4EDANR	JKIP3_HUMAN	Decreases Expression	[21]
DENN domain-containing protein 4C (DENND4C)	OT8SYN47	DEN4C_HUMAN	Decreases Expression	[21]
BTB/POZ domain-containing protein 8 (BTBD8)	OT3A3RD7	BTBD8_HUMAN	Decreases Expression	[21]
Autophagy-related protein 16-1 (ATG16L1)	OTEOYC5D	A16L1_HUMAN	Increases Expression	[21]
Protein SPT2 homolog (SPTY2D1)	OT1RY99Z	SPT2_HUMAN	Increases Expression	[21]
Ankyrin repeat domain-containing protein 34A (ANKRD34A)	OTI00ROL	AN34A_HUMAN	Decreases Expression	[21]
AMMECR1-like protein (AMMECR1L)	OTFPJEC1	AMERL_HUMAN	Increases Expression	[21]
RPA-related protein RADX (RADX)	OTKV8BMJ	RADX_HUMAN	Decreases Expression	[21]
Repulsive guidance molecule B (RGMB)	OT2DROYU	RGMB_HUMAN	Decreases Expression	[21]
Alpha-(1,3)-fucosyltransferase 10 (FUT10)	OT8TI57X	FUT10_HUMAN	Decreases Expression	[21]
Connector enhancer of kinase suppressor of ras 3 (CNKSR3)	OTXP4QH8	CNKR3_HUMAN	Decreases Expression	[21]
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C)	OTB1MTOI	AB17C_HUMAN	Decreases Expression	[21]
Transmembrane protein 88 (TMEM88)	OTA96YEL	TMM88_HUMAN	Increases Expression	[21]
Actin remodeling regulator NHS (NHS)	OTKE8QAT	NHS_HUMAN	Decreases Expression	[21]
Coiled-coil domain-containing protein 171 (CCDC171)	OT9NL2D9	CC171_HUMAN	Decreases Expression	[21]
BRCA1-A complex subunit Abraxas 1 (ABRAXAS1)	OT1K4J80	ABRX1_HUMAN	Decreases Expression	[21]
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3)	OT6TKZTU	LRIG3_HUMAN	Decreases Expression	[21]
R-spondin-2 (RSPO2)	OT3HHXU0	RSPO2_HUMAN	Decreases Expression	[21]
Protocadherin Fat 4 (FAT4)	OT7QONNV	FAT4_HUMAN	Decreases Expression	[21]
Thrombospondin type-1 domain-containing protein 4 (THSD4)	OTXDBMDC	THSD4_HUMAN	Decreases Expression	[21]
RNA-binding protein MEX3B (MEX3B)	OTPUZ8CW	MEX3B_HUMAN	Increases Expression	[21]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Decreases Expression	[21]
Lysophospholipid acyltransferase 1 (MBOAT1)	OT4XR6TE	MBOA1_HUMAN	Decreases Expression	[21]
Protein MMS22-like (MMS22L)	OTJI0HM9	MMS22_HUMAN	Decreases Expression	[21]
Transmembrane protein 26 (TMEM26)	OTHZCXYB	TMM26_HUMAN	Decreases Expression	[21]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)	OTI0T62C	FGD6_HUMAN	Decreases Expression	[21]
tRNA methyltransferase 10 homolog C (TRMT10C)	OT1L8Q48	TM10C_HUMAN	Increases Expression	[21]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1)	OTTOGO05	EEPD1_HUMAN	Decreases Expression	[21]
E3 ubiquitin-protein ligase RNF144B (RNF144B)	OTN7FCDE	R144B_HUMAN	Decreases Expression	[21]
Ankyrin and armadillo repeat-containing protein (ANKAR)	OTR49F4J	ANKAR_HUMAN	Decreases Expression	[21]
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)	OTKX7P8G	SPRE1_HUMAN	Decreases Expression	[21]
PX domain-containing protein kinase-like protein (PXK)	OTSP1WLK	PXK_HUMAN	Decreases Expression	[21]
Pleckstrin homology-like domain family B member 2 (PHLDB2)	OTDKMB2G	PHLB2_HUMAN	Decreases Expression	[21]
Transmembrane protein 200A (TMEM200A)	OTVJZIOR	T200A_HUMAN	Decreases Expression	[21]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1)	OTZQE7PW	SMS1_HUMAN	Decreases Expression	[21]
Protein FAM90A1 (FAM90A1)	OTN16PUT	F90A1_HUMAN	Decreases Expression	[21]
Copine-8 (CPNE8)	OTO6U97G	CPNE8_HUMAN	Decreases Expression	[21]
Rho GTPase-activating protein 12 (ARHGAP12)	OTTU94AU	RHG12_HUMAN	Decreases Expression	[21]
Cilia- and flagella-associated protein 206 (CFAP206)	OTTKI6A9	CF206_HUMAN	Decreases Expression	[21]
Rho GTPase-activating protein 24 (ARHGAP24)	OTCQCEZS	RHG24_HUMAN	Decreases Expression	[21]
Rho GTPase-activating protein 18 (ARHGAP18)	OTYMJP6H	RHG18_HUMAN	Decreases Expression	[21]
Intraflagellar transport protein 70B (IFT70B)	OT0LHUE4	IT70B_HUMAN	Decreases Expression	[21]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)	OTVG1VG0	NLS1_HUMAN	Increases Expression	[21]
Kelch repeat and BTB domain-containing protein 3 (KBTBD3)	OTTVABNZ	KBTB3_HUMAN	Decreases Expression	[21]
Activin receptor type-1C (ACVR1C)	OTOTYERF	ACV1C_HUMAN	Decreases Expression	[21]
Methylcytosine dioxygenase TET1 (TET1)	OTZDHT1D	TET1_HUMAN	Decreases Expression	[21]
Semaphorin-6D (SEMA6D)	OTU0UAZS	SEM6D_HUMAN	Decreases Expression	[21]
Exocyst complex component 6 (EXOC6)	OTVVD62X	EXOC6_HUMAN	Decreases Expression	[21]
Coiled-coil domain-containing protein 110 (CCDC110)	OT1L2DWU	CC110_HUMAN	Decreases Expression	[21]
Protein FAM110B (FAM110B)	OTLYN2T1	F110B_HUMAN	Decreases Expression	[21]
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1)	OT4WOLA8	ENOX1_HUMAN	Decreases Expression	[21]
CDK5 and ABL1 enzyme substrate 1 (CABLES1)	OTMN4XSX	CABL1_HUMAN	Decreases Expression	[21]
E3 ubiquitin-protein ligase RNF128 (RNF128)	OTJO86CJ	RN128_HUMAN	Decreases Expression	[21]
Sorting nexin-29 (SNX29)	OTYMXH13	SNX29_HUMAN	Decreases Expression	[21]
Protein Shroom3 (SHROOM3)	OTQKC5X2	SHRM3_HUMAN	Decreases Expression	[21]
Protein prune homolog 2 (PRUNE2)	OTGW2974	PRUN2_HUMAN	Decreases Expression	[21]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[21]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)	OTXGJ8N1	P55G_HUMAN	Decreases Expression	[21]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Increases Expression	[21]
PHD finger protein 3 (PHF3)	OTNOYLG9	PHF3_HUMAN	Decreases Expression	[21]
Ras-like protein family member 10A (RASL10A)	OTEXTN6I	RSLAA_HUMAN	Increases Expression	[21]
Disks large homolog 3 (DLG3)	OTH591WK	DLG3_HUMAN	Decreases Expression	[21]
PHD finger protein 21A (PHF21A)	OTU3FFG4	PF21A_HUMAN	Decreases Expression	[21]
AMSH-like protease (STAMBPL1)	OTI4CYTF	STALP_HUMAN	Decreases Expression	[21]
PDZ and LIM domain protein 5 (PDLIM5)	OTLQVV22	PDLI5_HUMAN	Decreases Expression	[21]
ELL-associated factor 1 (EAF1)	OTN27MJW	EAF1_HUMAN	Increases Expression	[21]
Spermatogenesis-associated protein 17 (SPATA17)	OT6SK923	SPT17_HUMAN	Decreases Expression	[21]
Leucine rich adaptor protein 1 (LURAP1)	OTJ1EZDJ	LURA1_HUMAN	Decreases Expression	[21]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)	OTYXJQCW	FGD4_HUMAN	Decreases Expression	[21]
Transcriptional-regulating factor 1 (TRERF1)	OTA7UQF1	TREF1_HUMAN	Decreases Expression	[21]
Cbp/p300-interacting transactivator 4 (CITED4)	OTR6NHI2	CITE4_HUMAN	Increases Expression	[21]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Increases Expression	[21]
SH3 and cysteine-rich domain-containing protein (STAC)	OTRVBSLR	STAC_HUMAN	Decreases Expression	[21]
Lysosomal-trafficking regulator (LYST)	OTIUB1B3	LYST_HUMAN	Decreases Expression	[21]
Ras-like protein family member 11B (RASL11B)	OTHEVZS6	RSLBB_HUMAN	Increases Expression	[21]
Metastasis-associated protein MTA3 (MTA3)	OTIA6C79	MTA3_HUMAN	Decreases Expression	[21]
RNA-binding protein 24 (RBM24)	OTQI1AR1	RBM24_HUMAN	Increases Expression	[21]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Decreases Expression	[21]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5)	OTA0DE43	B3GN5_HUMAN	Increases Expression	[21]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)	OTM3B3OA	TBL1R_HUMAN	Decreases Expression	[21]
Homeobox protein Hox-D1 (HOXD1)	OTN4V9ZF	HXD1_HUMAN	Increases Expression	[21]
CYFIP-related Rac1 interactor A (CYRIA)	OT2VJ767	CYRIA_HUMAN	Decreases Expression	[21]
Talin rod domain-containing protein 1 (TLNRD1)	OTNOLROI	TLRN1_HUMAN	Increases Expression	[21]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Decreases Expression	[21]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[21]
Protein bicaudal C homolog 1 (BICC1)	OTYRKIJ1	BICC1_HUMAN	Decreases Expression	[21]
GRB2-associated and regulator of MAPK protein 1 (GAREM1)	OTQYIOUN	GARE1_HUMAN	Decreases Expression	[21]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5)	OT2MNW8T	PKHA5_HUMAN	Decreases Expression	[21]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)	OTY2AP6T	PKHA2_HUMAN	Decreases Expression	[21]
E3 ubiquitin-protein ligase Jade-2 (JADE2)	OTVG2MYF	JADE2_HUMAN	Decreases Expression	[21]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[21]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)	OTFOJUIQ	PHAG1_HUMAN	Decreases Expression	[21]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Increases Expression	[21]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)	OTE69HV8	B3GN2_HUMAN	Increases Expression	[21]
PH and SEC7 domain-containing protein 3 (PSD3)	OTTN9B9O	PSD3_HUMAN	Decreases Expression	[21]
Formin-2 (FMN2)	OTUY7BSV	FMN2_HUMAN	Decreases Expression	[21]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)	OTY6ZHVA	RGL1_HUMAN	Decreases Expression	[21]
Spermatogenesis-associated protein 7 (SPATA7)	OT78G2IH	SPAT7_HUMAN	Decreases Expression	[21]
Rho GTPase-activating protein 20 (ARHGAP20)	OTG1STV8	RHG20_HUMAN	Decreases Expression	[21]
Coiled-coil and C2 domain-containing protein 2A (CC2D2A)	OTFGRGFR	C2D2A_HUMAN	Decreases Expression	[21]
Kelch-like protein 42 (KLHL42)	OTK6WARI	KLH42_HUMAN	Increases Expression	[21]
E3 ubiquitin-protein ligase HECW2 (HECW2)	OTP2IN12	HECW2_HUMAN	Decreases Expression	[21]
FERM domain-containing protein 4A (FRMD4A)	OTJDTIK2	FRM4A_HUMAN	Decreases Expression	[21]
Protein DBF4 homolog A (DBF4)	OTBL7JHQ	DBF4A_HUMAN	Increases Expression	[21]
Transcription factor COE1 (EBF1)	OTZ61YYH	COE1_HUMAN	Decreases Expression	[21]
Cdc42 effector protein 3 (CDC42EP3)	OTUZ3U9Z	BORG2_HUMAN	Decreases Expression	[21]
Zinc finger protein Helios (IKZF2)	OTZIMARJ	IKZF2_HUMAN	Decreases Expression	[21]
Myocardin-related transcription factor B (MRTFB)	OT9OXGS9	MRTFB_HUMAN	Decreases Expression	[21]
Protein phosphatase 1H (PPM1H)	OTKSVU7S	PPM1H_HUMAN	Decreases Expression	[21]
Activator of basal transcription 1 (ABT1)	OT9YGIDB	ABT1_HUMAN	Increases Expression	[21]
Trinucleotide repeat-containing gene 6B protein (TNRC6B)	OTGVT0SH	TNR6B_HUMAN	Decreases Expression	[21]
Inactive phospholipase C-like protein 2 (PLCL2)	OTK5FDF6	PLCL2_HUMAN	Decreases Expression	[21]
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)	OTSQTPFQ	SHAN2_HUMAN	Decreases Expression	[21]
Sodium channel protein type 8 subunit alpha (SCN8A)	OT0JGIZN	SCN8A_HUMAN	Decreases Expression	[21]
Dexamethasone-induced Ras-related protein 1 (RASD1)	OT2BAJHK	RASD1_HUMAN	Increases Expression	[21]
FERM domain-containing protein 4B (FRMD4B)	OTVI6YFP	FRM4B_HUMAN	Decreases Expression	[21]
Microtubule cross-linking factor 1 (MTCL1)	OTY9ZKHE	MTCL1_HUMAN	Decreases Expression	[21]
Rho family-interacting cell polarization regulator 2 (RIPOR2)	OTXB6LIR	RIPR2_HUMAN	Decreases Expression	[21]
Krueppel-like factor 12 (KLF12)	OTVH4KD4	KLF12_HUMAN	Decreases Expression	[21]
Cytidine deaminase (CDA)	OT3HXP6N	CDD_HUMAN	Decreases Response To Substance	[34]
Microsomal glutathione S-transferase 2 (MGST2)	OT4UGTDO	MGST2_HUMAN	Decreases Response To Substance	[35]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Increases Response To Substance	[36]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases ADR	[20]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Affects Export	[37]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Affects Response To Substance	[38]
T-lymphocyte activation antigen CD80 (CD80)	OTJBLUQE	CD80_HUMAN	Increases ADR	[20]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Decreases Response To Substance	[39]
Fanconi anemia group C protein (FANCC)	OTTIDM3P	FANCC_HUMAN	Increases Response To Substance	[36]
Elongator complex protein 1 (ELP1)	OTYEWBF7	ELP1_HUMAN	Increases ADR	[20]

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