Details of the Drug Combination

General Information of Drug Combination (ID: DCEYZTN)

• Drug Combination Name: ABT-263 + Panobinostat
• Indication: Hodgkin lymphoma; Status: Investigative [1]
• Component Drugs:
  ABT-263 (DMNE56X): Small molecular drug
  Panobinostat (DM58WKG): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: L-1236
  Zero Interaction Potency (ZIP) Score: 7.93
  Bliss Independence Score: 7.553
  Loewe Additivity Score: 1.77
  LHighest Single Agent (HSA) Score: 4.94

Molecular Interaction Atlas of This Drug Combination

Indication(s) of ABT-263

Disease Entry	ICD 11	Status	REF
Myelofibrosis	2A20.2	Phase 3	[2]
Relapsed or refractory chronic lymphocytic leukaemia	2A82.0	Phase 2	[3]
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[4]

ABT-263 Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Apoptosis regulator Bcl-W (BCL-W)	TTQ79W8	B2CL2_HUMAN	Inhibitor	[8]
G1/S-specific cyclin-D1 (CCND1)	TTFCJ7S	CCND1_HUMAN	Inhibitor	[9]
Apoptosis regulator Bcl-2 (BCL-2)	TTJGNVC	BCL2_HUMAN	Inhibitor	[8]
Apoptosis regulator Bcl-xL (BCL-xL)	TTU1E82	B2CL1_HUMAN	Inhibitor	[8]

ABT-263 Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[10]

ABT-263 Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[11]

ABT-263 Interacts with 6 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[12]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Increases Cleavage	[13]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[12]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Cleavage	[13]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Cleavage	[13]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Affects Response To Substance	[12]

Indication(s) of Panobinostat

Disease Entry	ICD 11	Status	REF
Chronic graft versus host disease	N.A.	Approved	[5]
Lung cancer	2C25.0	Approved	[5]
Multiple myeloma	2A83	Approved	[6]
Non-small-cell lung cancer	2C25.Y	Approved	[5]
Plasma cell myeloma	2A83.1	Approved	[5]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[5]
Type-2 diabetes	5A11	Phase 3	[7]
Primary myelofibrosis	2A20.2	Phase 2	[7]

Panobinostat Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Histone deacetylase 1 (HDAC1)	TT6R7JZ	HDAC1_HUMAN	Inhibitor	[17]

Panobinostat Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[18]

Panobinostat Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[19]

Panobinostat Interacts with 1019 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[20]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A)	OTHJQ1DZ	RPB1_HUMAN	Decreases Phosphorylation	[20]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)	OTA6ICI2	NUD4B_HUMAN	Increases Expression	[14]
ADP-ribose glycohydrolase MACROD2 (MACROD2)	OTNQCHC6	MACD2_HUMAN	Decreases Expression	[14]
Transmembrane protein 218 (TMEM218)	OTM46L89	TM218_HUMAN	Decreases Expression	[14]
Cadherin-like and PC-esterase domain-containing protein 1 (CPED1)	OTJJPZOZ	CPED1_HUMAN	Increases Expression	[14]
Killer cell lectin-like receptor subfamily G member 2 (KLRG2)	OTBLEXSC	KLRG2_HUMAN	Increases Expression	[14]
Protein FAM149A (FAM149A)	OTMDM0RI	F149A_HUMAN	Decreases Expression	[14]
Developmental pluripotency-associated 5 protein (DPPA5)	OTLZC371	DPPA5_HUMAN	Increases Expression	[14]
Metalloprotease TIKI2 (TRABD2B)	OTI7B18G	TIKI2_HUMAN	Increases Expression	[14]
RNA binding protein fox-1 homolog 3 (RBFOX3)	OTL0F3D6	RFOX3_HUMAN	Decreases Expression	[14]
Coiled-coil domain-containing protein 69 (CCDC69)	OT43MI0R	CCD69_HUMAN	Increases Expression	[14]
Ras association domain-containing protein 10 (RASSF10)	OTGB7EBG	RASFA_HUMAN	Decreases Expression	[14]
Very-long-chain (HACD1)	OTEC7EP7	HACD1_HUMAN	Increases Expression	[14]
NALCN channel auxiliary factor 1 (NALF1)	OT8OMCFD	NALF1_HUMAN	Decreases Expression	[14]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)	OT7QO47I	RBG10_HUMAN	Increases Expression	[14]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Increases Expression	[14]
Suppressyn (ERVH48-1)	OT303JGE	SUPYN_HUMAN	Increases Expression	[14]
PDZ and LIM domain protein 1 (PDLIM1)	OT4EGCPG	PDLI1_HUMAN	Increases Expression	[14]
Activator of apoptosis harakiri (HRK)	OTR4GWJ0	HRK_HUMAN	Increases Expression	[14]
Proteinase-activated receptor 3 (F2RL2)	OT982ECU	PAR3_HUMAN	Decreases Expression	[14]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Increases Expression	[14]
Sulfotransferase 1C2 (SULT1C2)	OT07MMZS	ST1C2_HUMAN	Increases Expression	[14]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Increases Expression	[14]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)	OTUX45ZF	MFNG_HUMAN	Decreases Expression	[14]
Podocalyxin (PODXL)	OTPNQXF3	PODXL_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase TRIM38 (TRIM38)	OT6SP1M9	TRI38_HUMAN	Increases Expression	[14]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Increases Expression	[14]
Claudin-4 (CLDN4)	OT9C4PZ4	CLD4_HUMAN	Increases Expression	[14]
Class E basic helix-loop-helix protein 40 (BHLHE40)	OTITX14U	BHE40_HUMAN	Increases Expression	[14]
Suppressor of cytokine signaling 2 (SOCS2)	OTBPNKJQ	SOCS2_HUMAN	Increases Expression	[14]
Astrotactin-1 (ASTN1)	OT23FQIB	ASTN1_HUMAN	Decreases Expression	[14]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Decreases Expression	[14]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)	OTFX1KCG	DC1I1_HUMAN	Increases Expression	[14]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1)	OTMH6OWG	TMG1_HUMAN	Increases Expression	[14]
Putative transcription factor Ovo-like 1 (OVOL1)	OTFJ62UI	OVOL1_HUMAN	Increases Expression	[14]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[14]
Tumor necrosis factor ligand superfamily member 11 (TNFSF11)	OTJEPKEQ	TNF11_HUMAN	Increases Expression	[14]
Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4)	OTUYJNBS	ZNT4_HUMAN	Increases Expression	[14]
Interferon regulatory factor 6 (IRF6)	OTKJ44EV	IRF6_HUMAN	Increases Expression	[14]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Decreases Expression	[14]
Semaphorin-3E (SEMA3E)	OTD4S36H	SEM3E_HUMAN	Increases Expression	[14]
Serine/threonine-protein kinase DCLK1 (DCLK1)	OTVSPS98	DCLK1_HUMAN	Increases Expression	[14]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Increases Expression	[14]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Increases Expression	[14]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Increases Expression	[14]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Increases Expression	[14]
Prosaposin receptor GPR37 (GPR37)	OTIMDDI3	GPR37_HUMAN	Increases Expression	[14]
Monocarboxylate transporter 5 (SLC16A4)	OT1YXBKC	MOT5_HUMAN	Increases Expression	[14]
TOX high mobility group box family member 3 (TOX3)	OTC9NR4W	TOX3_HUMAN	Decreases Expression	[14]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Increases Expression	[14]
Regulator of G-protein signaling 5 (RGS5)	OTUY0Q2I	RGS5_HUMAN	Increases Expression	[14]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Decreases Expression	[14]
Rho GTPase-activating protein 6 (ARHGAP6)	OTNVXXFX	RHG06_HUMAN	Increases Expression	[14]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)	OTZKOTDB	ADA12_HUMAN	Decreases Expression	[14]
Proline dehydrogenase 1, mitochondrial (PRODH)	OT7SQ1C7	PROD_HUMAN	Increases Expression	[14]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)	OTIK337D	TGFI1_HUMAN	Increases Expression	[14]
Phospholipid-transporting ATPase IC (ATP8B1)	OTALGS63	AT8B1_HUMAN	Increases Expression	[14]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Decreases Expression	[14]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Increases Expression	[14]
Synaptotagmin-7 (SYT7)	OTBWAOWY	SYT7_HUMAN	Increases Expression	[14]
Protein sprouty homolog 1 (SPRY1)	OT764FXI	SPY1_HUMAN	Decreases Expression	[14]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[14]
Synaptogyrin-1 (SYNGR1)	OT0MBUK5	SNG1_HUMAN	Increases Expression	[14]
Protocadherin-7 (PCDH7)	OTP091X8	PCDH7_HUMAN	Increases Expression	[14]
Kallikrein-8 (KLK8)	OTGVGHXY	KLK8_HUMAN	Increases Expression	[14]
Phospholipid-transporting ATPase IK (ATP8B3)	OTZOGEJO	AT8B3_HUMAN	Increases Expression	[14]
Periplakin (PPL)	OTTM4WDO	PEPL_HUMAN	Increases Expression	[14]
Lymphocyte antigen 75 (LY75)	OTDHBU0N	LY75_HUMAN	Increases Expression	[14]
BMP/retinoic acid-inducible neural-specific protein 1 (BRINP1)	OTEUVSCP	BRNP1_HUMAN	Increases Expression	[14]
Homeobox protein DLX-3 (DLX3)	OTARP5SQ	DLX3_HUMAN	Increases Expression	[14]
Plexin-C1 (PLXNC1)	OTJ5XKYY	PLXC1_HUMAN	Decreases Expression	[14]
Gremlin-1 (GREM1)	OTCK4IGV	GREM1_HUMAN	Increases Expression	[14]
Cyclin-T2 (CCNT2)	OTBDRH1J	CCNT2_HUMAN	Decreases Expression	[14]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[14]
Growth arrest-specific protein 7 (GAS7)	OT0M5TNY	GAS7_HUMAN	Increases Expression	[14]
Protein diaphanous homolog 2 (DIAPH2)	OTBEYFEZ	DIAP2_HUMAN	Increases Expression	[14]
Inward rectifier potassium channel 13 (KCNJ13)	OTG1CNND	KCJ13_HUMAN	Decreases Expression	[14]
Plexin-A2 (PLXNA2)	OTNNBJMQ	PLXA2_HUMAN	Increases Expression	[14]
Frizzled-7 (FZD7)	OTTK3F6E	FZD7_HUMAN	Increases Expression	[14]
Slit homolog 1 protein (SLIT1)	OT35RBNT	SLIT1_HUMAN	Increases Expression	[14]
Slit homolog 3 protein (SLIT3)	OTU8MKEU	SLIT3_HUMAN	Increases Expression	[14]
Probable phospholipid-transporting ATPase IIA (ATP9A)	OT328F1L	ATP9A_HUMAN	Decreases Expression	[14]
Microfibrillar-associated protein 3-like (MFAP3L)	OTNMHSAH	MFA3L_HUMAN	Decreases Expression	[14]
Protein cordon-bleu (COBL)	OTTB4VFQ	COBL_HUMAN	Increases Expression	[14]
Astrotactin-2 (ASTN2)	OTF0W2FJ	ASTN2_HUMAN	Increases Expression	[14]
Calcium-transporting ATPase type 2C member 2 (ATP2C2)	OTGIHTYQ	AT2C2_HUMAN	Increases Expression	[14]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[14]
Core histone macro-H2A.1 (MACROH2A1)	OTV2DQDD	H2AY_HUMAN	Decreases Expression	[14]
Filamin-B (FLNB)	OTPCOYL6	FLNB_HUMAN	Increases Expression	[14]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Increases Expression	[14]
Transforming acidic coiled-coil-containing protein 1 (TACC1)	OTGX20TE	TACC1_HUMAN	Increases Expression	[14]
NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1)	OTLMT95K	NDUB1_HUMAN	Decreases Expression	[14]
Glypican-4 (GPC4)	OTUJ14DW	GPC4_HUMAN	Decreases Expression	[14]
Disabled homolog 1 (DAB1)	OTPL9MA3	DAB1_HUMAN	Decreases Expression	[14]
Src kinase-associated phosphoprotein 2 (SKAP2)	OTSF44KP	SKAP2_HUMAN	Increases Expression	[14]
Forkhead box protein H1 (FOXH1)	OTEXJ9SL	FOXH1_HUMAN	Increases Expression	[14]
PR domain zinc finger protein 1 (PRDM1)	OTQLSVBS	PRDM1_HUMAN	Increases Expression	[14]
Scrapie-responsive protein 1 (SCRG1)	OTBE7V0P	SCRG1_HUMAN	Increases Expression	[14]
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)	OTB4YBVT	S2512_HUMAN	Increases Expression	[14]
Leukocyte cell-derived chemotaxin 1 (CNMD)	OTHND8EL	CNMD_HUMAN	Increases Expression	[14]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[14]
Serine/threonine-protein kinase PAK 3 (PAK3)	OT80M3BV	PAK3_HUMAN	Decreases Expression	[14]
Lysozyme-like protein 6 (LYZL6)	OT6XS67M	LYZL6_HUMAN	Increases Expression	[14]
Retinal dehydrogenase 2 (ALDH1A2)	OTJB560Z	AL1A2_HUMAN	Decreases Expression	[14]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Increases Expression	[14]
Nucleolar protein 4 (NOL4)	OTWI587R	NOL4_HUMAN	Decreases Expression	[14]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11)	OTBOY3WH	KBTBB_HUMAN	Decreases Expression	[14]
Unconventional myosin-Id (MYO1D)	OTP2RGPN	MYO1D_HUMAN	Increases Expression	[14]
Protein transport protein Sec24D (SEC24D)	OTXR3KC9	SC24D_HUMAN	Increases Expression	[14]
Neurofascin (NFASC)	OTBDUXZT	NFASC_HUMAN	Decreases Expression	[14]
Thymocyte selection-associated high mobility group box protein TOX (TOX)	OTE8BL5Z	TOX_HUMAN	Increases Expression	[14]
Glutaminase kidney isoform, mitochondrial (GLS)	OTGOZG2M	GLSK_HUMAN	Increases Expression	[14]
Rho-related BTB domain-containing protein 3 (RHOBTB3)	OT1BFKPH	RHBT3_HUMAN	Increases Expression	[14]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Decreases Expression	[14]
Peripheral-type benzodiazepine receptor-associated protein 1 (TSPOAP1)	OTAM8SGF	RIMB1_HUMAN	Decreases Expression	[14]
Chondroitin sulfate proteoglycan 5 (CSPG5)	OTXFEBWR	CSPG5_HUMAN	Decreases Expression	[14]
Protocadherin-8 (PCDH8)	OTDDOQM2	PCDH8_HUMAN	Increases Expression	[14]
Histone acetyltransferase KAT7 (KAT7)	OTUN98IC	KAT7_HUMAN	Decreases Expression	[14]
Ly6/PLAUR domain-containing protein 3 (LYPD3)	OTLR2PYX	LYPD3_HUMAN	Increases Expression	[14]
Homeobox protein SIX3 (SIX3)	OTP5E3VU	SIX3_HUMAN	Decreases Expression	[14]
Neuroendocrine secretory protein 55 (GNAS)	OTMH8BKJ	GNAS3_HUMAN	Increases Expression	[14]
Claudin-7 (CLDN7)	OTNE0XHQ	CLD7_HUMAN	Increases Expression	[14]
Homeobox protein SIX6 (SIX6)	OTD1RD9D	SIX6_HUMAN	Decreases Expression	[14]
Protein phosphatase 1 regulatory subunit 3D (PPP1R3D)	OTZNC7R2	PPR3D_HUMAN	Increases Expression	[14]
C-X-C motif chemokine 14 (CXCL14)	OTM189TA	CXL14_HUMAN	Increases Expression	[14]
Fibroblast growth factor 19 (FGF19)	OT2DVJWY	FGF19_HUMAN	Increases Expression	[14]
Heat shock 70 kDa protein 4L (HSPA4L)	OT181WZB	HS74L_HUMAN	Increases Expression	[14]
TBC1 domain family member 8 (TBC1D8)	OT2011SS	TBCD8_HUMAN	Decreases Expression	[14]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Increases Expression	[14]
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Increases Expression	[14]
Histone-lysine N-methyltransferase NSD2 (NSD2)	OTQ6SW4R	NSD2_HUMAN	Decreases Expression	[14]
Purine nucleoside phosphorylase (PNP)	OTO5NIJ2	PNPH_HUMAN	Increases Expression	[14]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[14]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[14]
Adenosine deaminase (ADA)	OTOX2872	ADA_HUMAN	Decreases Expression	[14]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Increases Expression	[14]
Serine protease inhibitor Kazal-type 1 (SPINK1)	OTSUVAL2	ISK1_HUMAN	Increases Expression	[14]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Expression	[14]
Proenkephalin-B (PDYN)	OTEJ6430	PDYN_HUMAN	Increases Expression	[14]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Increases Expression	[14]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Increases Expression	[14]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Increases Expression	[14]
Alpha-1-acid glycoprotein 1 (ORM1)	OTZKSBRE	A1AG1_HUMAN	Decreases Expression	[14]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Increases Expression	[14]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Increases Expression	[14]
Ornithine aminotransferase, mitochondrial (OAT)	OTEKO8CT	OAT_HUMAN	Increases Expression	[14]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Increases Expression	[14]
HLA class II histocompatibility antigen gamma chain (CD74)	OTO16X4Q	HG2A_HUMAN	Increases Expression	[14]
Protein S100-B (S100B)	OTHHDS33	S100B_HUMAN	Increases Expression	[14]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[14]
Glycophorin-C (GYPC)	OTOEDR7O	GLPC_HUMAN	Increases Expression	[14]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[14]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Increases Expression	[14]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[14]
Fatty acid-binding protein, heart (FABP3)	OT562DA1	FABPH_HUMAN	Increases Expression	[14]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[14]
Protein kinase C beta type (PRKCB)	OTYQ0656	KPCB_HUMAN	Increases Expression	[14]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[14]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Increases Expression	[14]
Beta-crystallin A3 (CRYBA1)	OT8617WJ	CRBA1_HUMAN	Decreases Expression	[14]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Increases Expression	[14]
Protein S100-A6 (S100A6)	OTHHPZQ8	S10A6_HUMAN	Increases Expression	[14]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[14]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Increases Expression	[14]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Increases Expression	[14]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Increases Expression	[14]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Increases Expression	[14]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[14]
Complement decay-accelerating factor (CD55)	OTZ3HWTO	DAF_HUMAN	Increases Expression	[14]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[14]
Retinol-binding protein 1 (RBP1)	OTRP1MFC	RET1_HUMAN	Increases Expression	[14]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[14]
Tumor-associated calcium signal transducer 2 (TACSTD2)	OTLSZR00	TACD2_HUMAN	Increases Expression	[14]
Protein FAM200B (FAM200B)	OTQMCR8C	F200B_HUMAN	Decreases Expression	[14]
Apelin receptor early endogenous ligand (APELA)	OTYY0P69	ELA_HUMAN	Increases Expression	[14]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[14]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[14]
COUP transcription factor 1 (NR2F1)	OTGWZWYL	COT1_HUMAN	Increases Expression	[14]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Increases Expression	[14]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Increases Expression	[14]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Increases Expression	[14]
Retinoic acid receptor beta (RARB)	OT367U3E	RARB_HUMAN	Increases Expression	[14]
Thyroid hormone receptor beta (THRB)	OTBBIRHZ	THB_HUMAN	Increases Expression	[14]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[14]
Hyaluronan and proteoglycan link protein 1 (HAPLN1)	OTXWR9TJ	HPLN1_HUMAN	Increases Expression	[14]
Microtubule-associated protein 2 (MAP2)	OT6UYT3X	MTAP2_HUMAN	Increases Expression	[14]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Increases Expression	[14]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[14]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Increases Expression	[14]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Increases Expression	[14]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Increases Expression	[14]
Bone morphogenetic protein 2 (BMP2)	OT23T37S	BMP2_HUMAN	Increases Expression	[14]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Increases Expression	[14]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[14]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Increases Expression	[14]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30)	OT9DERT1	GILT_HUMAN	Increases Expression	[14]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Increases Expression	[14]
Lysosome-associated membrane glycoprotein 2 (LAMP2)	OTLUGEJC	LAMP2_HUMAN	Increases Expression	[14]
Phospholipase A2, membrane associated (PLA2G2A)	OT1NY7BF	PA2GA_HUMAN	Increases Expression	[14]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Increases Expression	[14]
Protein C-ets-1 (ETS1)	OT4LVGDN	ETS1_HUMAN	Increases Expression	[14]
Ras-related C3 botulinum toxin substrate 2 (RAC2)	OTAOHFNH	RAC2_HUMAN	Increases Expression	[14]
Prostatic acid phosphatase (ACP3)	OTSIM0YG	PPAP_HUMAN	Increases Expression	[14]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Increases Expression	[14]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[14]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Increases Expression	[14]
Ribosyldihydronicotinamide dehydrogenase (NQO2)	OTGDAJRZ	NQO2_HUMAN	Increases Expression	[14]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Increases Expression	[14]
Solute carrier family 25 member 16 (SLC25A16)	OTTTUL91	GDC_HUMAN	Increases Expression	[14]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Increases Expression	[14]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[14]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Increases Expression	[14]
Atrial natriuretic peptide receptor 3 (NPR3)	OT6MQP3A	ANPRC_HUMAN	Increases Expression	[14]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	OTAKDCMR	KAPCA_HUMAN	Increases Expression	[14]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[14]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Increases Expression	[14]
Galectin-3 (LGALS3)	OTYQT0ZI	LEG3_HUMAN	Increases Expression	[14]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[14]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Increases Expression	[14]
Bone morphogenetic protein 7 (BMP7)	OTYATP2K	BMP7_HUMAN	Increases Expression	[14]
Integrin beta-5 (ITGB5)	OT21MF51	ITB5_HUMAN	Decreases Expression	[14]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)	OT0LQH93	PACA_HUMAN	Increases Expression	[14]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[14]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Decreases Expression	[14]
Hexokinase-1 (HK1)	OTMPHE8O	HXK1_HUMAN	Increases Expression	[14]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Decreases Expression	[14]
Complement receptor type 2 (CR2)	OT90NDLY	CR2_HUMAN	Increases Expression	[14]
Serine protease inhibitor Kazal-type 2 (SPINK2)	OTSFBT0G	ISK2_HUMAN	Increases Expression	[14]
POU domain, class 3, transcription factor 3 (POU3F3)	OT6BBXPD	PO3F3_HUMAN	Increases Expression	[14]
Muscarinic acetylcholine receptor M3 (CHRM3)	OTKSD095	ACM3_HUMAN	Increases Expression	[14]
Protachykinin-1 (TAC1)	OTM842YW	TKN1_HUMAN	Increases Expression	[14]
Serine/threonine-protein kinase MAK (MAK)	OTEU2G41	MAK_HUMAN	Decreases Expression	[14]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Increases Expression	[14]
Neurofibromin (NF1)	OTC29NHH	NF1_HUMAN	Decreases Expression	[14]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Increases Expression	[14]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[14]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Increases Expression	[14]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Increases Expression	[14]
Bone morphogenetic protein 5 (BMP5)	OTC0Y6E0	BMP5_HUMAN	Increases Expression	[14]
Alpha-(1,3)-fucosyltransferase 4 (FUT4)	OTIBXRTL	FUT4_HUMAN	Increases Expression	[14]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Increases Expression	[14]
Fibroblast growth factor receptor 3 (FGFR3)	OTSAXDIL	FGFR3_HUMAN	Increases Expression	[14]
Calretinin (CALB2)	OTSNMCG9	CALB2_HUMAN	Increases Expression	[14]
Carbonic anhydrase 4 (CA4)	OT3K93LZ	CAH4_HUMAN	Decreases Expression	[14]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Expression	[14]
Peptidyl-prolyl cis-trans isomerase B (PPIB)	OTLPH6KN	PPIB_HUMAN	Increases Expression	[14]
Colorectal mutant cancer protein (MCC)	OTQVI1EM	CRCM_HUMAN	Increases Expression	[14]
Paired box protein Pax-7 (PAX7)	OTDMQRPO	PAX7_HUMAN	Increases Expression	[14]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Increases Expression	[14]
Endothelial transcription factor GATA-2 (GATA2)	OTBP2QQ2	GATA2_HUMAN	Increases Expression	[14]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)	OTGP7D5Y	GATA3_HUMAN	Increases Expression	[14]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Increases Expression	[14]
COUP transcription factor 2 (NR2F2)	OTJFS67N	COT2_HUMAN	Decreases Expression	[14]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[14]
Protein kinase C eta type (PRKCH)	OTC498N5	KPCL_HUMAN	Increases Expression	[14]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Increases Expression	[14]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Increases Expression	[14]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Increases Expression	[14]
Myelin protein P0 (MPZ)	OTAR2YXH	MYP0_HUMAN	Increases Expression	[14]
Rhombotin-2 (LMO2)	OTCC370G	RBTN2_HUMAN	Decreases Expression	[14]
Neuropeptide Y receptor type 1 (NPY1R)	OT5DA9DY	NPY1R_HUMAN	Decreases Expression	[14]
Collagen alpha-3(V) chain (COL5A3)	OTCGC4DM	CO5A3_HUMAN	Increases Expression	[14]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Decreases Expression	[14]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Increases Expression	[14]
Threonine--tRNA ligase 1, cytoplasmic (TARS1)	OT0PWST5	SYTC_HUMAN	Increases Expression	[14]
Serum paraoxonase/arylesterase 1 (PON1)	OTD0Z2XO	PON1_HUMAN	Decreases Expression	[14]
Homeobox protein MSX-1 (MSX1)	OT5U41ZP	MSX1_HUMAN	Increases Expression	[14]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)	OT80C3D4	GBRB3_HUMAN	Increases Expression	[14]
Ephrin type-A receptor 3 (EPHA3)	OTZJF3ML	EPHA3_HUMAN	Increases Expression	[14]
Ephrin type-B receptor 2 (EPHB2)	OT8VZ6C5	EPHB2_HUMAN	Decreases Expression	[14]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Increases Expression	[14]
GTP cyclohydrolase 1 feedback regulatory protein (GCHFR)	OTEOT8GI	GFRP_HUMAN	Increases Expression	[14]
Translocator protein (TSPO)	OTSU7ESK	TSPO_HUMAN	Increases Expression	[14]
CAMPATH-1 antigen (CD52)	OT02LDQN	CD52_HUMAN	Increases Expression	[14]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Decreases Expression	[14]
Syndecan-4 (SDC4)	OTKUVUGZ	SDC4_HUMAN	Increases Expression	[14]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[14]
Protein S100-A11 (S100A11)	OTI57KDN	S10AB_HUMAN	Increases Expression	[14]
Neural cell adhesion molecule L1 (L1CAM)	OTNWAQ4Y	L1CAM_HUMAN	Increases Expression	[14]
Gastrin/cholecystokinin type B receptor (CCKBR)	OTQSNXOI	GASR_HUMAN	Decreases Expression	[14]
ETS-related transcription factor Elf-1 (ELF1)	OTV5LKIA	ELF1_HUMAN	Increases Expression	[14]
Intercellular adhesion molecule 3 (ICAM3)	OTTZ5A5D	ICAM3_HUMAN	Increases Expression	[14]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Expression	[14]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)	OT6LIGJP	MA1A1_HUMAN	Increases Expression	[14]
Carbonic anhydrase-related protein (CA8)	OT9Y8GA8	CAH8_HUMAN	Increases Expression	[14]
Prostaglandin E2 receptor EP4 subtype (PTGER4)	OT2GBV06	PE2R4_HUMAN	Increases Expression	[14]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Increases Expression	[14]
Homeobox protein MSX-2 (MSX2)	OT1WDKE1	MSX2_HUMAN	Increases Expression	[14]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Decreases Expression	[14]
Transcription factor SOX-11 (SOX11)	OT4LG7LA	SOX11_HUMAN	Decreases Expression	[14]
Phosphoglucomutase-1 (PGM1)	OT3VM4JX	PGM1_HUMAN	Increases Expression	[14]
Pigment epithelium-derived factor (SERPINF1)	OTWZH98J	PEDF_HUMAN	Decreases Expression	[14]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Increases Expression	[14]
Transgelin-2 (TAGLN2)	OTUXZGDQ	TAGL2_HUMAN	Increases Expression	[14]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Decreases Expression	[14]
Transcription factor SOX-3 (SOX3)	OT1CRCOB	SOX3_HUMAN	Decreases Expression	[14]
Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1)	OTNBHULA	PACR_HUMAN	Increases Expression	[14]
ETS domain-containing protein Elk-3 (ELK3)	OTBM9BHT	ELK3_HUMAN	Increases Expression	[14]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Increases Expression	[14]
Glutamate receptor 3 (GRIA3)	OT34CNBR	GRIA3_HUMAN	Decreases Expression	[14]
Leukemia inhibitory factor receptor (LIFR)	OT36W9O5	LIFR_HUMAN	Increases Expression	[14]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[14]
Excitatory amino acid transporter 1 (SLC1A3)	OTILR60R	EAA1_HUMAN	Increases Expression	[14]
Netrin receptor DCC (DCC)	OT2C1SHW	DCC_HUMAN	Increases Expression	[14]
Tyrosine-protein kinase SYK (SYK)	OTQID87L	KSYK_HUMAN	Increases Expression	[14]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Increases Expression	[14]
Transcription factor GATA-4 (GATA4)	OTQHWAZG	GATA4_HUMAN	Decreases Expression	[14]
Peptidyl-prolyl cis-trans isomerase C (PPIC)	OTY5Q42N	PPIC_HUMAN	Increases Expression	[14]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[14]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)	OTZRWTGA	IQGA1_HUMAN	Increases Expression	[14]
Cytosolic phospholipase A2 (PLA2G4A)	OTE70SOT	PA24A_HUMAN	Increases Expression	[14]
Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2)	OTAOZIGX	GBRB2_HUMAN	Increases Expression	[14]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Increases Expression	[14]
DNA-binding protein inhibitor ID-4 (ID4)	OTPMJ39I	ID4_HUMAN	Increases Expression	[14]
Sodium- and chloride-dependent creatine transporter 1 (SLC6A8)	OT88C8JA	SC6A8_HUMAN	Decreases Expression	[14]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Increases Expression	[14]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Increases Expression	[14]
Transcription factor SOX-2 (SOX2)	OTFAWCAU	SOX2_HUMAN	Decreases Expression	[14]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Increases Expression	[14]
Potassium voltage-gated channel subfamily C member 1 (KCNC1)	OTW9WF1J	KCNC1_HUMAN	Decreases Expression	[14]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Increases Expression	[14]
Neuropeptide Y receptor type 2 (NPY2R)	OTEWQJ6B	NPY2R_HUMAN	Decreases Expression	[14]
Protein ERGIC-53 (LMAN1)	OTYHKDEO	LMAN1_HUMAN	Decreases Expression	[14]
Beta-arrestin-1 (ARRB1)	OT2NJS37	ARRB1_HUMAN	Increases Expression	[14]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Increases Expression	[14]
Selenoprotein P (SELENOP)	OT02B8IR	SEPP1_HUMAN	Increases Expression	[14]
Histamine N-methyltransferase (HNMT)	OT9F303M	HNMT_HUMAN	Increases Expression	[14]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Increases Expression	[14]
Motor neuron and pancreas homeobox protein 1 (MNX1)	OTXP9FH1	MNX1_HUMAN	Increases Expression	[14]
Homeobox protein MOX-1 (MEOX1)	OTJEMT2D	MEOX1_HUMAN	Increases Expression	[14]
Sulfotransferase 1A2 (SULT1A2)	OT7EJ6LQ	ST1A2_HUMAN	Increases Expression	[14]
Matrix metalloproteinase-14 (MMP14)	OT9C197Z	MMP14_HUMAN	Increases Expression	[14]
Protoporphyrinogen oxidase (PPOX)	OT75GZ3K	PPOX_HUMAN	Decreases Expression	[14]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Increases Expression	[14]
LIM/homeobox protein Lhx2 (LHX2)	OTK61NP8	LHX2_HUMAN	Decreases Expression	[14]
ETS translocation variant 1 (ETV1)	OT6PMJIK	ETV1_HUMAN	Decreases Expression	[14]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G)	OTSJYQVQ	SCNNG_HUMAN	Increases Expression	[14]
Probable global transcription activator SNF2L2 (SMARCA2)	OTSGJ8SV	SMCA2_HUMAN	Increases Expression	[14]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Decreases Expression	[14]
Ephrin-A5 (EFNA5)	OTOH4DRR	EFNA5_HUMAN	Decreases Expression	[14]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Increases Expression	[14]
Homeobox protein GBX-2 (GBX2)	OTW0ZI4D	GBX2_HUMAN	Increases Expression	[14]
Beta-crystallin A4 (CRYBA4)	OTQJ5XGE	CRBA4_HUMAN	Decreases Expression	[14]
Integrin alpha-8 (ITGA8)	OTBH8WFD	ITA8_HUMAN	Increases Expression	[14]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Decreases Expression	[14]
Calcipressin-1 (RCAN1)	OT1MVXC7	RCAN1_HUMAN	Increases Expression	[14]
Monocarboxylate transporter 1 (SLC16A1)	OTW1UTZ7	MOT1_HUMAN	Increases Expression	[14]
Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)	OT5YLZIH	CA2D1_HUMAN	Increases Expression	[14]
Ephrin type-A receptor 4 (EPHA4)	OT3AMK0C	EPHA4_HUMAN	Decreases Expression	[14]
Paired mesoderm homeobox protein 1 (PRRX1)	OTTZK5G8	PRRX1_HUMAN	Increases Expression	[14]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5)	OT2H1KDK	PTN5_HUMAN	Decreases Expression	[14]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[14]
Fibroblast growth factor 8 (FGF8)	OTFU0IUW	FGF8_HUMAN	Decreases Expression	[14]
Proteinase-activated receptor 2 (F2RL1)	OTMRMJ8N	PAR2_HUMAN	Increases Expression	[14]
Cadherin-8 (CDH8)	OTS3SRZ6	CADH8_HUMAN	Decreases Expression	[14]
Homeobox protein DLX-6 (DLX6)	OT0FIJHY	DLX6_HUMAN	Decreases Expression	[14]
Transcription factor SOX-10 (SOX10)	OTF25ULQ	SOX10_HUMAN	Increases Expression	[14]
Neurotrypsin (PRSS12)	OT1MYL3L	NETR_HUMAN	Increases Expression	[14]
Claudin-6 (CLDN6)	OTEN8ID2	CLD6_HUMAN	Increases Expression	[14]
Transcription factor SOX-8 (SOX8)	OTEJXYZM	SOX8_HUMAN	Increases Expression	[14]
Potassium channel subfamily K member 10 (KCNK10)	OT93GC7V	KCNKA_HUMAN	Decreases Expression	[14]
Inhibin beta E chain (INHBE)	OTOI2NYG	INHBE_HUMAN	Increases Expression	[14]
Myelin proteolipid protein (PLP1)	OT8CM9CX	MYPR_HUMAN	Increases Expression	[14]
Synaptosomal-associated protein 25 (SNAP25)	OTUIQ81Q	SNP25_HUMAN	Increases Expression	[14]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Increases Expression	[14]
Somatostatin (SST)	OTY75GQH	SMS_HUMAN	Increases Expression	[14]
Rho-related GTP-binding protein RhoE (RND3)	OTXMXPIH	RND3_HUMAN	Increases Expression	[14]
Neurocalcin-delta (NCALD)	OTJZ8UEL	NCALD_HUMAN	Decreases Expression	[14]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)	OTHIXBGW	GBG11_HUMAN	Increases Expression	[14]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[14]
Small ribosomal subunit protein eS24 (RPS24)	OTSNKIL5	RS24_HUMAN	Increases Expression	[14]
Large ribosomal subunit protein eL31 (RPL31)	OTV9E1OE	RL31_HUMAN	Decreases Expression	[14]
Iroquois-class homeodomain protein IRX-1 (IRX1)	OT0ZN9EJ	IRX1_HUMAN	Increases Expression	[14]
Iroquois-class homeodomain protein IRX-3 (IRX3)	OTLJ48FG	IRX3_HUMAN	Increases Expression	[14]
Fractalkine (CX3CL1)	OTPLGI0E	X3CL1_HUMAN	Increases Expression	[14]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Increases Expression	[14]
ETS-related transcription factor Elf-3 (ELF3)	OTUTLEQO	ELF3_HUMAN	Increases Expression	[14]
Protein delta homolog 1 (DLK1)	OTE1VLNB	DLK1_HUMAN	Decreases Expression	[14]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Increases Expression	[14]
Single-stranded DNA-binding protein 2 (SSBP2)	OTYG1G80	SSBP2_HUMAN	Decreases Expression	[14]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB)	OTRWGNBF	LACTB_HUMAN	Increases Expression	[14]
Matrix-remodeling-associated protein 7 (MXRA7)	OTVQLYIY	MXRA7_HUMAN	Decreases Expression	[14]
Low-density lipoprotein receptor-related protein 2 (LRP2)	OTZ6W681	LRP2_HUMAN	Decreases Expression	[14]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B)	OTSFVC82	2ABB_HUMAN	Decreases Expression	[14]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Increases Expression	[14]
Norrin (NDP)	OTGDJ4US	NDP_HUMAN	Decreases Expression	[14]
Sorbitol dehydrogenase (SORD)	OTC44CR6	DHSO_HUMAN	Decreases Expression	[14]
Sodium channel protein type 7 subunit alpha (SCN7A)	OTK05PXY	SCN7A_HUMAN	Decreases Expression	[14]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Increases Expression	[14]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP)	OTFP7AA8	PFKAP_HUMAN	Increases Expression	[14]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[14]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Expression	[14]
Contactin-2 (CNTN2)	OTQG9W7C	CNTN2_HUMAN	Decreases Expression	[14]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Decreases Expression	[14]
Desmocollin-2 (DSC2)	OTODVH8K	DSC2_HUMAN	Increases Expression	[14]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Decreases Expression	[14]
Paired box protein Pax-2 (PAX2)	OTKP1N8F	PAX2_HUMAN	Increases Expression	[14]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Decreases Expression	[14]
POU domain, class 3, transcription factor 1 (POU3F1)	OTYARA94	PO3F1_HUMAN	Decreases Expression	[14]
Histone-lysine N-methyltransferase MECOM (MECOM)	OTP983W8	MECOM_HUMAN	Decreases Expression	[14]
Transducin-like enhancer protein 4 (TLE4)	OT4QEH6T	TLE4_HUMAN	Decreases Expression	[14]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Increases Expression	[14]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Decreases Expression	[14]
Myocyte-specific enhancer factor 2C (MEF2C)	OTZGF1Y5	MEF2C_HUMAN	Increases Expression	[14]
Putative POU domain, class 5, transcription factor 1B (POU5F1B)	OT0FKQ51	P5F1B_HUMAN	Increases Expression	[14]
Protein CBFA2T1 (RUNX1T1)	OT30DED5	MTG8_HUMAN	Increases Expression	[14]
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2)	OT53K8W2	CACB2_HUMAN	Decreases Expression	[14]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Increases Expression	[14]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Increases Expression	[14]
Divergent protein kinase domain 1C (DIPK1C)	OT4POSL2	DIK1C_HUMAN	Decreases Expression	[14]
Cingulin-like protein 1 (CGNL1)	OTRE9DGT	CGNL1_HUMAN	Increases Expression	[14]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)	OTFCO8QX	SIA4A_HUMAN	Increases Expression	[14]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Increases Expression	[14]
Contactin-1 (CNTN1)	OT7RNPEY	CNTN1_HUMAN	Increases Expression	[14]
Forkhead box protein C1 (FOXC1)	OTOWZGYO	FOXC1_HUMAN	Increases Expression	[14]
Glutamate receptor ionotropic, kainate 3 (GRIK3)	OTX6K345	GRIK3_HUMAN	Decreases Expression	[14]
Rho GTPase-activating protein 5 (ARHGAP5)	OTOQELUN	RHG05_HUMAN	Decreases Expression	[14]
Platelet-activating factor acetylhydrolase (PLA2G7)	OT6H6AMO	PAFA_HUMAN	Increases Expression	[14]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Decreases Expression	[14]
RE1-silencing transcription factor (REST)	OTLL92LQ	REST_HUMAN	Increases Expression	[14]
BMP and activin membrane-bound inhibitor homolog (BAMBI)	OTCEJ8W5	BAMBI_HUMAN	Increases Expression	[14]
Noggin (NOG)	OTGRHHPG	NOGG_HUMAN	Increases Expression	[14]
N-myc-interactor (NMI)	OTYVG3NM	NMI_HUMAN	Increases Expression	[14]
Zinc transporter ZIP6 (SLC39A6)	OTCYF466	S39A6_HUMAN	Decreases Expression	[14]
Frizzled-5 (FZD5)	OTXFFY56	FZD5_HUMAN	Decreases Expression	[14]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A)	OTGTAGCV	PPR1A_HUMAN	Increases Expression	[14]
Semaphorin-5A (SEMA5A)	OTUOIOJV	SEM5A_HUMAN	Decreases Expression	[14]
Cullin-3 (CUL3)	OTDNOAPM	CUL3_HUMAN	Decreases Expression	[14]
Cadherin-18 (CDH18)	OTC06P9H	CAD18_HUMAN	Increases Expression	[14]
Ras-related protein Rab-31 (RAB31)	OTMLXQZ0	RAB31_HUMAN	Increases Expression	[14]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Increases Expression	[14]
Laminin subunit gamma-2 (LAMC2)	OTJMTM72	LAMC2_HUMAN	Increases Expression	[14]
Runt-related transcription factor 3 (RUNX3)	OTITK1XD	RUNX3_HUMAN	Increases Expression	[14]
Integrin alpha-9 (ITGA9)	OTHN1IKA	ITA9_HUMAN	Increases Expression	[14]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)	OTTUU92F	ENPP2_HUMAN	Increases Expression	[14]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Increases Expression	[14]
Collagen alpha-3(IX) chain (COL9A3)	OTCUJOEK	CO9A3_HUMAN	Increases Expression	[14]
Ras-related protein Rab-33A (RAB33A)	OTHHU6WA	RB33A_HUMAN	Decreases Expression	[14]
Septin-6 (SEPTIN6)	OTIV9RTK	SEPT6_HUMAN	Increases Expression	[14]
Tripartite motif-containing protein 14 (TRIM14)	OTLQKUG0	TRI14_HUMAN	Increases Expression	[14]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[14]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Decreases Expression	[14]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)	OTKUW1WT	PDE3A_HUMAN	Increases Expression	[14]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Increases Expression	[14]
Protein disulfide-isomerase A5 (PDIA5)	OT76ZSX5	PDIA5_HUMAN	Increases Expression	[14]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)	OTPHGZ19	ITPR2_HUMAN	Increases Expression	[14]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[14]
Metabotropic glutamate receptor 3 (GRM3)	OTJFGE9S	GRM3_HUMAN	Decreases Expression	[14]
AT-rich interactive domain-containing protein 5B (ARID5B)	OTUQ4CQY	ARI5B_HUMAN	Increases Expression	[14]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)	OTTDCUAO	NFAC4_HUMAN	Decreases Expression	[14]
Opioid-binding protein/cell adhesion molecule (OPCML)	OT93PQ6Y	OPCM_HUMAN	Increases Expression	[14]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[14]
Ras GTPase-activating protein 2 (RASA2)	OTL06RG2	RASA2_HUMAN	Decreases Expression	[14]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Increases Expression	[14]
Ephrin type-A receptor 7 (EPHA7)	OT3VC211	EPHA7_HUMAN	Increases Expression	[14]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Expression	[14]
Ryanodine receptor 3 (RYR3)	OT4EHIP4	RYR3_HUMAN	Decreases Expression	[14]
SH2 domain-containing adapter protein B (SHB)	OTF2HSC0	SHB_HUMAN	Increases Expression	[14]
Homeobox protein SIX1 (SIX1)	OT70YYWM	SIX1_HUMAN	Increases Expression	[14]
ALX homeobox protein 1 (ALX1)	OTZVARA5	ALX1_HUMAN	Increases Expression	[14]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Decreases Expression	[14]
Metallophosphoesterase MPPED2 (MPPED2)	OT7XLMJ6	MPPD2_HUMAN	Decreases Expression	[14]
Mothers against decapentaplegic homolog 2 (SMAD2)	OTC6VB4K	SMAD2_HUMAN	Decreases Expression	[14]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[14]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Increases Expression	[14]
Laminin subunit alpha-4 (LAMA4)	OTHI7TA0	LAMA4_HUMAN	Increases Expression	[14]
Exostosin-1 (EXT1)	OTRPALJK	EXT1_HUMAN	Decreases Expression	[14]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Decreases Expression	[14]
Prostasin (PRSS8)	OT5KLL35	PRSS8_HUMAN	Increases Expression	[14]
Gamma-interferon-inducible protein 16 (IFI16)	OT4SPU0U	IF16_HUMAN	Increases Expression	[14]
Melanoma-derived growth regulatory protein (MIA)	OTG5FN5S	MIA_HUMAN	Increases Expression	[14]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[14]
Dual specificity protein phosphatase 5 (DUSP5)	OTH96RA7	DUS5_HUMAN	Increases Expression	[14]
NADP-dependent malic enzyme, mitochondrial (ME3)	OT3XMLYG	MAON_HUMAN	Decreases Expression	[14]
Reticulon-1 (RTN1)	OTCX1SMK	RTN1_HUMAN	Decreases Expression	[14]
Receptor-type tyrosine-protein phosphatase O (PTPRO)	OTFLKWOY	PTPRO_HUMAN	Decreases Expression	[14]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Increases Expression	[14]
Protein inscuteable homolog (INSC)	OTP16ERR	INSC_HUMAN	Increases Expression	[14]
Inverted formin-2 (INF2)	OT8ZM13C	INF2_HUMAN	Increases Expression	[14]
MHC class I polypeptide-related sequence B (MICB)	OTS2DVDW	MICB_HUMAN	Increases Expression	[14]
Centrosomal protein kizuna (KIZ)	OT5VCKSM	KIZ_HUMAN	Decreases Expression	[14]
UPF0561 protein C2orf68 (C2ORF68)	OTNNFK6R	CB068_HUMAN	Decreases Expression	[14]
FH1/FH2 domain-containing protein 3 (FHOD3)	OT1WUBQX	FHOD3_HUMAN	Decreases Expression	[14]
Complement component receptor 1-like protein (CR1L)	OTX3KR7U	CR1L_HUMAN	Increases Expression	[14]
Transcription factor RFX4 (RFX4)	OTYFRHPA	RFX4_HUMAN	Increases Expression	[14]
Cell cycle control protein 50B (TMEM30B)	OTNSBH84	CC50B_HUMAN	Increases Expression	[14]
Transcription factor Sp6 (SP6)	OTRAB1PN	SP6_HUMAN	Increases Expression	[14]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)	OTCH86VF	AL1L2_HUMAN	Increases Expression	[14]
Synaptic vesicle glycoprotein 2C (SV2C)	OTIH108W	SV2C_HUMAN	Increases Expression	[14]
Uncharacterized protein C8orf34 (C8ORF34)	OTXCTHDG	CH034_HUMAN	Increases Expression	[14]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON)	OT81X593	CDON_HUMAN	Increases Expression	[14]
Extracellular tyrosine-protein kinase PKDCC (PKDCC)	OTVXJR26	PKDCC_HUMAN	Increases Expression	[14]
Raftlin-2 (RFTN2)	OT4WYAD9	RFTN2_HUMAN	Increases Expression	[14]
Seizure protein 6 homolog (SEZ6)	OTCD8K5D	SEZ6_HUMAN	Increases Expression	[14]
Acyl-coenzyme A synthetase ACSM3, mitochondrial (ACSM3)	OT0AE1IV	ACSM3_HUMAN	Increases Expression	[14]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[14]
Rho GTPase-activating protein 15 (ARHGAP15)	OT9CKHDC	RHG15_HUMAN	Decreases Expression	[14]
Fibulin-7 (FBLN7)	OT1XRDP6	FBLN7_HUMAN	Decreases Expression	[14]
Cordon-bleu protein-like 1 (COBLL1)	OTQFN1TC	COBL1_HUMAN	Increases Expression	[14]
Protein Largen (PRR16)	OTG4TEGR	LARGN_HUMAN	Increases Expression	[14]
TPA-induced transmembrane protein (C3ORF52)	OTI0JAT8	TTMP_HUMAN	Increases Expression	[14]
FRAS1-related extracellular matrix protein 1 (FREM1)	OTMHRV87	FREM1_HUMAN	Increases Expression	[14]
Solute carrier family 25 member 53 (SLC25A53)	OTNHVTOB	S2553_HUMAN	Decreases Expression	[14]
Protein BEX5 (BEX5)	OTZ2RB6L	BEX5_HUMAN	Increases Expression	[14]
Protein phosphatase 1J (PPM1J)	OTM6GDJJ	PPM1J_HUMAN	Increases Expression	[14]
Uncharacterized protein KIAA1755 (KIAA1755)	OT1FCGEW	K1755_HUMAN	Increases Expression	[14]
Collectin-12 (COLEC12)	OTIQTK9G	COL12_HUMAN	Increases Expression	[14]
EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT)	OT4A2A8P	EOGT_HUMAN	Increases Expression	[14]
Neurite extension and migration factor (NEXMIF)	OT576F40	NEXMI_HUMAN	Decreases Expression	[14]
Uncharacterized protein C6orf141 (C6ORF141)	OTUS3SIQ	CF141_HUMAN	Decreases Expression	[14]
Centrosomal protein of 85 kDa-like (CEP85L)	OTSHJFOT	CE85L_HUMAN	Increases Expression	[14]
Transmembrane protein 170B (TMEM170B)	OT4AS8RJ	T170B_HUMAN	Decreases Expression	[14]
Protein FAM162B (FAM162B)	OTZ31RP5	F162B_HUMAN	Increases Expression	[14]
LINE-1 type transposase domain-containing protein 1 (L1TD1)	OTB2W20Y	LITD1_HUMAN	Increases Expression	[14]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4)	OT5WC0Q8	KANK4_HUMAN	Increases Expression	[14]
Transcription factor HES-5 (HES5)	OTW7JEHV	HES5_HUMAN	Decreases Expression	[14]
PX domain-containing protein 1 (PXDC1)	OTQUA3TG	PXDC1_HUMAN	Increases Expression	[14]
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF3)	OTGQV0CU	BIG3_HUMAN	Decreases Expression	[14]
Glycoprotein endo-alpha-1,2-mannosidase-like protein (MANEAL)	OT248IN0	MANEL_HUMAN	Increases Expression	[14]
G kinase-anchoring protein 1 (GKAP1)	OTHZRJ56	GKAP1_HUMAN	Decreases Expression	[14]
Myomegalin (PDE4DIP)	OTS15WNF	MYOME_HUMAN	Increases Expression	[14]
Uncharacterized protein C1orf53 (C1ORF53)	OTQTOA4D	CA053_HUMAN	Decreases Expression	[14]
Scm-like with four MBT domains protein 2 (SFMBT2)	OTZQT61Q	SMBT2_HUMAN	Increases Expression	[14]
DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2)	OTLEF5TY	DC122_HUMAN	Decreases Expression	[14]
Proteasome adapter and scaffold protein ECM29 (ECPAS)	OT1C0KOI	ECM29_HUMAN	Decreases Expression	[14]
B box and SPRY domain-containing protein (BSPRY)	OTVVZRKY	BSPRY_HUMAN	Increases Expression	[14]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Increases Expression	[14]
Metalloreductase STEAP3 (STEAP3)	OTS9GZK5	STEA3_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase RNF43 (RNF43)	OT2R9YDP	RNF43_HUMAN	Increases Expression	[14]
LIM/homeobox protein Lhx8 (LHX8)	OT0DFL7C	LHX8_HUMAN	Increases Expression	[14]
Transcription factor Sp5 (SP5)	OT4HUP9B	SP5_HUMAN	Increases Expression	[14]
Tyrosine-protein kinase STYK1 (STYK1)	OT61CSU7	STYK1_HUMAN	Increases Expression	[14]
Volume-regulated anion channel subunit LRRC8E (LRRC8E)	OTUZTANF	LRC8E_HUMAN	Increases Expression	[14]
MFS-type transporter SLC18B1 (SLC18B1)	OT9EVUN1	S18B1_HUMAN	Increases Expression	[14]
TMF-regulated nuclear protein 1 (TRNP1)	OTYYV8LN	TRNP1_HUMAN	Increases Expression	[14]
Epithelial splicing regulatory protein 1 (ESRP1)	OTNCS4SL	ESRP1_HUMAN	Increases Expression	[14]
Cdc42 effector protein 5 (CDC42EP5)	OTQQDUCD	BORG3_HUMAN	Increases Expression	[14]
Protein C3orf33 (C3ORF33)	OTP8MJAN	CC033_HUMAN	Decreases Expression	[14]
DENN domain-containing protein 1B (DENND1B)	OT3VCNPE	DEN1B_HUMAN	Decreases Expression	[14]
Phospholipase B-like 1 (PLBD1)	OTHYEB4W	PLBL1_HUMAN	Increases Expression	[14]
Polypeptide N-acetylgalactosaminyltransferase 18 (GALNT18)	OTKIIELC	GLT18_HUMAN	Increases Expression	[14]
Volume-regulated anion channel subunit LRRC8B (LRRC8B)	OTH2LMJ4	LRC8B_HUMAN	Decreases Expression	[14]
Transmembrane protein 154 (TMEM154)	OTEAFLJE	TM154_HUMAN	Increases Expression	[14]
Transmembrane protein 88 (TMEM88)	OTA96YEL	TMM88_HUMAN	Decreases Expression	[14]
Interleukin-27 receptor subunit alpha (IL27RA)	OTSQBAKI	I27RA_HUMAN	Increases Expression	[14]
Lactase-like protein (LCTL)	OTN36T21	LCTL_HUMAN	Decreases Expression	[14]
Layilin (LAYN)	OT9A9Q1X	LAYN_HUMAN	Increases Expression	[14]
ALK and LTK ligand 2 (ALKAL2)	OTTLHL64	ALKL2_HUMAN	Increases Expression	[14]
Inactive serine protease PAMR1 (PAMR1)	OT83ZH5U	PAMR1_HUMAN	Decreases Expression	[14]
Nephronectin (NPNT)	OTFZAO1G	NPNT_HUMAN	Increases Expression	[14]
Interleukin-20 receptor subunit beta (IL20RB)	OTHFXK95	I20RB_HUMAN	Increases Expression	[14]
R-spondin-2 (RSPO2)	OT3HHXU0	RSPO2_HUMAN	Decreases Expression	[14]
Transmembrane channel-like protein 5 (TMC5)	OTO5D86M	TMC5_HUMAN	Increases Expression	[14]
Transmembrane protein 64 (TMEM64)	OTO9IDFD	TMM64_HUMAN	Increases Expression	[14]
Nesprin-3 (SYNE3)	OTEOJBYB	SYNE3_HUMAN	Increases Expression	[14]
Metastasis-associated in colon cancer protein 1 (MACC1)	OTV3DLX0	MACC1_HUMAN	Increases Expression	[14]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Increases Expression	[14]
Lysophospholipid acyltransferase 1 (MBOAT1)	OT4XR6TE	MBOA1_HUMAN	Increases Expression	[14]
FYVE, RhoGEF and PH domain-containing protein 5 (FGD5)	OT5VIRP2	FGD5_HUMAN	Increases Expression	[14]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1)	OTVILUUN	SO4C1_HUMAN	Increases Expression	[14]
RNA-binding protein with multiple splicing 2 (RBPMS2)	OTY24L1F	RBPS2_HUMAN	Increases Expression	[14]
Leucine-rich repeat-containing protein 55 (LRRC55)	OT8LQI1W	LRC55_HUMAN	Decreases Expression	[14]
RNA-binding protein 43 (RBM43)	OTANIFBG	RBM43_HUMAN	Increases Expression	[14]
Acyl-CoA dehydrogenase family member 11 (ACAD11)	OT3T9HAX	ACD11_HUMAN	Increases Expression	[14]
BTB/POZ domain-containing protein KCTD1 (KCTD1)	OT89U5MB	KCTD1_HUMAN	Increases Expression	[14]
Mediator of RNA polymerase II transcription subunit 13-like (MED13L)	OTSP1W0F	MD13L_HUMAN	Increases Expression	[14]
Eukaryotic translation initiation factor 3 subunit M (EIF3M)	OTVWEV60	EIF3M_HUMAN	Decreases Expression	[14]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2)	OT3N88Q1	LIGO2_HUMAN	Increases Expression	[14]
CXXC-type zinc finger protein 5 (CXXC5)	OTGCN3B5	CXXC5_HUMAN	Increases Expression	[14]
Carbohydrate sulfotransferase 15 (CHST15)	OTNTM2SP	CHSTF_HUMAN	Increases Expression	[14]
Monocarboxylate transporter 14 (SLC16A14)	OTUGDEUV	MOT14_HUMAN	Decreases Expression	[14]
C-myc promoter-binding protein (DENND4A)	OT8FFZ29	MYCPP_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase RNF144B (RNF144B)	OTN7FCDE	R144B_HUMAN	Increases Expression	[14]
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein (BNIPL)	OTDHOA74	BNIPL_HUMAN	Increases Expression	[14]
Cilia- and flagella-associated protein 91 (CFAP91)	OTVDRDGX	CFA91_HUMAN	Decreases Expression	[14]
Transmembrane protein 144 (TMEM144)	OT66EYSR	TM144_HUMAN	Increases Expression	[14]
Uncharacterized protein C11orf96 (C11ORF96)	OTEQU0V7	CK096_HUMAN	Increases Expression	[14]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Increases Expression	[14]
Armadillo-like helical domain-containing protein 4 (ARMH4)	OT25GBJM	ARMD4_HUMAN	Decreases Expression	[14]
Sodium/hydrogen exchanger 9B2 (SLC9B2)	OTZVOY8T	SL9B2_HUMAN	Decreases Expression	[14]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)	OTXDDKZS	MAGI2_HUMAN	Increases Expression	[14]
Regulating synaptic membrane exocytosis protein 1 (RIMS1)	OT10T7CK	RIMS1_HUMAN	Increases Expression	[14]
Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5)	OTP46PZM	ITIH5_HUMAN	Increases Expression	[14]
Protein FAM124A (FAM124A)	OTF1DJX0	F124A_HUMAN	Decreases Expression	[14]
Glucocorticoid-induced transcript 1 protein (GLCCI1)	OTU0R1CU	GLCI1_HUMAN	Decreases Expression	[14]
Four-jointed box protein 1 (FJX1)	OT8SVTSS	FJX1_HUMAN	Decreases Expression	[14]
Catechol O-methyltransferase domain-containing protein 1 (COMTD1)	OTLQJTBI	CMTD1_HUMAN	Increases Expression	[14]
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1)	OTHH06X8	SESD1_HUMAN	Decreases Expression	[14]
Juxtaposed with another zinc finger protein 1 (JAZF1)	OTXTYSYD	JAZF1_HUMAN	Increases Expression	[14]
Myotubularin-related protein 13 (SBF2)	OTBB8NO8	MTMRD_HUMAN	Increases Expression	[14]
Ras association domain-containing protein 3 (RASSF3)	OT4V9SRK	RASF3_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase TRIM69 (TRIM69)	OTTEGTRD	TRI69_HUMAN	Increases Expression	[14]
Probable D-lactate dehydrogenase, mitochondrial (LDHD)	OTTKLJWP	LDHD_HUMAN	Increases Expression	[14]
Chondroitin sulfate synthase 1 (CHSY1)	OTB1XSSF	CHSS1_HUMAN	Increases Expression	[14]
Dynein regulatory complex protein 11 (IQCA1)	OTFBF3FI	DRC11_HUMAN	Increases Expression	[14]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)	OTVCRXEZ	PPR3B_HUMAN	Increases Expression	[14]
Collagen alpha-1(XXIII) chain (COL23A1)	OTYE0N3I	CONA1_HUMAN	Increases Expression	[14]
Testis development-related protein (TDRP)	OTEFLMGF	TDRP_HUMAN	Increases Expression	[14]
Podoplanin (PDPN)	OTBUV19I	PDPN_HUMAN	Increases Expression	[14]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)	OTN6FKCB	PRGC2_HUMAN	Increases Expression	[14]
Rab11 family-interacting protein 4 (RAB11FIP4)	OTIGHER7	RFIP4_HUMAN	Increases Expression	[14]
Inactive tyrosine-protein kinase PRAG1 (PRAG1)	OTV83SGI	PRAG1_HUMAN	Increases Expression	[14]
Purine nucleoside phosphorylase LACC1 (LACC1)	OT4SBHI8	LACC1_HUMAN	Increases Expression	[14]
LysM and putative peptidoglycan-binding domain-containing protein 2 (LYSMD2)	OT1VCC2M	LYSM2_HUMAN	Increases Expression	[14]
Proline-rich protein 15 (PRR15)	OTJHSY8G	PRR15_HUMAN	Increases Expression	[14]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Increases Expression	[14]
Immunoglobulin superfamily DCC subclass member 3 (IGDCC3)	OTGR1KA4	IGDC3_HUMAN	Increases Expression	[14]
Sodium channel subunit beta-4 (SCN4B)	OT3JSUWO	SCN4B_HUMAN	Increases Expression	[14]
Sphingosine-1-phosphate phosphatase 2 (SGPP2)	OTIDIJCR	SGPP2_HUMAN	Increases Expression	[14]
Uncharacterized protein C12orf56 (C12ORF56)	OT4KDTKF	CL056_HUMAN	Increases Expression	[14]
Solute carrier family 35 member F2 (SLC35F2)	OTSAD4EQ	S35F2_HUMAN	Increases Expression	[14]
Transcription factor Sp8 (SP8)	OTLCMPKH	SP8_HUMAN	Decreases Expression	[14]
Procollagen galactosyltransferase 2 (COLGALT2)	OTV9EDZB	GT252_HUMAN	Decreases Expression	[14]
Ras and EF-hand domain-containing protein (RASEF)	OTGSAM2E	RASEF_HUMAN	Increases Expression	[14]
Myocardin (MYOCD)	OTSJNHTH	MYCD_HUMAN	Increases Expression	[14]
Protein SIX6OS1 (C14ORF39)	OTFKQ6HO	S6OS1_HUMAN	Decreases Expression	[14]
Neuroligin-1 (NLGN1)	OTGHRRFQ	NLGN1_HUMAN	Decreases Expression	[14]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[14]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)	OTVLWW9T	GPD1L_HUMAN	Increases Expression	[14]
ELMO domain-containing protein 1 (ELMOD1)	OT0WRVJC	ELMD1_HUMAN	Increases Expression	[14]
Mucin-15 (MUC15)	OT3PQT6L	MUC15_HUMAN	Increases Expression	[14]
Rho GTPase-activating protein 18 (ARHGAP18)	OTYMJP6H	RHG18_HUMAN	Increases Expression	[14]
MICAL-like protein 1 (MICALL1)	OTHG9B2U	MILK1_HUMAN	Increases Expression	[14]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K)	OTNZ4N4E	PPM1K_HUMAN	Increases Expression	[14]
Thioredoxin domain-containing protein 3 (NME8)	OT4RULP5	TXND3_HUMAN	Increases Expression	[14]
Inactive carboxypeptidase-like protein X2 (CPXM2)	OTDJNOTR	CPXM2_HUMAN	Increases Expression	[14]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Decreases Expression	[14]
Protein limb expression 1 homolog (LIX1)	OT1CPNCC	LIX1_HUMAN	Decreases Expression	[14]
RING finger protein 175 (RNF175)	OTKAZ8ZW	RN175_HUMAN	Decreases Expression	[14]
Reprimo-like protein (RPRML)	OTPOESFN	RPRML_HUMAN	Increases Expression	[14]
Serine/threonine-protein kinase DCLK2 (DCLK2)	OTT0AU1C	DCLK2_HUMAN	Decreases Expression	[14]
Ephexin-1 (NGEF)	OT9QUXJ3	NGEF_HUMAN	Increases Expression	[14]
Eukaryotic translation initiation factor 4E type 3 (EIF4E3)	OTTWVS2R	IF4E3_HUMAN	Decreases Expression	[14]
E3 ubiquitin-protein ligase RNF182 (RNF182)	OT08FLHZ	RN182_HUMAN	Decreases Expression	[14]
CUGBP Elav-like family member 5 (CELF5)	OT02OG9N	CELF5_HUMAN	Decreases Expression	[14]
Protocadherin-20 (PCDH20)	OTFSNRXK	PCD20_HUMAN	Increases Expression	[14]
Leucine-rich repeat-containing protein 17 (LRRC17)	OT3NZSX3	LRC17_HUMAN	Increases Expression	[14]
APC membrane recruitment protein 2 (AMER2)	OTA1Q07C	AMER2_HUMAN	Increases Expression	[14]
BMP-binding endothelial regulator protein (BMPER)	OTBYON4H	BMPER_HUMAN	Increases Expression	[14]
V-type proton ATPase subunit d 2 (ATP6V0D2)	OTMOZJO0	VA0D2_HUMAN	Increases Expression	[14]
Tetratricopeptide repeat protein 29 (TTC29)	OT37KCUL	TTC29_HUMAN	Increases Expression	[14]
Fibronectin type III domain-containing protein 5 (FNDC5)	OT5CSK9X	FNDC5_HUMAN	Decreases Expression	[14]
Transmembrane protein 178A (TMEM178A)	OTQZY4NP	T178A_HUMAN	Decreases Expression	[14]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)	OTBIN5IP	SCPDL_HUMAN	Decreases Expression	[14]
Carbohydrate sulfotransferase 4 (CHST4)	OTESMIW5	CHST4_HUMAN	Increases Expression	[14]
Potassium voltage-gated channel subfamily H member 5 (KCNH5)	OTVAHEAQ	KCNH5_HUMAN	Decreases Expression	[14]
Protein FAM13C (FAM13C)	OTVAGUOV	FA13C_HUMAN	Increases Expression	[14]
Zinc finger protein GLIS3 (GLIS3)	OTBC960E	GLIS3_HUMAN	Decreases Expression	[14]
Neuron navigator 1 (NAV1)	OT667KTL	NAV1_HUMAN	Decreases Expression	[14]
Nesprin-1 (SYNE1)	OTSBSLUH	SYNE1_HUMAN	Increases Expression	[14]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7)	OT8UTTXF	B3GN7_HUMAN	Increases Expression	[14]
Interleukin-17 receptor D (IL17RD)	OTKD9XST	I17RD_HUMAN	Decreases Expression	[14]
Bestrophin-4 (BEST4)	OT6S406I	BEST4_HUMAN	Decreases Expression	[14]
Semaphorin-6D (SEMA6D)	OTU0UAZS	SEM6D_HUMAN	Decreases Expression	[14]
Cell adhesion molecule 4 (CADM4)	OT0TFMFE	CADM4_HUMAN	Decreases Expression	[14]
Nuclear receptor coactivator 7 (NCOA7)	OT2CNBOG	NCOA7_HUMAN	Decreases Expression	[14]
LIM domain only protein 3 (LMO3)	OTR7AJHN	LMO3_HUMAN	Decreases Expression	[14]
Fibroblast growth factor-binding protein 3 (FGFBP3)	OTWM1KCM	FGFP3_HUMAN	Increases Expression	[14]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[14]
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (HMGCLL1)	OT9SQ5PU	HMGC2_HUMAN	Decreases Expression	[14]
E3 ubiquitin-protein ligase LNX (LNX1)	OTZWFMAZ	LNX1_HUMAN	Increases Expression	[14]
Synaptoporin (SYNPR)	OTNCJ9L0	SYNPR_HUMAN	Increases Expression	[14]
Fez family zinc finger protein 2 (FEZF2)	OTU4TXIW	FEZF2_HUMAN	Decreases Expression	[14]
Transmembrane protein 163 (TMEM163)	OTCT1Y1L	TM163_HUMAN	Decreases Expression	[14]
E3 ubiquitin-protein ligase RNF217 (RNF217)	OTAX91ES	RN217_HUMAN	Increases Expression	[14]
Fibronectin type 3 and ankyrin repeat domains protein 1 (FANK1)	OT5641YJ	FANK1_HUMAN	Decreases Expression	[14]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)	OTUTPVA9	PREX1_HUMAN	Increases Expression	[14]
Mucolipin-3 (MCOLN3)	OTCRPRVS	MCLN3_HUMAN	Increases Expression	[14]
Protocadherin Fat 3 (FAT3)	OT3C6H8W	FAT3_HUMAN	Decreases Expression	[14]
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15)	OTYB6JS3	ATS15_HUMAN	Increases Expression	[14]
A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAMTS19)	OTEG5Q2G	ATS19_HUMAN	Increases Expression	[14]
Grainyhead-like protein 3 homolog (GRHL3)	OT1V4ZEH	GRHL3_HUMAN	Increases Expression	[14]
Actin filament-associated protein 1-like 1 (AFAP1L1)	OTWNTNDB	AF1L1_HUMAN	Increases Expression	[14]
DENN domain-containing protein 1A (DENND1A)	OTONDAA0	DEN1A_HUMAN	Decreases Expression	[14]
Serine/threonine-protein kinase 32A (STK32A)	OTONYLYO	ST32A_HUMAN	Decreases Expression	[14]
RelA-associated inhibitor (PPP1R13L)	OTNCPLWE	IASPP_HUMAN	Increases Expression	[14]
Protein prune homolog 2 (PRUNE2)	OTGW2974	PRUN2_HUMAN	Decreases Expression	[14]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[14]
DDB1- and CUL4-associated factor 4 (DCAF4)	OTQU0EUO	DCAF4_HUMAN	Increases Expression	[14]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[14]
PH-interacting protein (PHIP)	OTZY806Z	PHIP_HUMAN	Decreases Expression	[14]
Cholesterol transporter ABCA5 (ABCA5)	OT4B9D92	ABCA5_HUMAN	Decreases Expression	[14]
Secretogranin-3 (SCG3)	OTUYSV2S	SCG3_HUMAN	Increases Expression	[14]
Adhesion G-protein coupled receptor V1 (ADGRV1)	OTLVXHHP	AGRV1_HUMAN	Decreases Expression	[14]
Connector enhancer of kinase suppressor of ras 2 (CNKSR2)	OTAGERJ2	CNKR2_HUMAN	Decreases Expression	[14]
BRI3-binding protein (BRI3BP)	OTWCFPRM	BRI3B_HUMAN	Increases Expression	[14]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Decreases Expression	[14]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Increases Expression	[14]
Jun dimerization protein 2 (JDP2)	OTW35WKX	JDP2_HUMAN	Increases Expression	[14]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)	OTBXYFRH	ARAP2_HUMAN	Increases Expression	[14]
Transcription factor AP-2-beta (TFAP2B)	OTR1T8E9	AP2B_HUMAN	Increases Expression	[14]
Protein FAM168A (FAM168A)	OTDXQCS5	F168A_HUMAN	Decreases Expression	[14]
Transcription factor AP-2 gamma (TFAP2C)	OTUDIW05	AP2C_HUMAN	Increases Expression	[14]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Decreases Expression	[14]
Ras-responsive element-binding protein 1 (RREB1)	OT62460U	RREB1_HUMAN	Increases Expression	[14]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Increases Expression	[14]
Coronin-2A (CORO2A)	OTVK7PK3	COR2A_HUMAN	Increases Expression	[14]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Decreases Expression	[14]
Protein kinase C-binding protein NELL1 (NELL1)	OTF3TX3N	NELL1_HUMAN	Increases Expression	[14]
Kinesin-associated protein 3 (KIFAP3)	OT450PAO	KIFA3_HUMAN	Increases Expression	[14]
BLOC-3 complex member HPS1 (HPS1)	OTKS5I7T	HPS1_HUMAN	Increases Expression	[14]
Deleted in azoospermia-like (DAZL)	OTZMTD4R	DAZL_HUMAN	Decreases Expression	[14]
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2)	OTL6SH28	PTPR2_HUMAN	Decreases Expression	[14]
Stathmin-2 (STMN2)	OT0FUHLH	STMN2_HUMAN	Increases Expression	[14]
Protein naked cuticle homolog 1 (NKD1)	OTY3MO97	NKD1_HUMAN	Increases Expression	[14]
Protein TMEPAI (PMEPA1)	OTY8Z9UF	PMEPA_HUMAN	Increases Expression	[14]
Mitochondrial amidoxime reducing component 2 (MTARC2)	OT8B6LVD	MARC2_HUMAN	Increases Expression	[14]
Terminal nucleotidyltransferase 5B (TENT5B)	OTO2P28B	TET5B_HUMAN	Increases Expression	[14]
Copine-4 (CPNE4)	OTTAGM5L	CPNE4_HUMAN	Increases Expression	[14]
SPRY domain-containing SOCS box protein 4 (SPSB4)	OTG9MLO4	SPSB4_HUMAN	Increases Expression	[14]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[14]
Ras-related protein Rab-7b (RAB7B)	OT60A0E9	RAB7B_HUMAN	Increases Expression	[14]
Transmembrane protein 125 (TMEM125)	OTWF8MC1	TM125_HUMAN	Increases Expression	[14]
Claudin-23 (CLDN23)	OTN5RV40	CLD23_HUMAN	Increases Expression	[14]
Transmembrane protein 18 (TMEM18)	OT05YQ1E	TMM18_HUMAN	Decreases Expression	[14]
Repulsive guidance molecule A (RGMA)	OTZAMDO2	RGMA_HUMAN	Decreases Expression	[14]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1)	OTIUA60B	SH3K1_HUMAN	Increases Expression	[14]
Serine/threonine-protein kinase Sgk3 (SGK3)	OTQ6QO99	SGK3_HUMAN	Increases Expression	[14]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Increases Expression	[14]
Endoplasmic reticulum resident protein 27 (ERP27)	OTVMGE2H	ERP27_HUMAN	Increases Expression	[14]
Polyadenylate-binding protein 5 (PABPC5)	OTLUTQ02	PABP5_HUMAN	Increases Expression	[14]
Ras-related protein Rab-3C (RAB3C)	OTFTJNGA	RAB3C_HUMAN	Increases Expression	[14]
Elongator complex protein 4 (ELP4)	OTP5GZ9V	ELP4_HUMAN	Decreases Expression	[14]
Multivesicular body subunit 12A (MVB12A)	OT3737K0	MB12A_HUMAN	Decreases Expression	[14]
CB1 cannabinoid receptor-interacting protein 1 (CNRIP1)	OTXPWJ56	CNRP1_HUMAN	Increases Expression	[14]
Protein FAM89A (FAM89A)	OTNASAXT	FA89A_HUMAN	Increases Expression	[14]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Decreases Expression	[14]
Transmembrane protein 169 (TMEM169)	OTKXDYVC	TM169_HUMAN	Decreases Expression	[14]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL)	OTW7D1SV	HPDL_HUMAN	Increases Expression	[14]
Epithelial-stromal interaction protein 1 (EPSTI1)	OT75I1UH	ESIP1_HUMAN	Increases Expression	[14]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1)	OTY5HZN5	LRIG1_HUMAN	Decreases Expression	[14]
Microtubule-associated protein 6 (MAP6)	OTPUI00F	MAP6_HUMAN	Decreases Expression	[14]
Coiled-coil domain-containing protein 136 (CCDC136)	OTPOV391	CC136_HUMAN	Decreases Expression	[14]
Golgi-associated RAB2 interactor protein 1B (GARIN1B)	OTWPN527	GAR1B_HUMAN	Decreases Expression	[14]
Phospholipase A and acyltransferase 5 (PLAAT5)	OT9JFFO2	PLAT5_HUMAN	Increases Expression	[14]
Sushi domain-containing protein 3 (SUSD3)	OTERJTUL	SUSD3_HUMAN	Increases Expression	[14]
Guanine nucleotide exchange factor C9orf72 (C9ORF72)	OT0WH38E	CI072_HUMAN	Decreases Expression	[14]
Kremen protein 1 (KREMEN1)	OTGJFSAC	KREM1_HUMAN	Increases Expression	[14]
Transmembrane protein 74 (TMEM74)	OT3IZBM0	TMM74_HUMAN	Decreases Expression	[14]
TOX high mobility group box family member 2 (TOX2)	OT7RZRVK	TOX2_HUMAN	Decreases Expression	[14]
Patched domain-containing protein 1 (PTCHD1)	OTFDLU5S	PTHD1_HUMAN	Increases Expression	[14]
Dachshund homolog 2 (DACH2)	OT33KEUZ	DACH2_HUMAN	Increases Expression	[14]
Chloride intracellular channel protein 6 (CLIC6)	OTFMSU5U	CLIC6_HUMAN	Increases Expression	[14]
Noelin-3 (OLFM3)	OTBHPDTL	NOE3_HUMAN	Increases Expression	[14]
Leucine-rich repeat-containing protein 3B (LRRC3B)	OT9VDGPR	LRC3B_HUMAN	Decreases Expression	[14]
Secretoglobin family 3A member 2 (SCGB3A2)	OTB63PHR	SG3A2_HUMAN	Increases Expression	[14]
VPS10 domain-containing receptor SorCS2 (SORCS2)	OTBF3DYK	SORC2_HUMAN	Decreases Expression	[14]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Increases Expression	[14]
DEP domain-containing protein 7 (DEPDC7)	OT62C942	DEPD7_HUMAN	Increases Expression	[14]
Rab-3A-interacting protein (RAB3IP)	OT3UPQAA	RAB3I_HUMAN	Decreases Expression	[14]
Homeobox protein ARX (ARX)	OTBGYH25	ARX_HUMAN	Decreases Expression	[14]
Lipase maturation factor 1 (LMF1)	OTOL14ZD	LMF1_HUMAN	Increases Expression	[14]
Doublesex- and mab-3-related transcription factor A2 (DMRTA2)	OTWQR1M7	DMTA2_HUMAN	Increases Expression	[14]
Mucin-4 (MUC4)	OTLT11V1	MUC4_HUMAN	Increases Expression	[14]
Glutamate decarboxylase 1 (GAD1)	OT52Z39J	DCE1_HUMAN	Increases Expression	[14]
Protein kinase C-binding protein NELL2 (NELL2)	OTS4MJZ7	NELL2_HUMAN	Decreases Expression	[14]
Sphingosine 1-phosphate receptor 3 (S1PR3)	OTXBIYO8	S1PR3_HUMAN	Decreases Expression	[14]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[14]
Fasciculation and elongation protein zeta-1 (FEZ1)	OTWCXPRE	FEZ1_HUMAN	Decreases Expression	[14]
Pituitary homeobox 2 (PITX2)	OTWMXAOY	PITX2_HUMAN	Increases Expression	[14]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[14]
Epidermal growth factor-like protein 8 (EGFL8)	OTECTJ7K	EGFL8_HUMAN	Increases Expression	[14]
Forkhead box protein C2 (FOXC2)	OT83P1E0	FOXC2_HUMAN	Increases Expression	[14]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Increases Expression	[14]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Increases Expression	[14]
Semaphorin-3C (SEMA3C)	OTEGUY7F	SEM3C_HUMAN	Increases Expression	[14]
Fermitin family homolog 1 (FERMT1)	OT626PBA	FERM1_HUMAN	Increases Expression	[14]
Synaptotagmin-11 (SYT11)	OTLRTZEI	SYT11_HUMAN	Decreases Expression	[14]
Brain-enriched guanylate kinase-associated protein (BEGAIN)	OTT3UD2K	BEGIN_HUMAN	Decreases Expression	[14]
Protein ABHD14A (ABHD14A)	OT94GKE1	ABHEA_HUMAN	Decreases Expression	[14]
Ribonuclease P protein subunit p25 (RPP25)	OTEN6QN7	RPP25_HUMAN	Increases Expression	[14]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[14]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5)	OTH91ETM	SIA7E_HUMAN	Decreases Expression	[14]
Cell cycle regulator of non-homologous end joining (CYREN)	OT5ZL00R	CYREN_HUMAN	Decreases Expression	[14]
Brother of CDO (BOC)	OTXBCY9W	BOC_HUMAN	Increases Expression	[14]
RNA-binding protein 24 (RBM24)	OTQI1AR1	RBM24_HUMAN	Decreases Expression	[14]
Receptor for retinol uptake STRA6 (STRA6)	OT2IDF27	STRA6_HUMAN	Increases Expression	[14]
Sphingosine-1-phosphate phosphatase 1 (SGPP1)	OT9X54CQ	SGPP1_HUMAN	Increases Expression	[14]
Sal-like protein 3 (SALL3)	OTJ2LZKQ	SALL3_HUMAN	Decreases Expression	[14]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Increases Expression	[14]
Complement C1q tumor necrosis factor-related protein 4 (C1QTNF4)	OTHD4Y9D	C1QT4_HUMAN	Decreases Expression	[14]
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C)	OTM4ECDK	MLP3C_HUMAN	Increases Expression	[14]
R-spondin-3 (RSPO3)	OTZK8GDS	RSPO3_HUMAN	Increases Expression	[14]
Histone deacetylase 8 (HDAC8)	OT5L4RYX	HDAC8_HUMAN	Increases Expression	[14]
Dedicator of cytokinesis protein 9 (DOCK9)	OT84H8AD	DOCK9_HUMAN	Increases Expression	[14]
Iroquois-class homeodomain protein IRX-2 (IRX2)	OTBHXXQ2	IRX2_HUMAN	Increases Expression	[14]
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2)	OT5JLP2H	NMNA2_HUMAN	Increases Expression	[14]
Thiamine transporter 2 (SLC19A3)	OTOWP1CT	S19A3_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase TRIM9 (TRIM9)	OTKYG33W	TRIM9_HUMAN	Increases Expression	[14]
Tripartite motif-containing protein 6 (TRIM6)	OTBSMX0B	TRIM6_HUMAN	Increases Expression	[14]
Protein TANC1 (TANC1)	OTF6TZ8E	TANC1_HUMAN	Increases Expression	[14]
Ethanolaminephosphotransferase 1 (SELENOI)	OTX2A47A	EPT1_HUMAN	Increases Expression	[14]
SRC kinase signaling inhibitor 1 (SRCIN1)	OTQZNQQ5	SRCN1_HUMAN	Decreases Expression	[14]
Metal cation symporter ZIP8 (SLC39A8)	OT6C6MNV	S39A8_HUMAN	Increases Expression	[14]
Immortalization up-regulated protein (C19ORF33)	OTOYH74A	IMUP_HUMAN	Increases Expression	[14]
PR domain zinc finger protein 14 (PRDM14)	OTWZKY4L	PRD14_HUMAN	Increases Expression	[14]
NUAK family SNF1-like kinase 2 (NUAK2)	OTUEZLO8	NUAK2_HUMAN	Decreases Expression	[14]
CYFIP-related Rac1 interactor A (CYRIA)	OT2VJ767	CYRIA_HUMAN	Increases Expression	[14]
Ras-related protein Rab-17 (RAB17)	OT7NBUGQ	RAB17_HUMAN	Increases Expression	[14]
B-cell lymphoma/leukemia 11A (BCL11A)	OTI6ZBP6	BC11A_HUMAN	Increases Expression	[14]
Kinesin-like protein KIF13A (KIF13A)	OTSSZGBQ	KI13A_HUMAN	Decreases Expression	[14]
Sphingosine 1-phosphate receptor 5 (S1PR5)	OTQF1R0U	S1PR5_HUMAN	Increases Expression	[14]
Synaptotagmin-4 (SYT4)	OTA1D7VL	SYT4_HUMAN	Increases Expression	[14]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)	OT38HXJP	CRLD1_HUMAN	Increases Expression	[14]
Sorting nexin-25 (SNX25)	OT8JY8M1	SNX25_HUMAN	Decreases Expression	[14]
Leucine-rich repeat neuronal protein 3 (LRRN3)	OT7X0AA7	LRRN3_HUMAN	Increases Expression	[14]
Calsyntenin-2 (CLSTN2)	OT2PJYHX	CSTN2_HUMAN	Increases Expression	[14]
SPARC-related modular calcium-binding protein 1 (SMOC1)	OTJG2JQY	SMOC1_HUMAN	Decreases Expression	[14]
DNA transposase THAP9 (THAP9)	OTY4TSJO	THAP9_HUMAN	Decreases Expression	[14]
SLIT and NTRK-like protein 6 (SLITRK6)	OTLNWI5G	SLIK6_HUMAN	Increases Expression	[14]
Epithelial splicing regulatory protein 2 (ESRP2)	OTVTKJ4I	ESRP2_HUMAN	Increases Expression	[14]
Dedicator of cytokinesis protein 5 (DOCK5)	OT63I0CL	DOCK5_HUMAN	Increases Expression	[14]
NIPA-like protein 2 (NIPAL2)	OTX9UREP	NPAL2_HUMAN	Increases Expression	[14]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (MTHFD2L)	OTDYNXRG	MTD2L_HUMAN	Increases Expression	[14]
Nuclear body protein SP140-like protein (SP140L)	OTL30JKT	SP14L_HUMAN	Increases Expression	[14]
Chondrolectin (CHODL)	OTVCNOUQ	CHODL_HUMAN	Increases Expression	[14]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[14]
Adhesion G protein-coupled receptor L3 (ADGRL3)	OT81Q8LY	AGRL3_HUMAN	Decreases Expression	[14]
Netrin-4 (NTN4)	OTDRRMP3	NET4_HUMAN	Decreases Expression	[14]
V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4)	OT149Z7Q	VPP4_HUMAN	Increases Expression	[14]
Collectrin (CLTRN)	OTXGFJ3F	CLTRN_HUMAN	Decreases Expression	[14]
Ethanolamine kinase 1 (ETNK1)	OTDKB4DQ	EKI1_HUMAN	Increases Expression	[14]
Popeye domain-containing protein 3 (POPDC3)	OTN4FJ5J	POPD3_HUMAN	Decreases Expression	[14]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)	OTAQD3YV	ARNT2_HUMAN	Decreases Expression	[14]
Prokineticin-2 (PROK2)	OT70IFEZ	PROK2_HUMAN	Decreases Expression	[14]
Sodium/potassium/calcium exchanger 3 (SLC24A3)	OTEJN38N	NCKX3_HUMAN	Increases Expression	[14]
Mineralization regulator ANKH (ANKH)	OTCN25R5	ANKH_HUMAN	Increases Expression	[14]
UPF0606 protein KIAA1549 (KIAA1549)	OTA5B18F	K1549_HUMAN	Decreases Expression	[14]
Band 4.1-like protein 5 (EPB41L5)	OTPPQPLU	E41L5_HUMAN	Increases Expression	[14]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[14]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Increases Expression	[14]
Mid1-interacting protein 1 (MID1IP1)	OTFCORJM	M1IP1_HUMAN	Increases Expression	[14]
Frizzled-3 (FZD3)	OTIWDN78	FZD3_HUMAN	Decreases Expression	[14]
Nuclear receptor-interacting protein 3 (NRIP3)	OTU15GMK	NRIP3_HUMAN	Decreases Expression	[14]
Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2)	OT661S7D	SCUB2_HUMAN	Decreases Expression	[14]
Solute carrier family 52, riboflavin transporter, member 3 (SLC52A3)	OT1FHFMK	S52A3_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase Jade-2 (JADE2)	OTVG2MYF	JADE2_HUMAN	Increases Expression	[14]
Ras-related GTP-binding protein D (RRAGD)	OTXLVWAH	RRAGD_HUMAN	Decreases Expression	[14]
Coiled-coil domain-containing protein 177 (CCDC177)	OT44WWP5	CC177_HUMAN	Decreases Expression	[14]
Sialic acid synthase (NANS)	OTMQ2FUH	SIAS_HUMAN	Increases Expression	[14]
Platelet-derived growth factor C (PDGFC)	OT3ZJ0XU	PDGFC_HUMAN	Increases Expression	[14]
N-lysine methyltransferase SMYD2 (SMYD2)	OTN8035R	SMYD2_HUMAN	Increases Expression	[14]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)	OTWHOVZS	BAZ1A_HUMAN	Increases Expression	[14]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Increases Expression	[14]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1)	OT2ZSZ6P	C1GLT_HUMAN	Increases Expression	[14]
Glutaredoxin-2, mitochondrial (GLRX2)	OT4LIRBC	GLRX2_HUMAN	Increases Expression	[14]
Protein reprimo (RPRM)	OTNNBAS1	RPRM_HUMAN	Increases Expression	[14]
Probable G-protein coupled receptor 173 (GPR173)	OT8F8XR1	GP173_HUMAN	Decreases Expression	[14]
Probable G-protein coupled receptor 27 (GPR27)	OTH4KQPI	GPR27_HUMAN	Decreases Expression	[14]
Asc-type amino acid transporter 1 (SLC7A10)	OTN1S03Q	AAA1_HUMAN	Increases Expression	[14]
EMILIN-3 (EMILIN3)	OT2BZTSU	EMIL3_HUMAN	Decreases Expression	[14]
Teneurin-2 (TENM2)	OTPLUYEF	TEN2_HUMAN	Increases Expression	[14]
Obg-like ATPase 1 (OLA1)	OTAPOTTG	OLA1_HUMAN	Decreases Expression	[14]
Muscleblind-like protein 3 (MBNL3)	OT2T2YOK	MBNL3_HUMAN	Increases Expression	[14]
RNA binding protein fox-1 homolog 1 (RBFOX1)	OTFPKEL7	RFOX1_HUMAN	Increases Expression	[14]
Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB)	OTXLLSIZ	MCUB_HUMAN	Decreases Expression	[14]
Ras-related protein Rab-20 (RAB20)	OTP9OOVS	RAB20_HUMAN	Increases Expression	[14]
Very long chain fatty acid elongase 2 (ELOVL2)	OTDAF6U3	ELOV2_HUMAN	Decreases Expression	[14]
Sphingosine kinase 1 (SPHK1)	OTWYPBVD	SPHK1_HUMAN	Increases Expression	[14]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Increases Expression	[14]
Endoplasmic reticulum aminopeptidase 1 (ERAP1)	OT72S99B	ERAP1_HUMAN	Decreases Expression	[14]
Transcription factor CP2-like protein 1 (TFCP2L1)	OT7QIJ0X	TF2L1_HUMAN	Increases Expression	[14]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Increases Expression	[14]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)	OTW3T4B2	IRPL1_HUMAN	Decreases Expression	[14]
Tropomodulin-2 (TMOD2)	OTTTUH2W	TMOD2_HUMAN	Increases Expression	[14]
Potassium voltage-gated channel subfamily D member 2 (KCND2)	OTIFUVV7	KCND2_HUMAN	Decreases Expression	[14]
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)	OT452ZDC	ADA22_HUMAN	Decreases Expression	[14]
DOMON domain-containing protein FRRS1L (FRRS1L)	OT24ABVC	FRS1L_HUMAN	Decreases Expression	[14]
Peroxisomal sarcosine oxidase (PIPOX)	OTWTCOTN	SOX_HUMAN	Increases Expression	[14]
MyoD family inhibitor domain-containing protein (MDFIC)	OTSRYBWZ	MDFIC_HUMAN	Increases Expression	[14]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Increases Expression	[14]
Junctional cadherin 5-associated protein (JCAD)	OT7G1WJW	JCAD_HUMAN	Increases Expression	[14]
Protocadherin-10 (PCDH10)	OT2GIT0E	PCD10_HUMAN	Increases Expression	[14]
Kelch-like protein 14 (KLHL14)	OTYOS55H	KLH14_HUMAN	Increases Expression	[14]
Short transient receptor potential channel 4 (TRPC4)	OTYY9DPV	TRPC4_HUMAN	Decreases Expression	[14]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2)	OTU4J3ZI	HEY2_HUMAN	Increases Expression	[14]
Homeobox expressed in ES cells 1 (HESX1)	OT5E2Z4G	HESX1_HUMAN	Decreases Expression	[14]
Small conductance calcium-activated potassium channel protein 3 (KCNN3)	OT11KYA8	KCNN3_HUMAN	Decreases Expression	[14]
Testin (TES)	OTL8PP6V	TES_HUMAN	Increases Expression	[14]
Sushi domain-containing protein 2 (SUSD2)	OTSJTAZP	SUSD2_HUMAN	Increases Expression	[14]
Transcription factor COE1 (EBF1)	OTZ61YYH	COE1_HUMAN	Increases Expression	[14]
Zinc finger transcription factor Trps1 (TRPS1)	OT7XPPEL	TRPS1_HUMAN	Increases Expression	[14]
Scm-like with four MBT domains protein 1 (SFMBT1)	OTKMZIBW	SMBT1_HUMAN	Decreases Expression	[14]
Krueppel-like factor 15 (KLF15)	OTGMQMVR	KLF15_HUMAN	Increases Expression	[14]
E3 ISG15--protein ligase HERC5 (HERC5)	OTZ5PR39	HERC5_HUMAN	Increases Expression	[14]
Potassium voltage-gated channel subfamily G member 1 (KCNG1)	OTZ9ZRG8	KCNG1_HUMAN	Increases Expression	[14]
Forkhead box protein D3 (FOXD3)	OTXYV6GO	FOXD3_HUMAN	Increases Expression	[14]
Purine-rich element-binding protein gamma (PURG)	OTXPQDWN	PURG_HUMAN	Decreases Expression	[14]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (GNG8)	OT9YHSF1	GBG8_HUMAN	Decreases Expression	[14]
F-box only protein 2 (FBXO2)	OTF3677S	FBX2_HUMAN	Increases Expression	[14]
Ribosomal protein S6 kinase alpha-6 (RPS6KA6)	OTTY0FI2	KS6A6_HUMAN	Decreases Expression	[14]
Nocturnin (NOCT)	OTVSYP2D	NOCT_HUMAN	Increases Expression	[14]
Adherens junction-associated protein 1 (AJAP1)	OTAAW121	AJAP1_HUMAN	Increases Expression	[14]
TRAF2 and NCK-interacting protein kinase (TNIK)	OTDZBJ4K	TNIK_HUMAN	Increases Expression	[14]
Cdc42 effector protein 3 (CDC42EP3)	OTUZ3U9Z	BORG2_HUMAN	Decreases Expression	[14]
Disintegrin and metalloproteinase domain-containing protein 28 (ADAM28)	OT3GBVHL	ADA28_HUMAN	Increases Expression	[14]
ETS-related transcription factor Elf-5 (ELF5)	OTLRU8YF	ELF5_HUMAN	Increases Expression	[14]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2)	OTSUEQZ1	PCOC2_HUMAN	Increases Expression	[14]
DENN domain-containing protein 2A (DENND2A)	OT01E1PL	DEN2A_HUMAN	Decreases Expression	[14]
NACHT and WD repeat domain-containing protein 2 (NWD2)	OTN47UBK	NWD2_HUMAN	Increases Expression	[14]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Decreases Expression	[14]
Neurabin-1 (PPP1R9A)	OTJL2TOC	NEB1_HUMAN	Decreases Expression	[14]
RING finger protein 150 (RNF150)	OTAMSBK5	RN150_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase CBL-C (CBLC)	OT3RKZI9	CBLC_HUMAN	Increases Expression	[14]
Frizzled-10 (FZD10)	OTSAENLT	FZD10_HUMAN	Increases Expression	[14]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Increases Expression	[14]
Sex comb on midleg-like protein 1 (SCML1)	OT7V5DAR	SCML1_HUMAN	Increases Expression	[14]
DNA polymerase iota (POLI)	OTBA4DCE	POLI_HUMAN	Decreases Expression	[14]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Decreases Expression	[14]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Increases Expression	[14]
Catenin delta-2 (CTNND2)	OTYKE30Y	CTND2_HUMAN	Decreases Expression	[14]
Tenascin-N (TNN)	OTQK2AMX	TENN_HUMAN	Increases Expression	[14]
Short transient receptor potential channel 6 (TRPC6)	OT5J7HVM	TRPC6_HUMAN	Increases Expression	[14]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9)	OTLIJBQY	FUT9_HUMAN	Decreases Expression	[14]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)	OT74EK7Z	PDE10_HUMAN	Decreases Expression	[14]
Leucine zipper putative tumor suppressor 1 (LZTS1)	OTXXL864	LZTS1_HUMAN	Increases Expression	[14]
C-C motif chemokine 26 (CCL26)	OT2B7HR9	CCL26_HUMAN	Increases Expression	[14]
TBC1 domain family member 30 (TBC1D30)	OTG8HGSI	TBC30_HUMAN	Decreases Expression	[14]
Band 4.1-like protein 3 (EPB41L3)	OTS6CHG2	E41L3_HUMAN	Increases Expression	[14]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Increases Expression	[14]
Retinal homeobox protein Rx (RAX)	OTJ3YCE7	RX_HUMAN	Decreases Expression	[14]
Tudor and KH domain-containing protein (TDRKH)	OTV21BN1	TDRKH_HUMAN	Decreases Expression	[14]
Transmembrane emp24 domain-containing protein 5 (TMED5)	OT70W1J8	TMED5_HUMAN	Increases Expression	[14]
C2 domain-containing protein 2 (C2CD2)	OTL1K0OB	C2CD2_HUMAN	Decreases Expression	[14]
Sal-like protein 2 (SALL2)	OTQWI68Q	SALL2_HUMAN	Decreases Expression	[14]
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2)	OTJBDX0Y	VPP2_HUMAN	Decreases Expression	[14]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Increases Expression	[14]
Transcription factor HES-2 (HES2)	OTMWY2KV	HES2_HUMAN	Increases Expression	[14]
Intraflagellar transport protein 25 homolog (IFT25)	OTDR1HG6	IFT25_HUMAN	Decreases Expression	[14]
Low-density lipoprotein receptor-related protein 12 (LRP12)	OTRT1UJ7	LRP12_HUMAN	Decreases Expression	[14]
Protein mab-21-like 2 (MAB21L2)	OTZM5VMX	MB212_HUMAN	Decreases Expression	[14]
Protocadherin beta-14 (PCDHB14)	OTFZF1ST	PCDBE_HUMAN	Decreases Expression	[14]
Transcription factor MafB (MAFB)	OTH2N3T8	MAFB_HUMAN	Increases Expression	[14]
Neuropeptide FF receptor 2 (NPFFR2)	OTVI4Q85	NPFF2_HUMAN	Increases Expression	[14]
Beta-secretase 2 (BACE2)	OTO5YQVK	BACE2_HUMAN	Increases Expression	[14]
Glypican-6 (GPC6)	OTNJBESF	GPC6_HUMAN	Decreases Expression	[14]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Decreases Expression	[14]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)	OTK53GUD	HS3SB_HUMAN	Decreases Expression	[14]
LHFPL tetraspan subfamily member 6 protein (LHFPL6)	OTY6LHJY	LHPL6_HUMAN	Increases Expression	[14]
Mitochondrial inner membrane protease ATP23 homolog (ATP23)	OT303R2T	ATP23_HUMAN	Increases Expression	[14]
Gap junction alpha-3 protein (GJA3)	OTXV6ETF	CXA3_HUMAN	Increases Expression	[14]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR)	OTTLD0KB	SQOR_HUMAN	Increases Expression	[14]
Cadherin-10 (CDH10)	OTK3D5WP	CAD10_HUMAN	Increases Expression	[14]
Calpain-6 (CAPN6)	OT8K5PR5	CAN6_HUMAN	Decreases Expression	[14]
AP-1 complex subunit mu-2 (AP1M2)	OTUE5YLC	AP1M2_HUMAN	Increases Expression	[14]
Dual specificity protein phosphatase 10 (DUSP10)	OTNG467B	DUS10_HUMAN	Increases Expression	[14]
Collagen alpha-1(XI) chain (COL11A1)	OTB0DRMS	COBA1_HUMAN	Increases Expression	[21]
Neuronal growth regulator 1 (NEGR1)	OT57ECW9	NEGR1_HUMAN	Increases Expression	[21]
Bone morphogenetic protein receptor type-1B (BMPR1B)	OTGFN0OD	BMR1B_HUMAN	Affects Expression	[16]
Huntingtin-interacting protein 1 (HIP1)	OT7AKCFQ	HIP1_HUMAN	Increases Expression	[15]
Homeobox protein Meis2 (MEIS2)	OTG4ADLM	MEIS2_HUMAN	Affects Expression	[16]
T-box transcription factor TBX3 (TBX3)	OTM64N7K	TBX3_HUMAN	Affects Expression	[16]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[22]
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (ST8SIA3)	OTG9MXV9	SIA8C_HUMAN	Affects Expression	[16]
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)	OTX1C2GS	DYRK3_HUMAN	Increases Expression	[15]
Transmembrane and coiled-coil domains protein 2 (TMCC2)	OT0D7IYD	TMCC2_HUMAN	Increases Expression	[15]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Increases Expression	[23]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Acetylation	[23]
Nuclear factor 1 C-type (NFIC)	OTLMCUIB	NFIC_HUMAN	Affects Expression	[16]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Increases Expression	[15]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[24]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[23]
Interleukin-3 receptor subunit alpha (IL3RA)	OTDC3Y8O	IL3RA_HUMAN	Increases Expression	[15]
G-protein coupled receptor 183 (GPR183)	OTRILX7G	GP183_HUMAN	Decreases Expression	[15]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[25]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases Acetylation	[26]
OX-2 membrane glycoprotein (CD200)	OTQEQSRT	OX2G_HUMAN	Affects Expression	[16]
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9)	OTNAR1I2	PTN9_HUMAN	Affects Expression	[16]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[25]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Decreases Expression	[22]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Increases Acetylation	[27]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)	OTPTCBUN	GCYA1_HUMAN	Affects Expression	[16]
Unconventional myosin-Ie (MYO1E)	OTM9YSIZ	MYO1E_HUMAN	Increases Expression	[15]
Cyclin-dependent kinase 5 activator 1 (CDK5R1)	OTJELWK0	CD5R1_HUMAN	Decreases Expression	[15]
Histone H3.1t (H3-4)	OTY6ITYF	H31T_HUMAN	Increases Acetylation	[27]
Rho GTPase-activating protein 31 (ARHGAP31)	OTUYTF4I	RHG31_HUMAN	Affects Expression	[16]
Fidgetin (FIGN)	OTJF6EZR	FIGN_HUMAN	Affects Expression	[16]
NHS-like protein 2 (NHSL2)	OT8U1P8E	NHSL2_HUMAN	Affects Expression	[16]
Failed axon connections homolog (FAXC)	OTU0RGB0	FAXC_HUMAN	Affects Expression	[16]
AT-rich interactive domain-containing protein 2 (ARID2)	OTIRJXWM	ARID2_HUMAN	Affects Expression	[16]
Male-specific lethal 1 homolog (MSL1)	OTXLFYLB	MSL1_HUMAN	Decreases Expression	[15]
Rab11 family-interacting protein 1 (RAB11FIP1)	OT0T71OW	RFIP1_HUMAN	Increases Expression	[15]
Protein lin-28 homolog B (LIN28B)	OTVWP0FN	LN28B_HUMAN	Decreases Expression	[16]
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1)	OTKI3IU9	LRRT1_HUMAN	Affects Expression	[16]
Transforming growth factor beta activator LRRC33 (NRROS)	OT9WNOKY	LRC33_HUMAN	Decreases Expression	[15]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)	OT95QT6P	DTWD1_HUMAN	Decreases Expression	[15]
TBC1 domain family member 16 (TBC1D16)	OTPR3C6A	TBC16_HUMAN	Increases Expression	[15]
Transforming growth factor-beta receptor-associated protein 1 (TGFBRAP1)	OT80QNR5	TGFA1_HUMAN	Affects Expression	[16]
Alpha-2,8-sialyltransferase 8B (ST8SIA2)	OTRBBBD8	SIA8B_HUMAN	Affects Expression	[16]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Affects Expression	[16]
Protein Jumonji (JARID2)	OT14UM8H	JARD2_HUMAN	Increases Expression	[15]
ELL-associated factor 2 (EAF2)	OTSOET5L	EAF2_HUMAN	Increases Expression	[15]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Increases Expression	[15]
Protein FAM163A (FAM163A)	OT0MYZ0F	F163A_HUMAN	Affects Expression	[16]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Increases Expression	[15]
Small integral membrane protein 14 (SMIM14)	OT47IF19	SIM14_HUMAN	Increases Expression	[15]
Sialidase-1 (NEU1)	OTH9BY8Y	NEUR1_HUMAN	Increases Expression	[15]
Partner of Y14 and mago (PYM1)	OTEZ2WUO	PYM1_HUMAN	Decreases Expression	[15]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)	OTM3B3OA	TBL1R_HUMAN	Affects Expression	[16]
E3 ubiquitin-protein ligase TRIM8 (TRIM8)	OTS6JFR0	TRIM8_HUMAN	Affects Expression	[16]
Sentrin-specific protease 6 (SENP6)	OT05LLF4	SENP6_HUMAN	Affects Expression	[16]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Increases Expression	[28]
Popeye domain-containing protein 2 (POPDC2)	OTDAZSY5	POPD2_HUMAN	Affects Expression	[16]
F-box only protein 8 (FBXO8)	OTZNGJGW	FBX8_HUMAN	Affects Expression	[16]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Increases Expression	[15]
AP-5 complex subunit sigma-1 (AP5S1)	OTGS53SC	AP5S1_HUMAN	Decreases Expression	[15]
Pre-mRNA-splicing factor RBM22 (RBM22)	OTFW0IGK	RBM22_HUMAN	Decreases Expression	[15]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)	OTY6ZHVA	RGL1_HUMAN	Increases Expression	[15]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Increases Expression	[26]
Coiled-coil and C2 domain-containing protein 2A (CC2D2A)	OTFGRGFR	C2D2A_HUMAN	Affects Expression	[16]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Decreases Expression	[22]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)	OT27CCUF	SIAT9_HUMAN	Increases Expression	[15]
RING finger protein 24 (RNF24)	OTUZI597	RNF24_HUMAN	Increases Expression	[15]
Phosphatidylinositide phosphatase SAC2 (INPP5F)	OTPKUY50	SAC2_HUMAN	Increases Expression	[15]
DmX-like protein 1 (DMXL1)	OTWVL31L	DMXL1_HUMAN	Increases Expression	[15]
Cystathionine beta-synthase (CBS)	OT46FSKD	CBS_HUMAN	Increases ADR	[29]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)	OT53SIZG	NAA15_HUMAN	Increases ADR	[29]
Methylenetetrahydrofolate reductase (MTHFR)	OTUBJSR7	MTHR_HUMAN	Increases ADR	[29]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Ewing sarcoma	DC3OO65	TC-71	Investigative	[1]

References

• [1] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [2] ClinicalTrials.gov (NCT04472598) Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis (TRANSFORM-1). U.S. National Institutes of Health.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8319).
• [4] Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50.
• [5] Panobinostat FDA Label
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7489).
• [8] Clinical pipeline report, company report or official report of Roche (2009).
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9.
• [11] Effect of rifampin on the pharmacokinetics, safety and tolerability of navitoclax (ABT-263), a dual inhibitor of Bcl-2 and Bcl-XL , in patients with cancer. J Clin Pharm Ther. 2014 Dec;39(6):680-4.
• [12] Human breast cancer cells display different sensitivities to ABT-263 based on the level of survivin. Toxicol In Vitro. 2018 Feb;46:229-236. doi: 10.1016/j.tiv.2017.09.023. Epub 2017 Sep 23.
• [13] BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation. Blood. 2011 Jun 30;117(26):7145-54. doi: 10.1182/blood-2011-03-344812. Epub 2011 May 11.
• [14] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [15] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [16] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [17] Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32.
• [18] Panobinostat for the treatment of multiple myeloma: the evidence to date. J Blood Med. 2015 Oct 8;6:269-76.
• [19] Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes. Expert Rev Clin Pharmacol. 2016;9(1):35-48.
• [20] Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
• [21] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [22] Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
• [23] SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May 16;4(5):e635. doi: 10.1038/cddis.2013.159.
• [24] Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway. Mol Pharmacol. 2012 Dec;82(6):1030-41. doi: 10.1124/mol.112.079624. Epub 2012 Aug 24.
• [25] Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro Oncol. 2008 Jun;10(3):309-19. doi: 10.1215/15228517-2007-063. Epub 2008 Apr 29.
• [26] Essential role of HDAC6 in the regulation of PD-L1 in?melanoma. Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.
• [27] A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):904-12. doi: 10.1016/j.ijrobp.2008.10.032.
• [28] Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
• [29] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.