Details of the Drug Combination

General Information of Drug Combination (ID: DCOCGKP)

Drug Combination Name
Trifluridine Dactinomycin
Indication
Disease Entry Status REF
Large cell lung carcinoma Investigative [1]
Component Drugs Trifluridine   DMG2YBD Dactinomycin   DM2YGNW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: NCI-H460
Zero Interaction Potency (ZIP) Score: 4.86
Bliss Independence Score: 7.04
Loewe Additivity Score: 5.14
LHighest Single Agent (HSA) Score: 6.34

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Trifluridine
Disease Entry ICD 11 Status REF
Herpetic keratitis 1F00.10 Approved [2]
Virus infection 1A24-1D9Z Approved [3]
Colon cancer 2B90.Z Investigative [2]
Trifluridine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [6]
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Trifluridine Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [7]
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [8]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [8]
Equilibrative nucleoside transporter 2 (SLC29A2) DTW78DQ S29A2_HUMAN Substrate [8]
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Trifluridine Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Thymidine phosphorylase (TYMP) DE4HCYL TYPH_HUMAN Metabolism [9]
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Trifluridine Interacts with 7 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [10]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [11]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Cleavage [12]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [12]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Cleavage [12]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [12]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Activity [13]
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⏷ Show the Full List of 7 DOT(s)
Indication(s) of Dactinomycin
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [4]
Advanced cancer 2A00-2F9Z Approved [4]
Beckwith-Wiedemann syndrome N.A. Approved [4]
Childhood kidney Wilms tumor N.A. Approved [4]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [4]
Hamartoma N.A. Approved [4]
Solid tumour/cancer 2A00-2F9Z Approved [5]
Wilms tumor N.A. Approved [4]
Dactinomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [17]
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Dactinomycin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [18]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [19]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [20]
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Dactinomycin Interacts with 85 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [21]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [22]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [14]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [14]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [14]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [14]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [14]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [14]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [14]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [14]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [14]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [14]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [14]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [14]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [14]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [14]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [14]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [14]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [14]
Endonuclease III-like protein 1 (NTHL1) OTPQXPT1 NTH_HUMAN Decreases Expression [14]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [14]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [14]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [14]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [14]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [14]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [14]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [14]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [14]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [14]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [14]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [14]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [14]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [14]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [14]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [14]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [14]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [14]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [14]
Protein O-mannosyl-transferase 1 (POMT1) OTGQSHL5 POMT1_HUMAN Increases Expression [14]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [23]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [24]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [25]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [26]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [27]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [28]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [27]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [29]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [30]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [31]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [27]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [32]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [33]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [31]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [27]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [34]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [35]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [36]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [37]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [38]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [39]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [28]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [27]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [27]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [27]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [40]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [41]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [42]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [27]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [27]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [43]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [27]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Expression [27]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [44]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [45]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [46]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [27]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [27]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Degradation [47]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [27]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [37]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [34]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [48]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [28]
Hyaluronidase-1 (HYAL1) OT2SJN0X HYAL1_HUMAN Increases ADR [49]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [50]
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⏷ Show the Full List of 85 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DC3ES2Q HL-60(TB) Investigative [51]
Adult T acute lymphoblastic leukemia DCD6CY1 MOLT-4 Investigative [51]
Anaplastic large cell lymphoma DC3AY1B SR Investigative [51]
Astrocytoma DCQP057 SNB-19 Investigative [51]
Clear cell renal cell carcinoma DCRWKV8 786-0 Investigative [51]
Clear cell renal cell carcinoma DCAH70N TK-10 Investigative [51]
Glioblastoma DCDSXB3 SNB-75 Investigative [51]
Glioma DCKYSRL SF-295 Investigative [51]
Glioma DC7E7NX SF-268 Investigative [51]
Plasma cell myeloma DCT7RAJ RPMI-8226 Investigative [51]
Renal cell carcinoma DCY56W5 UO-31 Investigative [51]
Breast adenocarcinoma DCQJUG9 MDA-MB-468 Investigative [52]
Carcinoma DC9YU1L RXF 393 Investigative [52]
Carcinoma DCAL5N9 MCF7 Investigative [52]
Colon adenocarcinoma DC6WOMM COLO 205 Investigative [52]
Invasive ductal carcinoma DC3V6J8 T-47D Investigative [52]
Invasive ductal carcinoma DCFB3MA BT-549 Investigative [52]
Invasive ductal carcinoma DC9K1EX HS 578T Investigative [52]
Adenocarcinoma DCVJV33 HCT-15 Investigative [1]
Adenocarcinoma DC9X8UX HCT116 Investigative [1]
Adenocarcinoma DCD21RC SW-620 Investigative [1]
Cutaneous melanoma DC8028I SK-MEL-28 Investigative [1]
Cutaneous melanoma DCCUA30 SK-MEL-5 Investigative [1]
High grade ovarian serous adenocarcinoma DCE2PZ4 OVCAR-5 Investigative [1]
Lung adenocarcinoma DCGQBLD EKVX Investigative [1]
Lung adenocarcinoma DCEVL8U NCI-H522 Investigative [1]
Malignant melanoma DCKV2VV LOX IMVI Investigative [1]
Melanoma DCH8RBI SK-MEL-2 Investigative [1]
Melanoma DCM8FUJ MALME-3M Investigative [1]
Minimally invasive lung adenocarcinoma DC1GULX NCI-H322M Investigative [1]
Non-small cell lung carcinoma DCBG6V2 HOP-92 Investigative [1]
Prostate carcinoma DC1HPMR PC-3 Investigative [1]
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⏷ Show the Full List of 32 DrugCom(s)

References

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