Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTP9G5QB)

DOT Name Cathepsin B (CTSB)
Synonyms EC 3.4.22.1; APP secretase; APPS; Cathepsin B1
Gene Name CTSB
Related Disease
Keratolytic winter erythema ( )
UniProt ID
CATB_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1CSB; 1GMY; 1HUC; 1PBH; 2IPP; 2PBH; 3AI8; 3CBJ; 3CBK; 3K9M; 3PBH; 5MBL; 5MBM; 6AY2; 8B4T; 8B5F
EC Number
3.4.22.1
Pfam ID
PF00112 ; PF08127
Sequence
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.
Tissue Specificity Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.
KEGG Pathway
Autophagy - animal (hsa04140 )
Lysosome (hsa04142 )
Apoptosis (hsa04210 )
Antigen processing and presentation (hsa04612 )
NOD-like receptor sig.ling pathway (hsa04621 )
Renin secretion (hsa04924 )
Reactome Pathway
Trafficking and processing of endosomal TLR (R-HSA-1679131 )
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090 )
MHC class II antigen presentation (R-HSA-2132295 )
Neutrophil degranulation (R-HSA-6798695 )
Collagen degradation (R-HSA-1442490 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Keratolytic winter erythema DIS2TO10 Strong Autosomal dominant [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
50 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Cathepsin B (CTSB). [2]
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Cathepsin B (CTSB). [3]
Tretinoin DM49DUI Approved Tretinoin increases the expression of Cathepsin B (CTSB). [4]
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Cathepsin B (CTSB). [5]
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Cathepsin B (CTSB). [6]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Cathepsin B (CTSB). [7]
Estradiol DMUNTE3 Approved Estradiol increases the expression of Cathepsin B (CTSB). [8]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Cathepsin B (CTSB). [9]
Quercetin DM3NC4M Approved Quercetin increases the expression of Cathepsin B (CTSB). [10]
Temozolomide DMKECZD Approved Temozolomide decreases the expression of Cathepsin B (CTSB). [11]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide decreases the expression of Cathepsin B (CTSB). [12]
Calcitriol DM8ZVJ7 Approved Calcitriol increases the expression of Cathepsin B (CTSB). [13]
Triclosan DMZUR4N Approved Triclosan increases the expression of Cathepsin B (CTSB). [14]
Carbamazepine DMZOLBI Approved Carbamazepine affects the expression of Cathepsin B (CTSB). [15]
Marinol DM70IK5 Approved Marinol increases the expression of Cathepsin B (CTSB). [16]
Zoledronate DMIXC7G Approved Zoledronate decreases the expression of Cathepsin B (CTSB). [17]
Selenium DM25CGV Approved Selenium increases the expression of Cathepsin B (CTSB). [18]
Cannabidiol DM0659E Approved Cannabidiol decreases the expression of Cathepsin B (CTSB). [20]
Diethylstilbestrol DMN3UXQ Approved Diethylstilbestrol increases the activity of Cathepsin B (CTSB). [22]
Azathioprine DMMZSXQ Approved Azathioprine increases the expression of Cathepsin B (CTSB). [23]
Dasatinib DMJV2EK Approved Dasatinib decreases the expression of Cathepsin B (CTSB). [24]
Indomethacin DMSC4A7 Approved Indomethacin decreases the activity of Cathepsin B (CTSB). [25]
Phenytoin DMNOKBV Approved Phenytoin increases the expression of Cathepsin B (CTSB). [26]
Beta-carotene DM0RXBT Approved Beta-carotene decreases the expression of Cathepsin B (CTSB). [27]
Imatinib DM7RJXL Approved Imatinib increases the expression of Cathepsin B (CTSB). [28]
Omeprazole DM471KJ Approved Omeprazole decreases the activity of Cathepsin B (CTSB). [29]
Amodiaquine DME4RA8 Approved Amodiaquine decreases the activity of Cathepsin B (CTSB). [30]
Propylthiouracil DM6D7N8 Approved Propylthiouracil decreases the expression of Cathepsin B (CTSB). [32]
Pyrimethamine DM5X7VY Approved Pyrimethamine increases the activity of Cathepsin B (CTSB). [33]
Urethane DM7NSI0 Phase 4 Urethane increases the expression of Cathepsin B (CTSB). [34]
SNDX-275 DMH7W9X Phase 3 SNDX-275 increases the expression of Cathepsin B (CTSB). [35]
Curcumin DMQPH29 Phase 3 Curcumin decreases the expression of Cathepsin B (CTSB). [36]
Seocalcitol DMKL9QO Phase 3 Seocalcitol increases the expression of Cathepsin B (CTSB). [37]
Chloroquine DMSI5CB Phase 3 Trial Chloroquine decreases the activity of Cathepsin B (CTSB). [38]
DNCB DMDTVYC Phase 2 DNCB increases the expression of Cathepsin B (CTSB). [40]
ANW-32821 DMMJOZD Phase 2 ANW-32821 decreases the activity of Cathepsin B (CTSB). [41]
GDC0941 DM1YAK6 Phase 2 GDC0941 increases the expression of Cathepsin B (CTSB). [42]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Cathepsin B (CTSB). [44]
AMEP DMFELMQ Phase 1 AMEP increases the expression of Cathepsin B (CTSB). [45]
PMID28870136-Compound-48 DMPIM9L Patented PMID28870136-Compound-48 increases the expression of Cathepsin B (CTSB). [46]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Cathepsin B (CTSB). [47]
Coumarin DM0N8ZM Investigative Coumarin increases the expression of Cathepsin B (CTSB). [48]
Coumestrol DM40TBU Investigative Coumestrol decreases the expression of Cathepsin B (CTSB). [49]
chloropicrin DMSGBQA Investigative chloropicrin decreases the expression of Cathepsin B (CTSB). [50]
Glyphosate DM0AFY7 Investigative Glyphosate increases the expression of Cathepsin B (CTSB). [45]
[3H]methyltrienolone DMTSGOW Investigative [3H]methyltrienolone decreases the expression of Cathepsin B (CTSB). [51]
QUERCITRIN DM1DH96 Investigative QUERCITRIN affects the expression of Cathepsin B (CTSB). [52]
acrolein DMAMCSR Investigative acrolein increases the expression of Cathepsin B (CTSB). [53]
U0126 DM31OGF Investigative U0126 decreases the expression of Cathepsin B (CTSB). [24]
Tetramethylbutylphenol DMW9CH2 Investigative Tetramethylbutylphenol increases the expression of Cathepsin B (CTSB). [8]
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⏷ Show the Full List of 50 Drug(s)
7 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT
Drug Name Drug ID Highest Status Interaction REF
Fluorouracil DMUM7HZ Approved Fluorouracil increases the cleavage of Cathepsin B (CTSB). [19]
Bortezomib DMNO38U Approved Bortezomib increases the localization of Cathepsin B (CTSB). [21]
Hydroxychloroquine DMSIVND Approved Hydroxychloroquine affects the localization of Cathepsin B (CTSB). [31]
Trifluridine DMG2YBD Approved Trifluridine increases the cleavage of Cathepsin B (CTSB). [19]
Amiodarone DMUTEX3 Phase 2/3 Trial Amiodarone affects the cleavage of Cathepsin B (CTSB). [39]
BEZ235 DMKBRDL Phase 2 BEZ235 affects the localization of Cathepsin B (CTSB). [43]
PATULIN DM0RV9C Investigative PATULIN increases the secretion of Cathepsin B (CTSB). [54]
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⏷ Show the Full List of 7 Drug(s)

References

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