General Information of This Drug (ID: DM2AQ5N)

Drug Name
Spironolactone   DM2AQ5N
Synonyms
Abbolactone; Acelat; Aldace; Aldactazide; Aldactide; Aldactone; Alderon; Aldopur; Almatol; Altex; Aquareduct; Deverol; Diatensec; Dira; Duraspiron; Espironolactona; Euteberol; Flumach; Frumikal; Jenaspiron; Lacalmin; Lacdene; Laractone; Melarcon; Nefurofan; NovoSpiroton; Osyrol; Practon; SNL; Sagisal; Sincomen; Spiractin; Spiresis; Spiretic; Spiridon; Spirobeta; Spiroctan; Spiroctanie; Spiroderm; Spirogamma; Spirolactone; Spirolakton; Spirolang; Spirolone; Spirone; Spironocompren; Spironolactonum; Spironolattone; Spironone; Spirospare; Sprioderm; Suracton; Uractone; Urusonin; Veroshpiron; Verospiron; Verospirone; Xenalon; Aldactone A; Alphapharm Brand of Spironolactone; Alpharma Brand of Spironolactone; Alter Brand of Spironolactone; Ashbourne Brand of Spironolactone; Azupharma Brand of Spironolactone; Betapharm Brand of Spironolactone; Cardel Brand of Spironolactone; Ct Arzneimittel Brand of Spironolactone; Dexo Brand of Spironolactone; Espironolactona Alter; Espironolactona Mundogen; Generosan Brand of Spironolactone; Hormosan Brand of Spironolactone; Jenapharm Brand of Spironolactone; Merck dura Brand of Spironolactone; Mundogen Brand of Spironolactone; Novo Spiroton; Novopharm Brand of Spironolactone; Pfizer Brand of Spironolactone; Pharmafrid Brand of Spironolactone; Roche Brand of Spironolactone; Searle Brand of Spironolactone; Spiro von ct; Spirono Isis; Spironolactone A; Spironolattone [DCIT]; Verospirone Opianin; Worwag Brand of Spironolactone; LT00772287; SC 9420; SC9420; Aldactazide (TN); Aldactone (TN); Berlactone (TN); Ct-Arzneimittel Brand of Spironolactone; Espironolactona [INN-Spanish]; Mayoly-Spindler Brand of Spironolactone; Novo-Spiroton; SC-9420; Spiractin (TN); Spiro-Tablinen; Spirono-Isis; Spironolactonum [INN-Latin]; Spirotone (TN); Supra-puren; Verospiron (TN); Von ct, spiro; Novo-Spiroton (TN); Spironolactone [BAN:INN:JAN]; Spironolactone [INN:BAN:JAN]; Spiro L.U.T.; Spironolactone (JP15/USP/INN); Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]; Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan); 4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone; 7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Congestive heart failure BD10 Approved [2]
Edema MG29 Approved [1]
Hyperaldosteronism 5A72 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Therapeutic Class
Diuretics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

60 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Spironolactone DCH80QT Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Bortezomib + Spironolactone DCR2TV8 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Spironolactone DCFC2AI Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
BRL-15572 + Spironolactone DCJDL5K BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Busulfan + Spironolactone DCVFDIL Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cerivastatin + Spironolactone DCX4XSY Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Citalopram + Spironolactone DCSA8ES Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diethylcarbamazine + Spironolactone DCOALDN Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Doxorubicin + Spironolactone DCB2AJW Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Epinephrine + Spironolactone DC0BPMF Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fomepizole + Spironolactone DC2M41U Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
GSK2194069 + Spironolactone DCH6C4M GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hyodeoxycholic acid + Spironolactone DCIGP8X Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Ibutilide + Spironolactone DCSEEW0 Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Idarubicin + Spironolactone DCIEEOX Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Imipramine + Spironolactone DCXIXBF Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Spironolactone DCVE0JL Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Levamisole + Spironolactone DCJ5TGY Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Maprotiline + Spironolactone DC8HXAK Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Metyrosine + Spironolactone DCURT5Q Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mycophenolic acid + Spironolactone DCPKQJ7 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Naltrexone + Spironolactone DCFSKS4 Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Niclosamide + Spironolactone DCWLNXH Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Olanzapine + Spironolactone DC7RXBH Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Olmesartan medoxomil + Spironolactone DCTMHXN Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pazopanib + Spironolactone DCDV4R2 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Rifampin + Spironolactone DCAWKL4 Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sertraline + Spironolactone DCVHPX1 Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Aprepitant DCDOO5M Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Meclofenamic acid DC36WTU Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Dantrolene DCXTWHT Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Kanamycin DCO96RQ Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Tindamax DCZD4IL Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + PMID28460551-Compound-2 DCJDODY PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Methotrexate DC2ZCCB Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Vinblastine DCLZZPZ Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Triapine DCH6DRB Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Emetine DCH2DZY Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Cinacalcet DCK1C8F Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Carglumic acid DCKP3TD Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Docetaxel DCN9JIH Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + LY03004 DCWD5OG LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Ginsenoside Rb1 DCVNG29 Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Tolvaptan DCQDKFK Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Diazoxide DC6UWS9 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Pargyline DCWBAEF Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Imatinib DC40C3U Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Cefmenoxime DCTTHWH Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Trimethobenzamide DC099MB Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Ethambutol DCM3SQW Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Asenapine DCZLURT Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Endoxifen DC5L8PM Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Mefloquine DCCFANV Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Nitisinone DCQI4WI Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Auranofin DC4MRVS Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Vorinostat DC3GGR7 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Spironolactone + Aciclovir DCL6B98 Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tiagabine + Spironolactone DCIR0KC Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Topotecan + Spironolactone DCC40FQ Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tropisetron + Spironolactone DCEYTV7 Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
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⏷ Show the Full List of 60 DrugCom(s)
13 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Aliskiren + Spironolactone DC7F3G3 Aliskiren Metabolic Diseases [6]
Amlodipine + Spironolactone DC3AZZ4 Amlodipine Hypertension [7]
Furosemide + Spironolactone DCLDL9I Furosemide AML [8]
Spironolactone + Losartan DCFC7WO Losartan Chronic Renal Disease [9]
Spironolactone + Spironolactone DCJEHWA Spironolactone Metabolic Diseases [6]
Spironolactone + Estradiol DC9917Y Estradiol Transgender Health [10]
Venetoclax + Spironolactone DC5CFAI Venetoclax Acute Myeloid Leukemia [11]
Chlorthalidone + Spironolactone DC0X15D Chlorthalidone Renal Insufficiency [12]
Pemoline + Spironolactone DCAX1MH Pemoline Polycystic Ovary Syndrome (PCOS) [13]
Spironolactone + Colchicine DC6JEVX Colchicine ST Elevation Myocardial Infarction [14]
Spironolactone + Dihydralazine DC6OONO Dihydralazine Aortic Stenosis, Severe [15]
Minoxidil + Spironolactone DCHY1PJ Minoxidil Female Androgenetic Alopecia [16]
Spironolactone + Losartan DCJ9HE1 Losartan End Stage Renal Disease [17]
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⏷ Show the Full List of 13 DrugCom(s)

References

1 Spironolactone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2875).
3 Spironolactone in Covid-19 Induced ARDS
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6 ClinicalTrials.gov (NCT01103245) Aldosterone and the Metabolic Syndrome
7 ClinicalTrials.gov (NCT03626506) Spironolactone Versus Indapamide in Obese and Hypertensive Patients
8 ClinicalTrials.gov (NCT02575963) Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients
9 ClinicalTrials.gov (NCT02190318) Residual Renal Function Preservation in Peritoneal Dialysis Patients
10 ClinicalTrials.gov (NCT04283656) Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women
11 ClinicalTrials.gov (NCT03867682) Venetoclax and Lintuzumab-Ac225 in AML Patients
12 ClinicalTrials.gov (NCT05222191) Spironolactone in CKD Enabled by Chlorthalidone: PILOT
13 ClinicalTrials.gov (NCT05394142) A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)
14 ClinicalTrials.gov (NCT03048825) Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry
15 ClinicalTrials.gov (NCT05230901) Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden
16 ClinicalTrials.gov (NCT02483195) The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia
17 ClinicalTrials.gov (NCT03953950) Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis Patients